Hereditary nonpolyposis colorectal cancer epidemiology and demographics: Difference between revisions
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In the United States, about 160,000 new cases of [[colorectal cancer]] are diagnosed each year. Hereditary nonpolyposis colorectal cancer is responsible for approximately 2-7% of all diagnosed cases of [[colorectal cancer]]. The average age of diagnosis of cancer in patients with this syndrome is 44 years old, as compared to 64 years old in people without the syndrome.<ref name="wiki"> Hereditary nonpolyposis colorectal cancer. Wikipedia. https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer Accessed on December 01, 2015 </ref> | In the United States, about 160,000 new cases of [[colorectal cancer]] are diagnosed each year. Hereditary nonpolyposis colorectal cancer is responsible for approximately 2-7% of all diagnosed cases of [[colorectal cancer]]. The average age of diagnosis of cancer in patients with this syndrome is 44 years old, as compared to 64 years old in people without the syndrome.<ref name="wiki"> Hereditary nonpolyposis colorectal cancer. Wikipedia. https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer Accessed on December 01, 2015 </ref> | ||
===Prevalence=== | ===Prevalence=== | ||
*The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2-7% of all diagnosed cases of colorectal cancer.<ref name="pmid9593786">{{cite journal |vauthors=Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A |title=Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease |journal=N. Engl. J. Med. |volume=338 |issue=21 |pages=1481–7 |year=1998 |pmid=9593786 |doi=10.1056/NEJM199805213382101 |url=}}</ref> | |||
===Age=== | ===Age=== | ||
*HNPCC commonly affects young adult population. | |||
*The average age of diagnosis is often less than 45 years old.<ref name="pmid9593786">{{cite journal |vauthors=Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A |title=Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease |journal=N. Engl. J. Med. |volume=338 |issue=21 |pages=1481–7 |year=1998 |pmid=9593786 |doi=10.1056/NEJM199805213382101 |url=}}</ref> | |||
===Gender=== | ===Gender=== | ||
* HNPCC affects men and women equally. | |||
* In some particular genetic mutations such as MLH1 males have significantly higher risk than females at all ages.<ref name="pmid9593786">{{cite journal |vauthors=Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A |title=Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease |journal=N. Engl. J. Med. |volume=338 |issue=21 |pages=1481–7 |year=1998 |pmid=9593786 |doi=10.1056/NEJM199805213382101 |url=}}</ref> | |||
===Race=== | ===Race=== | ||
*HNPCC usually affects individuals of the white race more commonly. | |||
*Ethnically-diverse individuals are less likely to develop MMR mutations related with hereditary nonpolyposis colorectal cancer.<ref name="wiki"> Hereditary nonpolyposis colorectal cancer. Wikipedia. https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer Accessed on December 01, 2015 </ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2-7% of all diagnosed cases of colorectal cancer.[1] HNPCC commonly affects young adult population. The median age of diagnosis is between 40 to 45 years.[1] Hereditary nonpolyposis colorectal cancer affects men and women equally.[2] HNPCC usually affects individuals of the white race more commonly. Ethnically-diverse individuals are less likely to develop MMR mutations related with hereditary nonpolyposis colorectal cancer.[3]
Epidemiology and Demographics
In the United States, about 160,000 new cases of colorectal cancer are diagnosed each year. Hereditary nonpolyposis colorectal cancer is responsible for approximately 2-7% of all diagnosed cases of colorectal cancer. The average age of diagnosis of cancer in patients with this syndrome is 44 years old, as compared to 64 years old in people without the syndrome.[2]
Prevalence
- The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2-7% of all diagnosed cases of colorectal cancer.[1]
Age
- HNPCC commonly affects young adult population.
- The average age of diagnosis is often less than 45 years old.[1]
Gender
- HNPCC affects men and women equally.
- In some particular genetic mutations such as MLH1 males have significantly higher risk than females at all ages.[1]
Race
- HNPCC usually affects individuals of the white race more commonly.
- Ethnically-diverse individuals are less likely to develop MMR mutations related with hereditary nonpolyposis colorectal cancer.[2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A (1998). "Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease". N. Engl. J. Med. 338 (21): 1481–7. doi:10.1056/NEJM199805213382101. PMID 9593786.
- ↑ 2.0 2.1 2.2 Hereditary nonpolyposis colorectal cancer. Wikipedia. https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer Accessed on December 01, 2015
- ↑ Monteiro santos EM, Valentin MD, Carneiro F, et al. Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries. BMC Cancer. 2012;12:64.