EGLN1

Egl nine homolog 1 (C. elegans)
PDB rendering based on 2g19.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2g19​, 2g1m​, 2hbt​, 2hbu​
Identifiers
Symbols	EGLN1 ; C1orf12; DKFZp761F179; ECYT3; HIFPH2; PHD2; SM-20; SM20; ZMYND6
External IDs	Template:OMIM5 HomoloGene: 56936
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Egl nine homolog 1 (C. elegans), also known as EGLN1, is a human gene.

Further reading

• Semenza GL (2001). "HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus". Cell. 107 (1): 1–3. PMID 11595178.
• Wax SD, Tsao L, Lieb ME; et al. (1996). "SM-20 is a novel 40-kd protein whose expression in the arterial wall is restricted to smooth muscle". Lab. Invest. 74 (4): 797–808. PMID 8606489.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dupuy D, Aubert I, Dupérat VG; et al. (2001). "Mapping, characterization, and expression analysis of the SM-20 human homologue, c1orf12, and identification of a novel related gene, SCAND2". Genomics. 69 (3): 348–54. doi:10.1006/geno.2000.6343. PMID 11056053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taylor MS (2001). "Characterization and comparative analysis of the EGLN gene family". Gene. 275 (1): 125–32. PMID 11574160.
• Epstein AC, Gleadle JM, McNeill LA; et al. (2001). "C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation". Cell. 107 (1): 43–54. PMID 11595184.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oehme F, Ellinghaus P, Kolkhof P; et al. (2002). "Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors". Biochem. Biophys. Res. Commun. 296 (2): 343–9. PMID 12163023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ivan M, Haberberger T, Gervasi DC; et al. (2002). "Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13459–64. doi:10.1073/pnas.192342099. PMID 12351678.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Metzen E, Berchner-Pfannschmidt U, Stengel P; et al. (2003). "Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing". J. Cell. Sci. 116 (Pt 7): 1319–26. PMID 12615973.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cioffi CL, Liu XQ, Kosinski PA; et al. (2003). "Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells". Biochem. Biophys. Res. Commun. 303 (3): 947–53. PMID 12670503.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berra E, Benizri E, Ginouvès A; et al. (2003). "HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia". EMBO J. 22 (16): 4082–90. doi:10.1093/emboj/cdg392. PMID 12912907.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aprelikova O, Chandramouli GV, Wood M; et al. (2004). "Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors". J. Cell. Biochem. 92 (3): 491–501. doi:10.1002/jcb.20067. PMID 15156561.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Appelhoff RJ, Tian YM, Raval RR; et al. (2004). "Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor". J. Biol. Chem. 279 (37): 38458–65. doi:10.1074/jbc.M406026200. PMID 15247232.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Metzen E, Stiehl DP, Doege K; et al. (2006). "Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element". Biochem. J. 387 (Pt 3): 711–7. doi:10.1042/BJ20041736. PMID 15563275.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baek JH, Mahon PC, Oh J; et al. (2005). "OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha". Mol. Cell. 17 (4): 503–12. doi:10.1016/j.molcel.2005.01.011. PMID 15721254.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ozer A, Wu LC, Bruick RK (2005). "The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7481–6. doi:10.1073/pnas.0502716102. PMID 15897452.CS1 maint: Multiple names: authors list (link)
• Choi KO, Lee T, Lee N; et al. (2006). "Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger". Mol. Pharmacol. 68 (6): 1803–9. doi:10.1124/mol.105.015271. PMID 16155211.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• To KK, Huang LE (2006). "Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1". J. Biol. Chem. 280 (45): 38102–7. doi:10.1074/jbc.M504342200. PMID 16157596.
• Kato H, Inoue T, Asanoma K; et al. (2006). "Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1". Int. J. Cancer. 118 (5): 1144–53. doi:10.1002/ijc.21488. PMID 16161047.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)