Endometrial hyperplasia history and symptoms: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(7 intermediate revisions by 5 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Endometrial hyperplasia}}
{{Endometrial hyperplasia}}
{{CMG}}{{AE}} {{STM}}
{{CMG}}{{Swathi}}


==Overview==
==Overview==
A positive history of  irregular menstrual cycles (PCOS) may be present.<ref name=qw>Endometrial hyperplasia. Radiopedia. http://radiopaedia.org/articles/endometrial-hyperplasia-1 Accessed on March 10, 2016.</ref> A detailed drug history may be helpful in the assessment of possible risk factors for endometrial hyperplasia. A history of inappropriate hormone replacement therapy in post menopausal women and history of tamoxifen use in breast cancer patients may be present.<ref name="pmid25797956">{{cite journal| author=Emons G, Beckmann MW, Schmidt D, Mallmann P, Uterus commission of the Gynecological Oncology Working Group (AGO)| title=New WHO Classification of Endometrial Hyperplasias. | journal=Geburtshilfe Frauenheilkd | year= 2015 | volume= 75 | issue= 2 | pages= 135-136 | pmid=25797956 | doi=10.1055/s-0034-1396256 | pmc=PMC4361167 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25797956  }} </ref><ref name="pmid19393600">{{cite journal| author=Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, Allison K et al.| title=Incidence of endometrial hyperplasia. | journal=Am J Obstet Gynecol | year= 2009 | volume= 200 | issue= 6 | pages= 678.e1-6 | pmid=19393600 | doi=10.1016/j.ajog.2009.02.032 | pmc=PMC2692753 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19393600  }} </ref><ref name=mn>Tamoxifen associated endometrial changes. Radiopedia. http://radiopaedia.org/articles/tamoxifen-associated-endometrial-changes Accessed on March 10, 2016</ref>
A positive [[History and Physical examination|history]] of  irregular [[menstrual cycle]]s ([[PCOD]]) may be [[Presenting symptoms|present]].<ref name="qw">Endometrial hyperplasia. Radiopedia. http://radiopaedia.org/articles/endometrial-hyperplasia-1 Accessed on March 10, 2016.</ref> A detailed drug history may be helpful in the assessment of possible [[risk factors]] for [[endometrial hyperplasia]]. A history of inappropriate [[hormone replacement therapy]] in [[Postmenopausal|post menopausal]] [[women]] and [[History and Physical examination|history]] of [[tamoxifen]] use in [[breast cancer]] [[patients]] may be present.<ref name="pmid25797956">{{cite journal| author=Emons G, Beckmann MW, Schmidt D, Mallmann P, Uterus commission of the Gynecological Oncology Working Group (AGO)| title=New WHO Classification of Endometrial Hyperplasias. | journal=Geburtshilfe Frauenheilkd | year= 2015 | volume= 75 | issue= 2 | pages= 135-136 | pmid=25797956 | doi=10.1055/s-0034-1396256 | pmc=PMC4361167 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25797956  }} </ref><ref name="pmid19393600">{{cite journal| author=Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, Allison K et al.| title=Incidence of endometrial hyperplasia. | journal=Am J Obstet Gynecol | year= 2009 | volume= 200 | issue= 6 | pages= 678.e1-6 | pmid=19393600 | doi=10.1016/j.ajog.2009.02.032 | pmc=PMC2692753 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19393600  }} </ref><ref name="mn">Tamoxifen associated endometrial changes. Radiopedia. http://radiopaedia.org/articles/tamoxifen-associated-endometrial-changes Accessed on March 10, 2016</ref>


==History==
==History==
*A detailed drug history may be helpful in the assessment of possible risk factors for endometrial hyperplasia.
*Bleeding during the menstrual period that is heavier or lasts longer than usual
**Inappropriate hormone replacement therapy in post menopausal women (with insufficient progesterone component)<ref name="pmid25797956">{{cite journal| author=Emons G, Beckmann MW, Schmidt D, Mallmann P, Uterus commission of the Gynecological Oncology Working Group (AGO)| title=New WHO Classification of Endometrial Hyperplasias. | journal=Geburtshilfe Frauenheilkd | year= 2015 | volume= 75 | issue= 2 | pages= 135-136 | pmid=25797956 | doi=10.1055/s-0034-1396256 | pmc=PMC4361167 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25797956  }} </ref><ref name="pmid19393600">{{cite journal| author=Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, Allison K et al.| title=Incidence of endometrial hyperplasia. | journal=Am J Obstet Gynecol | year= 2009 | volume= 200 | issue= 6 | pages= 678.e1-6 | pmid=19393600 | doi=10.1016/j.ajog.2009.02.032 | pmc=PMC2692753 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19393600  }} </ref>
*Menstrual cycles that are shorter than 21 days (counting from the first day of the menstrual period to the first day of the next menstrual period)
**History of tamoxifen use<ref name=mn>Tamoxifen associated endometrial changes. Radiopedia. http://radiopaedia.org/articles/tamoxifen-associated-endometrial-changes Accessed on March 10, 2016</ref>
*Any bleeding after menopause
***Tamoxifen is a non-steroidal anti-estrogen that binds to the estrogen receptor and is used primarily for adjuvant therapy in breast cancer
*A detailed [[drug]] [[History and Physical examination|history]] may be helpful in the [[Assessment and Plan|assessment]] of possible [[risk factors]] for [[endometrial hyperplasia]].
***Tamoxifen may also act as an estrogen agonist in a low estradiol environment
**Inappropriate [[hormone replacement therapy]] in post [[menopausal]] [[women]] (with insufficient [[progesterone]] component)<ref name="pmid25797956">{{cite journal| author=Emons G, Beckmann MW, Schmidt D, Mallmann P, Uterus commission of the Gynecological Oncology Working Group (AGO)| title=New WHO Classification of Endometrial Hyperplasias. | journal=Geburtshilfe Frauenheilkd | year= 2015 | volume= 75 | issue= 2 | pages= 135-136 | pmid=25797956 | doi=10.1055/s-0034-1396256 | pmc=PMC4361167 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25797956  }} </ref><ref name="pmid19393600">{{cite journal| author=Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, Allison K et al.| title=Incidence of endometrial hyperplasia. | journal=Am J Obstet Gynecol | year= 2009 | volume= 200 | issue= 6 | pages= 678.e1-6 | pmid=19393600 | doi=10.1016/j.ajog.2009.02.032 | pmc=PMC2692753 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19393600  }} </ref>
***Up to 50% of breast cancer patients who are treated with tamoxifen may develop an endometrial lesion within 6-36 months  
**History of [[tamoxifen]] use<ref name="mn">Tamoxifen associated endometrial changes. Radiopedia. http://radiopaedia.org/articles/tamoxifen-associated-endometrial-changes Accessed on March 10, 2016</ref>
***Any patient who develops bleeding while on tamoxifen needs evaluation
***[[Tamoxifen]] is a [[non-steroidal]] [[Anti-estrogen therapy|anti-estrogen]] that binds to the [[estrogen]] [[receptor]] and is used primarily for [[adjuvant therapy]] in [[breast cancer]]
*A positive history of  irregular menstrual cycles (PCOS) may be present.<ref name=qw>Endometrial hyperplasia. Radiopedia. http://radiopaedia.org/articles/endometrial-hyperplasia-1 Accessed on March 10, 2016.</ref>
***[[Tamoxifen]] may also act as an [[estrogen]] [[agonist]] in a low [[estradiol]] environment
***Up to 50% of [[breast cancer]] [[patients]] who are treated with [[tamoxifen]] may develop an [[endometrial]] [[Lesions|lesion]] within 6-36 months  
***Any [[patient]] who [[Development|develops]] [[bleeding]] while on [[tamoxifen]] needs evaluation
*A positive [[History and Physical examination|history]] of  irregular [[menstrual cycle]]s ([[PCOD]]) may be present.<ref name="qw">Endometrial hyperplasia. Radiopedia. http://radiopaedia.org/articles/endometrial-hyperplasia-1 Accessed on March 10, 2016.</ref>
We observed an association between [[Endometrial hyperplasia|EH]]/[[Endometrial cancer|EC]] and a [[History and Physical examination|history]] of [[gestational diabetes]] specific to younger [[women]]. Future studies focusing on the relationships between [[gestational diabetes]], [[obesity]], and [[Endometrial cancer|EC]], including [[age]] at [[diagnosis]], are warranted.<ref name="pmid28577154">{{cite journal |vauthors=Wartko PD, Beck TL, Reed SD, Mueller BA, Hawes SE |title=Association of endometrial hyperplasia and cancer with a history of gestational diabetes |journal=Cancer Causes Control |volume=28 |issue=8 |pages=819–828 |date=August 2017 |pmid=28577154 |doi=10.1007/s10552-017-0908-9 |url=}}</ref>


==Symptoms==
==Symptoms==
*The majority of patients with endometrial hyperplasia present with abnormal uterine bleeding.<ref name=qw>Endometrial hyperplasia. Radiopedia. http://radiopaedia.org/articles/endometrial-hyperplasia-1 Accessed on March 10, 2016.</ref>
*The majority of [[patients]] with [[endometrial hyperplasia]] present with [[abnormal uterine bleeding]].<ref name="qw">Endometrial hyperplasia. Radiopedia. http://radiopaedia.org/articles/endometrial-hyperplasia-1 Accessed on March 10, 2016.</ref>
*Any postmenopausal bleeding should raise a suspicion for malignancy.
*Any [[postmenopausal]] [[bleeding]] should raise suspicion for [[malignancy]].


==References==
==References==
Line 28: Line 32:
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Gynecology]]
[[Category:Surgery]]

Latest revision as of 13:08, 13 May 2019

Endometrial hyperplasia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Endometrial hyperplasia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Case Studies

Case #1

Endometrial hyperplasia history and symptoms On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Endometrial hyperplasia history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Endometrial hyperplasia history and symptoms

CDC on Endometrial hyperplasia history and symptoms

Endometrial hyperplasia history and symptoms in the news

Blogs on Endometrial hyperplasia history and symptoms

Directions to Hospitals Treating Endometrial hyperplasia

Risk calculators and risk factors for Endometrial hyperplasia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Swathi Venkatesan, M.B.B.S.[2]

Overview

A positive history of irregular menstrual cycles (PCOD) may be present.[1] A detailed drug history may be helpful in the assessment of possible risk factors for endometrial hyperplasia. A history of inappropriate hormone replacement therapy in post menopausal women and history of tamoxifen use in breast cancer patients may be present.[2][3][4]

History

We observed an association between EH/EC and a history of gestational diabetes specific to younger women. Future studies focusing on the relationships between gestational diabetes, obesity, and EC, including age at diagnosis, are warranted.[5]

Symptoms

References

  1. 1.0 1.1 1.2 Endometrial hyperplasia. Radiopedia. http://radiopaedia.org/articles/endometrial-hyperplasia-1 Accessed on March 10, 2016.
  2. 2.0 2.1 Emons G, Beckmann MW, Schmidt D, Mallmann P, Uterus commission of the Gynecological Oncology Working Group (AGO) (2015). "New WHO Classification of Endometrial Hyperplasias". Geburtshilfe Frauenheilkd. 75 (2): 135–136. doi:10.1055/s-0034-1396256. PMC 4361167. PMID 25797956.
  3. 3.0 3.1 Reed SD, Newton KM, Clinton WL, Epplein M, Garcia R, Allison K; et al. (2009). "Incidence of endometrial hyperplasia". Am J Obstet Gynecol. 200 (6): 678.e1–6. doi:10.1016/j.ajog.2009.02.032. PMC 2692753. PMID 19393600.
  4. 4.0 4.1 Tamoxifen associated endometrial changes. Radiopedia. http://radiopaedia.org/articles/tamoxifen-associated-endometrial-changes Accessed on March 10, 2016
  5. Wartko PD, Beck TL, Reed SD, Mueller BA, Hawes SE (August 2017). "Association of endometrial hyperplasia and cancer with a history of gestational diabetes". Cancer Causes Control. 28 (8): 819–828. doi:10.1007/s10552-017-0908-9. PMID 28577154.

Template:WikiDoc Sources