EPHB3

EPH receptor B3
Identifiers
Symbol(s)	EPHB3; ETK2; HEK2; TYRO6
External IDs	OMIM: 601839 MGI: 104770 Homologene: 20938
Gene ontology Molecular Function: • nucleotide binding • receptor activity • ephrin receptor activity • ATP binding • axon guidance receptor activity • transferase activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • protein amino acid phosphorylation • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • axon guidance
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2049	13845
Ensembl	ENSG00000182580	ENSMUSG00000005958
Uniprot	P54753	Q60669
Refseq	NM_004443 (mRNA) NP_004434 (protein)	NM_010143 (mRNA) NP_034273 (protein)
Location	Chr 3: 185.76 - 185.78 Mb	Chr 16: 21.12 - 21.14 Mb
Pubmed search	[1]	[2]

EPH receptor B3, also known as EPHB3, is a human gene.

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development.". Annu. Rev. Neurosci. 21: 309-45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499.
• Zhou R (1998). "The Eph family receptors and ligands.". Pharmacol. Ther. 77 (3): 151-81. PMID 9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis.". Development 126 (10): 2033-44. PMID 10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly.". Int. Rev. Cytol. 196: 177-244. PMID 10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993-1002. doi:10.1098/rstb.2000.0635. PMID 11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development.". Nat. Rev. Neurosci. 2 (3): 155-64. PMID 11256076.
• Böhme B, Holtrich U, Wolf G, et al. (1993). "PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2.". Oncogene 8 (10): 2857-62. PMID 8397371.
• Böhme B, VandenBos T, Cerretti DP, et al. (1996). "Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.". J. Biol. Chem. 271 (40): 24747-52. PMID 8798744.
• (1997) "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.". Cell 90 (3): 403-4. PMID 9267020.
• Bergemann AD, Zhang L, Chiang MK, et al. (1998). "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube.". Oncogene 16 (4): 471-80. doi:10.1038/sj.onc.1201557. PMID 9484836.
• Hock B, Böhme B, Karn T, et al. (1998). "Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.". Oncogene 17 (2): 255-60. doi:10.1038/sj.onc.1201907. PMID 9674711.
• Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779-84. PMID 9707552.
• Ciossek T, Monschau B, Kremoser C, et al. (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro.". Eur. J. Neurosci. 10 (5): 1574-80. PMID 9751130.
• Adams RH, Wilkinson GA, Weiss C, et al. (1999). "Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.". Genes Dev. 13 (3): 295-306. PMID 9990854.