F-box protein

F-box proteins are proteins containing at least one F-box motif, a protein structural motif of about 50 amino acids that mediates protein-protein interactions. The first identified F-box protein is one of three components of the SCF complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome. F-box motifs commonly exist in proteins in concert with other protein-protein interaction motifs such as leucine-rich repeats and WD repeats.^[1]

F-box proteins have also been associated with cellular functions such as signal transduction and regulation of the cell cycle.^[2] In plants, many F-box proteins are represented in gene networks broadly regulated by microRNA-mediated gene silencing via RNA interference.^[3]

References

↑ Kipreos ET, Pagano M. (2000). The F-box protein family. Genome Biol 1(5):REVIEWS3002. PMID 11178263
↑ Craig KL, Tyers M. (1999). The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction. Prog Biophys Mol Biol 72(3):299-328. PMID 10581972
↑ Jones-Rhoades M, Bartel D, Bartel B. "MicroRNAS and their regulatory roles in plants". Annu Rev Plant Biol 57: 19-53. PMID 16669754

This protein-related article is a stub. You can help WikiDoc by expanding it.

v • d • e Proteins: carrier proteins
Hormone	Follistatin - Growth hormone binding protein - Insulin-like growth factor binding protein - Neurophysins (Neurophysin I, II) Sex hormone binding globulin/Androgen binding protein - Transcortin - Thyroxine-binding globulin - Transthyretin
Metal/element	calcium (Calcium-binding protein, Calmodulin-binding proteins) - copper (Ceruloplasmin) - iron (Iron-binding proteins, Transferrin receptor)
Vitamin	Retinol binding protein (4) - Transcobalamin
Other	Acyl carrier protein - Adaptor protein - Cholesterylester transfer protein - F-box protein - GTP-binding protein - Latent TGF-beta binding protein - Light-harvesting complex - Membrane transport protein