GPSM2

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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G-protein-signaling modulator 2, also called LGN for its 10 Leucine-Glycine-Asparagine repeats, is a protein that in humans is encoded by the GPSM2 gene.[1][2][3]

Function

Heterotrimeric G proteins transduce extracellular signals received by cell surface receptors into integrated cellular responses. GPSM2 belongs to a group of proteins that modulate activation of G proteins (Blumer et al., 2002).[supplied by OMIM][3]

Interactions

GPSM2 has been shown to interact with nuclear mitotic apparatus protein 1[4] and GNAI2.[2][5]

References

  1. Blumer JB, Chandler LJ, Lanier SM (Apr 2002). "Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis". J. Biol. Chem. 277 (18): 15897–903. doi:10.1074/jbc.M112185200. PMID 11832491.
  2. 2.0 2.1 Mochizuki N, Cho G, Wen B, Insel PA (1996). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene. 181 (1–2): 39–43. doi:10.1016/S0378-1119(96)00456-8. PMID 8973305.
  3. 3.0 3.1 "Entrez Gene: GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans)".
  4. Du Q, Stukenberg PT, Macara IG (Dec 2001). "A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization". Nat. Cell Biol. 3 (12): 1069–75. doi:10.1038/ncb1201-1069. PMID 11781568.
  5. Marty C, Browning DD, Ye RD (Jun 2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.

Further reading