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[[File:MSUcrystals.jpg|thumb|Monosodium urate crystals showing negative birefringence<ref name="url00214108 | PEIR Digital Library">{{cite web |url=http://peir.path.uab.edu/library/picture.php?/22177/search/7357 |title=00214108 &#124; PEIR Digital Library |format= |work= |accessdate=}}</ref>]]
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== Overview ==
== Overview ==


== Diagnostic Study of Choice ==
== Diagnostic Study of Choice ==
* The diagnostic standard is synovial fluid or tophus aspiration with identification of monosodium urate crystals.
* The diagnostic standard is synovial fluid or tophus aspiration with identification of monosodium urate crystals.
*[[File:MSUcrystals.jpg|thumb|Monosodium urate crystals showing negative birefringence<ref name="url00214108 | PEIR Digital Library">{{cite web |url=http://peir.path.uab.edu/library/picture.php?/22177/search/7357 |title=00214108 &#124; PEIR Digital Library |format= |work= |accessdate=}}</ref>]]Synovial fluid is aspirated from the inflamed joint by careful arthrocentesis.
* Synovial fluid is aspirated from the inflamed joint by careful arthrocentesis.
* The sample is then analyzed for characteristic negatively birefringent monosodium urate crystals which appear needle-like structures of 1–20 μm in length under polarized microscopy. This is central to confirm the diagnosis of gout. 22303530 18299687   
* The sample is then analyzed for characteristic negatively birefringent monosodium urate crystals which appear needle-like structures of 1–20 μm in length under polarized microscopy. This is central to confirm the diagnosis of gout. 22303530 18299687   
* It also helps in differentiating gout from acute calcium pyrophosphate crystal arthritis (pseudogout) and septic arthritis.16707533
* It also helps in differentiating gout from acute calcium pyrophosphate crystal arthritis (pseudogout) and septic arthritis.16707533

Revision as of 12:05, 27 April 2018

Monosodium urate crystals showing negative birefringence[1]


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Diagnostic Study of Choice

  • The diagnostic standard is synovial fluid or tophus aspiration with identification of monosodium urate crystals.
  • Synovial fluid is aspirated from the inflamed joint by careful arthrocentesis.
  • The sample is then analyzed for characteristic negatively birefringent monosodium urate crystals which appear needle-like structures of 1–20 μm in length under polarized microscopy. This is central to confirm the diagnosis of gout. 22303530 18299687
  • It also helps in differentiating gout from acute calcium pyrophosphate crystal arthritis (pseudogout) and septic arthritis.16707533


References

  1. "00214108 | PEIR Digital Library".

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