FABP1

Fatty acid binding protein 1, liver
PDB rendering based on 2f73.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2f73​
Identifiers
Symbols	FABP1 ; FABPL; L-FABP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1106
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fatty acid binding protein 1, liver, also known as FABP1, is a human gene.

FABP1 encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP1 and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.

Further reading

• Glatz JF, Börchers T, Spener F, van der Vusse GJ (1995). "Fatty acids in cell signalling: modulation by lipid binding proteins". Prostaglandins Leukot. Essent. Fatty Acids. 52 (2–3): 121–7. PMID 7784447.CS1 maint: Multiple names: authors list (link)
• Kaikaus RM, Chan WK, Ortiz de Montellano PR, Bass NM (1993). "Mechanisms of regulation of liver fatty acid-binding protein". Mol. Cell. Biochem. 123 (1–2): 93–100. PMID 8232272.CS1 maint: Multiple names: authors list (link)
• Londraville RL (1997). "Intracellular fatty acid-binding proteins: putting lower vertebrates in perspective". Braz. J. Med. Biol. Res. 29 (6): 707–20. PMID 9070383.
• Börchers T, Hohoff C, Buhlmann C, Spener F (1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation". Prostaglandins Leukot. Essent. Fatty Acids. 57 (1): 77–84. PMID 9250612.CS1 maint: Multiple names: authors list (link)
• Carroll SL, Roth KA, Gordon JI (1990). "Liver fatty acid-binding protein: a marker for studying cellular differentiation in gut epithelial neoplasms". Gastroenterology. 99 (6): 1727–35. PMID 1699834.CS1 maint: Multiple names: authors list (link)
• Sweetser DA, Birkenmeier EH, Klisak IJ; et al. (1987). "The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships". J. Biol. Chem. 262 (33): 16060–71. PMID 2824476.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen SH, Van Tuinen P, Ledbetter DH; et al. (1986). "Human liver fatty acid binding protein gene is located on chromosome 2". Somat. Cell Mol. Genet. 12 (3): 303–6. PMID 3012800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan L, Wei CF, Li WH; et al. (1985). "Human liver fatty acid binding protein cDNA and amino acid sequence. Functional and evolutionary implications". J. Biol. Chem. 260 (5): 2629–32. PMID 3838309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lowe JB, Boguski MS, Sweetser DA; et al. (1985). "Human liver fatty acid binding protein. Isolation of a full length cDNA and comparative sequence analyses of orthologous and paralogous proteins". J. Biol. Chem. 260 (6): 3413–7. PMID 3838313.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murphy EJ (1998). "L-FABP and I-FABP expression increase NBD-stearate uptake and cytoplasmic diffusion in L cells". Am. J. Physiol. 275 (2 Pt 1): G244–9. PMID 9688651.
• Wolfrum C, Börchers T, Sacchettini JC, Spener F (2000). "Binding of fatty acids and peroxisome proliferators to orthologous fatty acid binding proteins from human, murine, and bovine liver". Biochemistry. 39 (6): 1469–74. PMID 10684629.CS1 maint: Multiple names: authors list (link)
• Wolfrum C, Borrmann CM, Borchers T, Spener F (2001). "Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2323–8. doi:10.1073/pnas.051619898. PMID 11226238.CS1 maint: Multiple names: authors list (link)
• Schroeder F, Atshaves BP, Starodub O; et al. (2001). "Expression of liver fatty acid binding protein alters growth and differentiation of embryonic stem cells". Mol. Cell. Biochem. 219 (1–2): 127–38. PMID 11354243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zimmerman AW, van Moerkerk HT, Veerkamp JH (2001). "Ligand specificity and conformational stability of human fatty acid-binding proteins". Int. J. Biochem. Cell Biol. 33 (9): 865–76. PMID 11461829.CS1 maint: Multiple names: authors list (link)
• Mésange F, Sebbar M, Capdevielle J; et al. (2003). "Identification of two tamoxifen target proteins by photolabeling with 4-(2-morpholinoethoxy)benzophenone". Bioconjug. Chem. 13 (4): 766–72. PMID 12121132.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)