Glucagonoma risk factors: Difference between revisions

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__NOTOC__
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{{Glucagonoma}}
{{Glucagonoma}}
{{CMG}}; {{AE}} {{PSD}} {{MAD}}
{{CMG}}; {{AE}} {{PSD}}, {{MAD}}
==Overview==
==Overview==
The most common risk factor in the development of glucagonoma is a positive family history of [[multiple endocrine neoplasia type 1|multiple endocrine neoplasia type1]] which is characterized by the presence of [[Pituitary adenoma|pituitary adenomas]], [[Islet cell tumor|islet cell tumors]] of the [[pancreas]], and [[hyperparathyroidism]].
The most common risk factor in the development of glucagonoma is a positive family history of [[multiple endocrine neoplasia type 1|multiple endocrine neoplasia type1]] which is characterized by the presence of [[Pituitary adenoma|pituitary adenomas]], [[Islet cell tumor|islet cell tumors]] of the [[pancreas]], and [[hyperparathyroidism]].
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* The most common risk factor in the development of glucagonoma is a positive family history of [[multiple endocrine neoplasia type 1]].<ref name="pmid22970401">{{cite journal| author=Afsharfard A, Atqiaee K, Lotfollahzadeh S, Alborzi M, Derakhshanfar A| title=Necrolytic migratory erythema as the first manifestation of glucagonoma. | journal=Case Rep Surg | year= 2012 | volume= 2012 | issue=  | pages= 974210 | pmid=22970401 | doi=10.1155/2012/974210 | pmc=PMC3434377 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22970401  }} </ref><ref name="causes">Glucagonoma. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000326.htm</ref>
* The most common risk factor in the development of glucagonoma is a positive family history of [[multiple endocrine neoplasia type 1]].<ref name="pmid22970401">{{cite journal| author=Afsharfard A, Atqiaee K, Lotfollahzadeh S, Alborzi M, Derakhshanfar A| title=Necrolytic migratory erythema as the first manifestation of glucagonoma. | journal=Case Rep Surg | year= 2012 | volume= 2012 | issue=  | pages= 974210 | pmid=22970401 | doi=10.1155/2012/974210 | pmc=PMC3434377 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22970401  }} </ref><ref name="causes">Glucagonoma. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000326.htm</ref>
** It is an [[Autosomal dominant inheritance|autosomal dominant]] syndrome that is usually caused by mutations in the [[MEN1 syndrome|''MEN1'' gene]].
** It is an [[Autosomal dominant inheritance|autosomal dominant]] syndrome that is usually caused by mutations in the [[MEN1 syndrome|''MEN1'' gene]].
** It is characterized by the development of the following tumors:<sup>[[Multiple endocrine neoplasia type 1 pathophysiology#cite note-wikipedia-1|[1]]]</sup>
** It is characterized by the development of the following tumors:<sup>[[Multiple endocrine neoplasia type 1 pathophysiology#cite note-wikipedia-1|[1]]]</sup>
*** [[Pituitary adenoma|Pituitary adenomas]]
*** [[Pituitary adenoma|Pituitary adenomas]]
*** [[Islet cell tumor|Islet cell tumors]] of the [[pancreas]] (commonly [[gastrinoma]] and glucagonoma)
*** [[Islet cell tumor|Islet cell tumors]] of the [[pancreas]] (commonly [[gastrinoma]] and glucagonoma)
*** [[Parathyroid]] [[hyperplasia]] with resulting [[hyperparathyroidism]]
*** [[Parathyroid]] [[hyperplasia]] with resulting [[hyperparathyroidism]]
* The [[gene]] [[locus]] causing [[multiple endocrine neoplasia type 1]] has been localized to [[chromosome]] 11q13 by studies of [[loss of heterozygosity]] on [[multiple endocrine neoplasia type 1]]-associated [[Tumor|tumors]] and by linkage analysis in [[multiple endocrine neoplasia type 1]] families.<ref name="pmid2894610">{{cite journal| author=Larsson C, Skogseid B, Oberg K, Nakamura Y, Nordenskjöld M| title=Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. | journal=Nature | year= 1988 | volume= 332 | issue= 6159 | pages= 85-7 | pmid=2894610 | doi=10.1038/332085a0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2894610  }}</ref>
* ''[[MEN1]]'' spans about 10 Kb and consists of ten exons encoding a 610 [[amino acid]] nuclear protein, named menin.<ref name="pmid1968641">{{cite journal| author=Byström C, Larsson C, Blomberg C, Sandelin K, Falkmer U, Skogseid B et al.| title=Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors. | journal=Proc Natl Acad Sci U S A | year= 1990 | volume= 87 | issue= 5 | pages= 1968-72 | pmid=1968641 | doi= | pmc=53606 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1968641  }}</ref>
* ''[[MEN1]]'' [[gene]] is a [[tumor suppressor gene]] and causes type 1 multiple endocrine neoplasia by the [[two hits]] model for [[tumor]] development.<ref name="pmid2568586">{{cite journal| author=Friedman E, Sakaguchi K, Bale AE, Falchetti A, Streeten E, Zimering MB et al.| title=Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1. | journal=N Engl J Med | year= 1989 | volume= 321 | issue= 4 | pages= 213-8 | pmid=2568586 | doi=10.1056/NEJM198907273210402 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2568586  }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist|2}}
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{{WS}}
[[Category:Medicine]]
[[Category:Endocrinology]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Gastroenterology]]
[[Category:Surgery]]

Latest revision as of 01:49, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2], Mohammed Abdelwahed M.D[3]

Overview

The most common risk factor in the development of glucagonoma is a positive family history of multiple endocrine neoplasia type1 which is characterized by the presence of pituitary adenomas, islet cell tumors of the pancreas, and hyperparathyroidism.

Risk Factors

References

  1. Afsharfard A, Atqiaee K, Lotfollahzadeh S, Alborzi M, Derakhshanfar A (2012). "Necrolytic migratory erythema as the first manifestation of glucagonoma". Case Rep Surg. 2012: 974210. doi:10.1155/2012/974210. PMC 3434377. PMID 22970401.
  2. Glucagonoma. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000326.htm

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