Goodpasture syndrome risk factors: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
 
(22 intermediate revisions by 5 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
Please help WikiDoc by adding content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.
{{Goodpastures syndrome}}
{{CMG}}{{APM}}{{AE}}{{KW}}


{{Goodpastures syndrome}}
==Overview==
Common risk factors in the development of Goodpasture syndrome may be occupational, environmental, [[genetic]], and [[viral]]. However, we don't known what causes the antibodies to form.
 
==Risk Factors==
Common risk factors in the development of Goodpasture syndrome may be occupational, environmental, [[genetic]], and [[viral]]. <ref name="pmid24456936">{{cite journal| author=Hellmark T, Segelmark M| title=Diagnosis and classification of Goodpasture's disease (anti-GBM). | journal=J Autoimmun | year= 2014 | volume= 48-49 | issue=  | pages= 108-12 | pmid=24456936 | doi=10.1016/j.jaut.2014.01.024 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24456936  }} </ref><ref name="pmid1536151">{{cite journal| author=Bombassei GJ, Kaplan AA| title=The association between hydrocarbon exposure and anti-glomerular basement membrane antibody-mediated disease (Goodpasture's syndrome). | journal=Am J Ind Med | year= 1992 | volume= 21 | issue= 2 | pages= 141-53 | pmid=1536151 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1536151  }} </ref>
*Recent studies suggest that infections such as [[viral]] or [[bacterial]] may play a role through [[molecular mimicry]] and increase the risk of developing Goodpasture syndrome.
*Other factors that may increase the risk of Goodpasture syndrome and early initiation of disease include [[behavioral]] and social factors.
**An example of environmental, [[genetic]], behavioral and social factors include [[smoking]], using [[cocaine]], being exposed to solvents such as [[formaldehyde]] and [[hydrocarbons]].
**Genetically, the presence of allele HLA DRB1-1501 is strongly correlated to the disease.<ref name="pmid19741587">{{cite journal| author=Zhao J, Cui Z, Yang R, Jia XY, Zhang Y, Zhao MH| title=Anti-glomerular basement membrane autoantibodies against different target antigens are associated with disease severity. | journal=Kidney Int | year= 2009 | volume= 76 | issue= 10 | pages= 1108-15 | pmid=19741587 | doi=10.1038/ki.2009.348 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19741587  }} </ref>
**The allele HLA DRB1-1501 is present in over 80% of patients would Goodpasture syndrome.<ref name="pmid27049372">{{cite journal| author=Couser WG| title=Pathogenesis and treatment of glomerulonephritis-an update. | journal=J Bras Nefrol | year= 2016 | volume= 38 | issue= 1 | pages= 107-22 | pmid=27049372 | doi=10.5935/0101-2800.20160016 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27049372  }} </ref>
**It is also suggestive that the disease may be initiated following a [[viral]] or [[bacterial]] infection, however, there is no specific cause of why this occurs. Possible [[antigens]] such as that found in the [[influenza virus]] may play a role due to cross-reactivity in the [[basement membrane]].<ref name="pmid4571918">{{cite journal| author=Wilson CB, Dixon FJ| title=Anti-glomerular basement membrane antibody-induced glomerulonephritis. | journal=Kidney Int | year= 1973 | volume= 3 | issue= 2 | pages= 74-89 | pmid=4571918 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4571918  }}</ref>
*In addition, any of the following conditions may also increase [[antibody]] access to the [[alveolar]] and [[Glomerular basement membrane|glomerular basement membranes]].
**[[Upper respiratory infections]]
**[[Septicemia]]
**Volatile [[hydrocarbons]]
**Increased capillary [[hydrostatic pressure]]
**[[Tobacco]] [[smoking]]
**High concentrations of [[FiO2]] (oxygen)


==References==
==References==
Line 14: Line 32:
[[Category:Pulmonology]]
[[Category:Pulmonology]]
[[Category:Needs content]]
[[Category:Needs content]]
[[Category:Disease]]

Latest revision as of 13:26, 23 July 2018

Goodpasture syndrome Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Goodpasture syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Goodpasture syndrome risk factors On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Goodpasture syndrome risk factors

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Goodpasture syndrome risk factors

CDC on Goodpasture syndrome risk factors

Goodpasture syndrome risk factors in the news

Blogs on Goodpasture syndrome risk factors

Directions to Hospitals Treating Goodpasture syndrome

Risk calculators and risk factors for Goodpasture syndrome risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

Overview

Common risk factors in the development of Goodpasture syndrome may be occupational, environmental, genetic, and viral. However, we don't known what causes the antibodies to form.

Risk Factors

Common risk factors in the development of Goodpasture syndrome may be occupational, environmental, genetic, and viral. [1][2]

References

  1. Hellmark T, Segelmark M (2014). "Diagnosis and classification of Goodpasture's disease (anti-GBM)". J Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.
  2. Bombassei GJ, Kaplan AA (1992). "The association between hydrocarbon exposure and anti-glomerular basement membrane antibody-mediated disease (Goodpasture's syndrome)". Am J Ind Med. 21 (2): 141–53. PMID 1536151.
  3. Zhao J, Cui Z, Yang R, Jia XY, Zhang Y, Zhao MH (2009). "Anti-glomerular basement membrane autoantibodies against different target antigens are associated with disease severity". Kidney Int. 76 (10): 1108–15. doi:10.1038/ki.2009.348. PMID 19741587.
  4. Couser WG (2016). "Pathogenesis and treatment of glomerulonephritis-an update". J Bras Nefrol. 38 (1): 107–22. doi:10.5935/0101-2800.20160016. PMID 27049372.
  5. Wilson CB, Dixon FJ (1973). "Anti-glomerular basement membrane antibody-induced glomerulonephritis". Kidney Int. 3 (2): 74–89. PMID 4571918.

Template:WH Template:WS