Insulinoma differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Overview

Insulinoma must be differentiated from other diseases that cause features of hypoglycemia like palpitations, profuse sweating, dizziness, such as [differential dx1], [differential dx2], and [differential dx3].

OR

Insulinoma must be differentiated from the exogenous use of insulin, drugs causing hypoglycemia like sulfonylureas.

Differentiating insulinoma from other Diseases

  • [Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
  • [Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].
  • As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].

Preferred Table for differentials for Hypoglycemia

Diseases Laboratory Findings differentiating among causes of Hypoglycemia
S.Glucose
(mg/dL)/(mmol/L)
C Peptide (pmol/L) S.Insulin (μU/mL)/(pmol/L) S.Proinsulin
(pmol/L)
S. Beta hydroxybutyrate Glucose increase after glucagon(mg/dL)
Exogenous Insulin <50/2.5 <200 ↑↑
Insulinoma ' -
Autoimmune Insulin
Differential Diagnosis 4
Differential Diagnosis 5

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