View source for Esthesioneuroblastoma epidemiology and demographics

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{{Esthesioneuroblastoma}}
{{CMG}}{{AE}}{{Simrat}}
==Overview==
The incidence of esthesioneuroblastoma is approximately 0.4 per 100,000 individuals worldwide. Esthesioneuroblastoma can present in a wide range of age groups; however, it is mostly noted in a bimodal distribution, occurring most frequently in the second and sixth decades of life. There is no racial predilection to esthesioneuroblastoma.<ref name="ShirzadiDrazin2013">{{cite journal|last1=Shirzadi|first1=Ali S.|last2=Drazin|first2=Doniel G.|last3=Strickland|first3=Allison S.|last4=Bannykh|first4=Serguei I.|last5=Johnson|first5=J. Patrick|title=Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup|journal=Case Reports in Surgery|volume=2013|year=2013|pages=1–8|issn=2090-6900|doi=10.1155/2013/107315}}</ref><ref name="radio"> Esthesioneuroblastoma. Radiopedia(2015) http://radiopaedia.org/articles/olfactory-neuroblastoma Accessed on January 25, 2016</ref> Males are more commonly affected with esthesioneuroblastoma than females. The male to female ratio is approximately 1.2 to 1.<ref name="pmid19721769">{{cite journal| author=Ward PD, Heth JA, Thompson BG, Marentette LJ| title=Esthesioneuroblastoma: Results and Outcomes of a Single Institution's Experience. | journal=Skull Base | year= 2009 | volume= 19 | issue= 2 | pages= 133-40 | pmid=19721769 | doi=10.1055/s-0028-1096195 | pmc=PMC2671304 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19721769  }} </ref><ref name="pmid15654688">{{cite journal| author=Diaz EM, Johnigan RH, Pero C, El-Naggar AK, Roberts DB, Barker JL et al.| title=Olfactory neuroblastoma: the 22-year experience at one comprehensive cancer center. | journal=Head Neck | year= 2005 | volume= 27 | issue= 2 | pages= 138-49 | pmid=15654688 | doi=10.1002/hed.20127 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15654688  }} </ref><ref name="pmid10941155">{{cite journal| author=Resto VA, Eisele DW, Forastiere A, Zahurak M, Lee DJ, Westra WH| title=Esthesioneuroblastoma: the Johns Hopkins experience. | journal=Head Neck | year= 2000 | volume= 22 | issue= 6 | pages= 550-8 | pmid=10941155 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10941155  }} </ref><ref name="pmid18798301">{{cite journal| author=Bachar G, Goldstein DP, Shah M, Tandon A, Ringash J, Pond G et al.| title=Esthesioneuroblastoma: The Princess Margaret Hospital experience. | journal=Head Neck | year= 2008 | volume= 30 | issue= 12 | pages= 1607-14 | pmid=18798301 | doi=10.1002/hed.20920 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18798301  }} </ref>

==Epidemiology and Demographics==
Esthesioneuroblastoma is noted in 4 out of 10 million individuals, accounting for 5% of sinonasal and 3% of [[intracranial]] [[tumors]].<ref name="ShirzadiDrazin2013">{{cite journal|last1=Shirzadi|first1=Ali S.|last2=Drazin|first2=Doniel G.|last3=Strickland|first3=Allison S.|last4=Bannykh|first4=Serguei I.|last5=Johnson|first5=J. Patrick|title=Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup|journal=Case Reports in Surgery|volume=2013|year=2013|pages=1–8|issn=2090-6900|doi=10.1155/2013/107315}}</ref> Approximately 1,000 cases have been identified since Berger and Luc described the first case in 1924.<ref name="pmid9252701">{{cite journal| author=Broich G, Pagliari A, Ottaviani F| title=Esthesioneuroblastoma: a general review of the cases published since the discovery of the tumour in 1924. | journal=Anticancer Res | year= 1997 | volume= 17 | issue= 4A | pages= 2683-706 | pmid=9252701 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9252701  }} </ref> According to the BBC, only 201 cases of the disease have been recorded worldwide in the past two decades. A 1997 literature search identified 1,457 cases in the published literature since its discovery in 1924, however 487 were cited in more than one paper, bringing the total of reported cases to 945.<ref name="wiki"> Esthesioneuroblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Esthesioneuroblastoma Accessed on January 26, 2016</ref >

==Incidence==
The incidence of esthesioneuroblastoma was estimated to be 0.4 cases per 100,000 individuals worldwide. 
==Age==
Esthesioneuroblastoma commonly affects individuals in a wide range of age groups (3-90 years of age). There is a bimodal peak of occurrence in the third and sixth decades of life. The majority of cases of esthesioneuroblastoma occur in patients between 40 and 70 years of age; the median age at diagnosis is 53 years.

==Race==
There is no racial predilection to esthesioneuroblastoma.

==Gender==
Males are more commonly affected with esthesioneuroblastoma than females. The male to female ratio is approximately 1.2 to 1.<ref name="pmid19721769">{{cite journal| author=Ward PD, Heth JA, Thompson BG, Marentette LJ| title=Esthesioneuroblastoma: Results and Outcomes of a Single Institution's Experience. | journal=Skull Base | year= 2009 | volume= 19 | issue= 2 | pages= 133-40 | pmid=19721769 | doi=10.1055/s-0028-1096195 | pmc=PMC2671304 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19721769  }} </ref><ref name="pmid15654688">{{cite journal| author=Diaz EM, Johnigan RH, Pero C, El-Naggar AK, Roberts DB, Barker JL et al.| title=Olfactory neuroblastoma: the 22-year experience at one comprehensive cancer center. | journal=Head Neck | year= 2005 | volume= 27 | issue= 2 | pages= 138-49 | pmid=15654688 | doi=10.1002/hed.20127 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15654688  }} </ref><ref name="pmid10941155">{{cite journal| author=Resto VA, Eisele DW, Forastiere A, Zahurak M, Lee DJ, Westra WH| title=Esthesioneuroblastoma: the Johns Hopkins experience. | journal=Head Neck | year= 2000 | volume= 22 | issue= 6 | pages= 550-8 | pmid=10941155 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10941155  }} </ref><ref name="pmid18798301">{{cite journal| author=Bachar G, Goldstein DP, Shah M, Tandon A, Ringash J, Pond G et al.| title=Esthesioneuroblastoma: The Princess Margaret Hospital experience. | journal=Head Neck | year= 2008 | volume= 30 | issue= 12 | pages= 1607-14 | pmid=18798301 | doi=10.1002/hed.20920 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18798301  }} </ref>

==References==
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[[Category:Disease]]
[[Category:Types of cancer]]
[[Category:neurology]]
[[Category:Rhinology]]

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