Dutasteride

Revision as of 19:56, 27 September 2011 by WikiBot (talk | contribs) (Protected "Dutasteride": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite)))
Jump to navigation Jump to search
Dutasteride
Clinical data
Pregnancy
category
  • US: X (Contraindicated)
  • Not to be handled by pregnant women
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability60%
Protein binding99%
MetabolismHepatic (CYP3A4-mediated)
Elimination half-life5 weeks
ExcretionFecal
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC27H30F6N2O2
Molar mass528.53 g/mol

WikiDoc Resources for Dutasteride

Articles

Most recent articles on Dutasteride

Most cited articles on Dutasteride

Review articles on Dutasteride

Articles on Dutasteride in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Dutasteride

Images of Dutasteride

Photos of Dutasteride

Podcasts & MP3s on Dutasteride

Videos on Dutasteride

Evidence Based Medicine

Cochrane Collaboration on Dutasteride

Bandolier on Dutasteride

TRIP on Dutasteride

Clinical Trials

Ongoing Trials on Dutasteride at Clinical Trials.gov

Trial results on Dutasteride

Clinical Trials on Dutasteride at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Dutasteride

NICE Guidance on Dutasteride

NHS PRODIGY Guidance

FDA on Dutasteride

CDC on Dutasteride

Books

Books on Dutasteride

News

Dutasteride in the news

Be alerted to news on Dutasteride

News trends on Dutasteride

Commentary

Blogs on Dutasteride

Definitions

Definitions of Dutasteride

Patient Resources / Community

Patient resources on Dutasteride

Discussion groups on Dutasteride

Patient Handouts on Dutasteride

Directions to Hospitals Treating Dutasteride

Risk calculators and risk factors for Dutasteride

Healthcare Provider Resources

Symptoms of Dutasteride

Causes & Risk Factors for Dutasteride

Diagnostic studies for Dutasteride

Treatment of Dutasteride

Continuing Medical Education (CME)

CME Programs on Dutasteride

International

Dutasteride en Espanol

Dutasteride en Francais

Business

Dutasteride in the Marketplace

Patents on Dutasteride

Experimental / Informatics

List of terms related to Dutasteride

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Dutasteride (marketed as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost) is a 5-alpha-reductase inhibitor, a drug which inhibits the conversion of testosterone into dihydrotestosterone (DHT). It is used to treat conditions caused by DHT, such as benign prostatic hyperplasia (BPH).

Classification and Method of Action

Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Finasteride also belongs to this group. Dutasteride inhibits both isoforms of 5-alpha reductase, while finasteride inhibits only one. But a clinical study done by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH.

Uses

While dutasteride is officially approved to treat enlargement of the prostate gland. Clinical trials for dutasteride as a hair loss drug were undertaken, but called off in late 2002. The reason the trials were called off is not publicly known. Industry sources speculate that Avodart would have been seen as too similar to Propecia to have proved profitable as a hair loss treatment.

In December 2006, Avodart manufacturer GlaxoSmithKline embarked on a new Phase III, six month study in Korea to test the safety, tolerability and effectiveness of a once-daily dose of dutasteride (0.5mg) for the treatment of male pattern baldness in the vertex region of the scalp (types IIIv, IV and V on the Hamilton-Norwood scale).[1] The future impact that this study will have on the FDA's approval or disapproval of Avodart for the treatment of male pattern baldness in the United States is yet to be determined.

See also

External links

References

  1. Clinical trial number NCT00441116 at ClinicalTrials.gov

Template:SIB

de:Dutasterid fi:Dutasteridi

Template:WH Template:WS