Glanzmann's thrombasthenia risk factors: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Glanzmann's thrombasthenia}} | {{Glanzmann's thrombasthenia}} | ||
* {{CMG}} | |||
{{ | ==Overview== | ||
The risk of Glanzmann's thrombathenia in children coming from consanguineous marriage is much higher. <ref name="pmidDOI: 10.1002/ajh.20159">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=DOI: 10.1002/ajh.20159 | doi= | pmc=5922622 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }}</ref> | |||
Autoantibodies are another important cause of acquired GT . | |||
==Risk Factors== | ==Risk Factors== | ||
The autoantibodies production can be result of following conditions: | |||
* Hematologic disorders and malignancies, such as : | |||
# acute lymphoblastic leukemia, | |||
# non-Hodgkin’s lymphoma | |||
# multiple myeloma | |||
# hairy cell leukemia | |||
# myelodysplastic syndrome | |||
# immune thrombocytopenic purpura (ITP) | |||
* Autoimmune diseases, such as lupus (Blickstein et al) | |||
* Drugs : anti-thrombotic drugs use , like abciximab, eptifibatide, and tirofiban which all antagonize αIIbβ3 | |||
* platelet transfusions.[[Glanzmann's thrombasthenia classification#cite note-pmid1990.3B75:1383.E2.80.93952-6|[6]]] | |||
==References== | ==References== |
Revision as of 15:40, 6 July 2018
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- Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The risk of Glanzmann's thrombathenia in children coming from consanguineous marriage is much higher. [1]
Autoantibodies are another important cause of acquired GT .
Risk Factors
The autoantibodies production can be result of following conditions:
- Hematologic disorders and malignancies, such as :
- acute lymphoblastic leukemia,
- non-Hodgkin’s lymphoma
- multiple myeloma
- hairy cell leukemia
- myelodysplastic syndrome
- immune thrombocytopenic purpura (ITP)
- Autoimmune diseases, such as lupus (Blickstein et al)
- Drugs : anti-thrombotic drugs use , like abciximab, eptifibatide, and tirofiban which all antagonize αIIbβ3
- platelet transfusions.[6]
References
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMC 5922622. PMID 10.1002/ajh.20159 DOI: 10.1002/ajh.20159 Check
|pmid=
value (help).