Fusafungine: Difference between revisions

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{{drugbox
{{Drugbox
| IUPAC_name        =  
| Verifiedfields = changed
| image            =  
| verifiedrevid = 447387050
| CAS_number        = 1393-87-9
| IUPAC_name =
| ATC_prefix        = R02
| image =
| ATC_suffix        = AB03
 
| PubChem          =
<!--Clinical data-->
| DrugBank          =
| tradename =   
| C = 29 | H = 51 | N = 2 | O = 8
| Drugs.com = {{drugs.com|international|fusafungine}}
| molecular_weight =
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| synonyms          = Fusafungin
| pregnancy_US = <!-- A / B            / C / D / X -->
| bioavailability  =
| pregnancy_category =   
| protein_bound    =
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| metabolism        =
| legal_CA = <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| elimination_half-life =
| legal_UK = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| excretion        =
| legal_US = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| pregnancy_AU     = <!-- A / B1 / B2 / B3 / C / D / X -->
| legal_status =
| pregnancy_US     = <!-- A / B            / C / D / X -->
| routes_of_administration =
| pregnancy_category=   
 
| legal_AU         = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
<!--Pharmacokinetic data-->
| legal_CA         = <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| bioavailability = 
| legal_UK         = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| protein_bound = 
| legal_US         = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| metabolism = 
| legal_status     =  
| elimination_half-life = 
| routes_of_administration =  
| excretion =
 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 1393-87-9
| ATC_prefix = R02
| ATC_suffix = AB03
| PubChem = 
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB08965
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 65DD690W0C
| KEGG_Ref = {{keggcite|changed|kegg}}
| KEGG = D08002
 
<!--Chemical data-->
| C=29 | H=51 | N=2 | O=8
| molecular_weight = 555.72 g/mol<ref>[http://www.nlm.nih.gov/cgi/mesh/2008/MB_cgi?term=Fusafungin&field=all Fusafungine] at [[Medical Subject Headings|MeSH]]</ref>
| synonyms = Fusafungin
}}
}}
{{SI}}
'''Fusafungine''' ([[International Nonproprietary Name|INN]]), also known as '''fusafungin''', is an active agent used in [[antibiotic]]s for treatment of [[nasal infection|nasal]] and [[throat infection]]. It also possesses [[anti-inflammatory]] properties. Fusafungine is a mixture of [[enniatin]] [[depsipeptide|cyclohexadepsipeptides]] made up of alternating <small>D</small>-α-hydroxyvaleric acid and <small>L</small>-''N''-methylamino acid residues,<ref>{{cite journal | journal = [[Biochemical Pharmacology]] | volume =50 |issue=12 22 |year=1995 |pages= 2105–2107 | title=Alkali cation transport through liposomes by the antimicrobial fusafungine and its constitutive enniatins | author = Daniel Levy, Aline Bluzat, Michel Seigneuret and Jean-Louis Rigaud| doi = 10.1016/0006-2952(95)02045-4 | pmid=8849339}}</ref> produced by the [[Ascomycota|ascomycete]] ''[[Fusarium lateritium]]'', and marketed by [[Servier]] under the trade names '''Locabiotal''', '''Bioparox''', and '''Locabiosol'''.
{{CMG}}


According to a pooled analysis study done in the UK for the efficacy of fusafungine in [[Rhinopharyngitis|rhinopharingitis]], it was found that the proportion of patients who showed an improvement in symptoms from Day 0 to Day 4 of infection was 61.5% with fusafungine vs. 46.8% when compared to a placebo.<ref>{{cite pmid|15626253}}</ref>


 
==References==
==Overview==
{{reflist}}
'''Fusafungine''' ([[International Nonproprietary Name|INN]]), also known as '''fusafungin''', is an active agent used in [[antibiotic]]s for treatment of nasal and throat infection. It also possesses [[anti-inflammatory]] properties. It is produced by the [[Ascomycota|ascomycete]] ''Fusarium lateririum'', and marketed by [[Servier]] under the trade name '''Locabiotal''' and Bioparox - in Austria, Germany and Switzerland under the tade name '''Locabiosol'''.


{{Throat preparations}}
{{Throat preparations}}
<br>


[[Category:Antibiotics]]
[[Category:Antimicrobial peptides]]
[[Category:Antimicrobial peptides]]
[[Category:Depsipeptides]]




[[fr:Fusafungine]]
{{antibiotic-stub}}
[[hu:Fusafungin]]
{{respiratory-system-drug-stub}}
[[pl:Fusafungina]]
 
{{WH}}
{{WS}}

Revision as of 16:33, 13 April 2015

Fusafungine
Clinical data
SynonymsFusafungin
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
DrugBank
UNII
KEGG
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC29H51N2O8
Molar mass555.72 g/mol[1]
 ☒N☑Y (what is this?)  (verify)

Fusafungine (INN), also known as fusafungin, is an active agent used in antibiotics for treatment of nasal and throat infection. It also possesses anti-inflammatory properties. Fusafungine is a mixture of enniatin cyclohexadepsipeptides made up of alternating D-α-hydroxyvaleric acid and L-N-methylamino acid residues,[2] produced by the ascomycete Fusarium lateritium, and marketed by Servier under the trade names Locabiotal, Bioparox, and Locabiosol.

According to a pooled analysis study done in the UK for the efficacy of fusafungine in rhinopharingitis, it was found that the proportion of patients who showed an improvement in symptoms from Day 0 to Day 4 of infection was 61.5% with fusafungine vs. 46.8% when compared to a placebo.[3]

References

  1. ↑ Fusafungine at MeSH
  2. ↑ Daniel Levy, Aline Bluzat, Michel Seigneuret and Jean-Louis Rigaud (1995). "Alkali cation transport through liposomes by the antimicrobial fusafungine and its constitutive enniatins". Biochemical Pharmacology. 50 (12 22): 2105–2107. doi:10.1016/0006-2952(95)02045-4. PMID 8849339.
  3. ↑ PMID 15626253 (PMID 15626253)
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Template:Throat preparations


Template:Antibiotic-stub Template:Respiratory-system-drug-stub

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