Hepatitis A causes: Difference between revisions
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===Genome=== | ===Genome=== | ||
The [[HAV]] [[genome]] is | The [[HAV]] [[genome]] is encoded in 7474 [[nucleotides]], which are divided into three regions: | ||
* 5' untranslated region | * 5' untranslated region, with 742 [[nucleotides]] | ||
* | * Single reading frame encoding a 2227 [[amino acid]] [[polypeptide]], with 6681 [[nucleotides]] | ||
* 3' noncoding region | * 3' noncoding region, with 63 [[nucleotides]] | ||
The polypeptide encoded by the open reading frame is cotranslationally processed by a viral protease, resulting in four structural and seven nonstructural proteins (figure 1). | The polypeptide encoded by the open reading frame is cotranslationally processed by a viral protease, resulting in four structural and seven nonstructural proteins (figure 1). |
Revision as of 19:08, 28 July 2014
Hepatitis A |
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Treatment |
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Hepatitis A causes On the Web |
American Roentgen Ray Society Images of Hepatitis A causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Taxonomy
Viruses; ssRNA] viruses; ssRNA virus; positive-strand viruses; Picornavirales; Picornaviridae; Hepatovirus
Biology
Hepatitis A virus (HAV) is a non-enveloped, icosahedral, ssRNA virus with a single serovar. It is 27 nm in length
Genome
The HAV genome is encoded in 7474 nucleotides, which are divided into three regions:
- 5' untranslated region, with 742 nucleotides
- Single reading frame encoding a 2227 amino acid polypeptide, with 6681 nucleotides
- 3' noncoding region, with 63 nucleotides
The polypeptide encoded by the open reading frame is cotranslationally processed by a viral protease, resulting in four structural and seven nonstructural proteins (figure 1).
Four distinct genotypes of HAV have been identified in humans, although they do not appear to have important biological differences [3]. All four genotypes belong to a single serotype.
Tropism
Natural Reservoir
References
- ↑ "http://phil.cdc.gov/phil/details.asp". External link in
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