Gallstone disease history and symptoms: Difference between revisions

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==Overview==
==Overview==
 
Gallstone disease can manifest in a number of ways. Most patients have a history of [[obesity]], [[Pregnancy|multiple pregnancies]], use of [[Oral contraceptive|oral contraceptive pills]], [[Ageing|age]] of 40 years old and over, female and of Caucasian or Native American race. Some patients may be in a physical state that favors the development of gallstones but don't develop them, some patients may have gallstones, but are [[asymptomatic]]. These gallstones are detected incidentally. Some may have gallstones and experience biliary colic, [[Nausea and vomiting|nausea]], [[Nausea and vomiting|vomiting]] and [[diarrhea]], whilst others will have complications due to gallstones, such as [[acute cholecystitis]] and [[acute pancreatitis]].  
The diagnosis of uncomplicated gallstone disease is made in a patient who may be asymptomatic or experiencing biliary colic with a normal physical examination and normal laboratory tests including [[complete blood count]], [[aminotransferases]], [[bilirubin]], [[alkaline phosphatase]], [[amylase]], and [[lipase]]. The next step should be to image these patients to determine if there are gallbladder stones or sludge. Typically, the evaluation begins with a transabdominal [[ultrasound]] since it is the most sensitive modality for detecting gallbladder stones. If the transabdominal ultrasound is negative in a patient with biliary colic, additional studies that may help with the diagnosis include endoscopic ultrasound (EUS) and bile [[microscopy]]. Most patients are females over the age of 40 whom have had multiple children and tend to have a [[Body mass index|BMI]] over 25. <ref name="pmid2368790">{{cite journal |vauthors=Diehl AK, Sugarek NJ, Todd KH |title=Clinical evaluation for gallstone disease: usefulness of symptoms and signs in diagnosis |journal=Am. J. Med. |volume=89 |issue=1 |pages=29–33 |year=1990 |pmid=2368790 |doi= |url=}}</ref>
==History and Symptoms ==
 
==History and Symptoms==
* The majority of patients with gallstone disease are [[asymptomatic]].<ref>{{cite web |url=http://www.emedicine.com/med/topic836.htm#section~clinical |title=Cholelithiasis |accessdate=2007-08-25 |work=emedicine from WebMD}}</ref>
* Patients start developing symptoms once the stones reach a certain size (>8mm).<ref>{{cite web |url=http://www.nlm.nih.gov/medlineplus/ency/article/000273.htm#Symptoms%20Medline%20Plus |title=Gallstones |accessdate=2007-08-25 |work=Medline Plus}}</ref>
** A gallstone "attack", also known as '''biliary colic''' is described as intense pain in the upper abdominal region that steadily increases for approximately thirty minutes to several hours with pain in the back, ordinarily between the shoulder blades, or pain under the right shoulder (Collins' sign). This occurs when the disease symptomatizes. Eventually, the pain subsides. A positive history for [[obesity]], [[Parity (medicine)|multiparity]] and age over 40 is suggestive of gallstones.<ref name="pmid2368790">{{cite journal |vauthors=Diehl AK, Sugarek NJ, Todd KH |title=Clinical evaluation for gallstone disease: usefulness of symptoms and signs in diagnosis |journal=Am. J. Med. |volume=89 |issue=1 |pages=29–33 |year=1990 |pmid=2368790 |doi= |url=}}</ref>


===History===
===History===
Patients with gallstones may have a positive history of:
* Obtaining history is an important aspect of making a diagnosis of gallstone disease.<ref name="pmid2368790">{{cite journal |vauthors=Diehl AK, Sugarek NJ, Todd KH |title=Clinical evaluation for gallstone disease: usefulness of symptoms and signs in diagnosis |journal=Am. J. Med. |volume=89 |issue=1 |pages=29–33 |year=1990 |pmid=2368790 |doi= |url=}}</ref><ref name="pmid11711412">{{cite journal |vauthors=Johnson CD |title=ABC of the upper gastrointestinal tract. Upper abdominal pain: Gall bladder |journal=BMJ |volume=323 |issue=7322 |pages=1170–3 |year=2001 |pmid=11711412 |pmc=1121646 |doi= |url=}}</ref>
*[[Obesity]]
*Eating fatty foods
* The areas of focus should be on onset, duration, and progression of symptoms such as:
*[[Parity (medicine)|Multiparity]]
**[[Obesity]]
*[[Aging|Age over 40]]
**Eating fatty foods
*Female
**[[Parity (medicine)|Multiparity]]
*Caucasian or Native American <ref name="pmid11711412">{{cite journal |vauthors=Johnson CD |title=ABC of the upper gastrointestinal tract. Upper abdominal pain: Gall bladder |journal=BMJ |volume=323 |issue=7322 |pages=1170–3 |year=2001 |pmid=11711412 |pmc=1121646 |doi= |url=}}</ref>
**[[Aging|Age over 40]]
 
**Female
Gallstone disease can be categorized as having 4 different stages,
**[[Oral contraceptive|Oral contraceptive pill]]
 
**Caucasian or Native American race
1.The lithogenic state, in which conditions favor gallstone formation
===Common Symptoms===
 
*The majority of patients with gallstone disease are [[asymptomatic]].<ref name="pmid2368790">{{cite journal |vauthors=Diehl AK, Sugarek NJ, Todd KH |title=Clinical evaluation for gallstone disease: usefulness of symptoms and signs in diagnosis |journal=Am. J. Med. |volume=89 |issue=1 |pages=29–33 |year=1990 |pmid=2368790 |doi= |url=}}</ref><ref>{{cite web |url=http://www.nlm.nih.gov/medlineplus/ency/article/000273.htm#Symptoms%20Medline%20Plus |title=Gallstones |accessdate=2007-08-25 |work=Medline Plus}}</ref><ref name="pmid13848582">{{cite journal |vauthors=LUND J |title=Surgical indications in cholelithiasis: prophylactic choleithiasis: prophylactic cholecystectomy elucidated on the basis of long-term follow up on 526 nonoperated cases |journal=Ann. Surg. |volume=151 |issue= |pages=153–62 |year=1960 |pmid=13848582 |pmc=1613279 |doi= |url=}}</ref>  
2.Asymptomatic gallstones
*Patients start developing symptoms once the stones reach a certain size (>8mm):
 
**[[Abdominal pain|Right upper quadrant pain]] or '''biliary colic''': intense [[pain]] in the upper [[abdominal]] region
3.Symptomatic gallstones, characterized by episodes of biliary colic (symptoms are listed below)
*** The [[pain]] steadily increases for approximately thirty minutes to several hours.
 
*** [[Pain]] is sometimes referred to the middle of the back or the tip of the right shoulder.
4.Complicated [[Gallstone disease|cholelithiasis]]
**[[Nausea and vomiting|Nausea]]
 
**[[Nausea and vomiting|Vomiting]]
===Common Symptoms of Biliary Colic===
**[[Diarrhea]]
Common symptoms of gallstones include:
*[[Abdominal pain|Right upper quadrant pain]]
*[[Nausea and vomiting|Nausea]]
*[[Nausea and vomiting|Vomiting]]
*[[Diarrhea]]<ref name="pmid13848582">{{cite journal |vauthors=LUND J |title=Surgical indications in cholelithiasis: prophylactic choleithiasis: prophylactic cholecystectomy elucidated on the basis of long-term follow up on 526 nonoperated cases |journal=Ann. Surg. |volume=151 |issue= |pages=153–62 |year=1960 |pmid=13848582 |pmc=1613279 |doi= |url=}}</ref>


===Less Common Symptoms of Biliary Colic===
===Less Common Symptoms===
Less common symptoms of gallstones include  
Less common symptoms include:<ref name="pmid12802649">{{cite journal |vauthors=Berger MY, Olde Hartman TC, Bohnen AM |title=Abdominal symptoms: do they disappear after cholecystectomy? |journal=Surg Endosc |volume=17 |issue=11 |pages=1723–8 |year=2003 |pmid=12802649 |doi=10.1007/s00464-002-9154-6 |url=}}</ref>
*[[Chest pain]]
*[[Chest pain]]
*Fullness after eating/early [[satiety]]
*Fullness after eating or early [[satiety]]
*[[Burping|Belching]]<ref name="pmid12802649">{{cite journal |vauthors=Berger MY, Olde Hartman TC, Bohnen AM |title=Abdominal symptoms: do they disappear after cholecystectomy? |journal=Surg Endosc |volume=17 |issue=11 |pages=1723–8 |year=2003 |pmid=12802649 |doi=10.1007/s00464-002-9154-6 |url=}}</ref>
*Frequent [[Burping|belching]]


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
[[Category:Hepatology]]
[[Category:Hepatology]]
[[Category:Surgery]]
[[Category:Surgery]]
[[Category:Primary care]]
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Latest revision as of 21:48, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]

Overview

Gallstone disease can manifest in a number of ways. Most patients have a history of obesity, multiple pregnancies, use of oral contraceptive pills, age of 40 years old and over, female and of Caucasian or Native American race. Some patients may be in a physical state that favors the development of gallstones but don't develop them, some patients may have gallstones, but are asymptomatic. These gallstones are detected incidentally. Some may have gallstones and experience biliary colic, nausea, vomiting and diarrhea, whilst others will have complications due to gallstones, such as acute cholecystitis and acute pancreatitis.

History and Symptoms

History

  • Obtaining history is an important aspect of making a diagnosis of gallstone disease.[1][2]

Common Symptoms

Less Common Symptoms

Less common symptoms include:[5]

References

  1. 1.0 1.1 Diehl AK, Sugarek NJ, Todd KH (1990). "Clinical evaluation for gallstone disease: usefulness of symptoms and signs in diagnosis". Am. J. Med. 89 (1): 29–33. PMID 2368790.
  2. Johnson CD (2001). "ABC of the upper gastrointestinal tract. Upper abdominal pain: Gall bladder". BMJ. 323 (7322): 1170–3. PMC 1121646. PMID 11711412.
  3. "Gallstones". Medline Plus. Retrieved 2007-08-25.
  4. LUND J (1960). "Surgical indications in cholelithiasis: prophylactic choleithiasis: prophylactic cholecystectomy elucidated on the basis of long-term follow up on 526 nonoperated cases". Ann. Surg. 151: 153–62. PMC 1613279. PMID 13848582.
  5. Berger MY, Olde Hartman TC, Bohnen AM (2003). "Abdominal symptoms: do they disappear after cholecystectomy?". Surg Endosc. 17 (11): 1723–8. doi:10.1007/s00464-002-9154-6. PMID 12802649.

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