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__NOTOC__
__NOTOC__
{{DIC}}


{{CMG}}; {{AE}} {{OK}}
{{CMG}} {{shyam}}; {{AE}} {{OK}}
== Overview ==
== Overview ==
There is no single diagnostic study of choice for [[DIC]], though [[DIC]] may be diagnosed based on the diagnostic criteria established by Japanese Society on Thrombosis and Hemostasis.


== Diagnostic Study of Choice ==
== Diagnostic Study of Choice ==


=== Study of choice ===
=== Study of choice ===
There is no single diagnostic study of choice for the diagnosis of disseminated intravascular coagulation. DIC is a clinical as well as a laboratory diagnosis.
There is no single diagnostic study of choice for the diagnosis of [[disseminated intravascular coagulation]]. [[DIC]] is a clinical as well as a laboratory diagnosis.


=== Name of Diagnostic Criteria ===
=== Name of Diagnostic Criteria ===


'''It is recommended that you include the criteria in a table. Make sure you always cite the source of the content and whether the table has been adapted from another source.'''
There is no single diagnostic study of choice for [[DIC]], though [[DIC]] may be diagnosed based on the diagnostic criteria established by Japanese Society on Thrombosis and Hemostasis.<ref name="pmid28680365">{{cite journal |vauthors=Wada H, Takahashi H, Uchiyama T, Eguchi Y, Okamoto K, Kawasugi K, Madoiwa S, Asakura H |title=The approval of revised diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis |journal=Thromb J |volume=15 |issue= |pages=17 |date=2017 |pmid=28680365 |pmc=5496332 |doi=10.1186/s12959-017-0142-4 |url=}}</ref>


[Disease name] is primarily diagnosed based on clinical presentation. There are no established criteria for the diagnosis of [disease name].
'''JSTH’s DIC diagnostic criteria'''<ref name="pmid28680365">{{cite journal |vauthors=Wada H, Takahashi H, Uchiyama T, Eguchi Y, Okamoto K, Kawasugi K, Madoiwa S, Asakura H |title=The approval of revised diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis |journal=Thromb J |volume=15 |issue= |pages=17 |date=2017 |pmid=28680365 |pmc=5496332 |doi=10.1186/s12959-017-0142-4 |url=}}</ref>
{| class="wikitable"
|
|'''Classification of type'''
| colspan="2" |'''Basic'''
| colspan="2" |'''Hematopoietic disorder'''
| colspan="2" |'''Infectious'''
|-
| rowspan="15" |Global coagulation tests
| rowspan="5" |Platelet count (×10<sup>3</sup>/μl)
|>120
|0 p
| colspan="2" rowspan="5" |
|>120
|0 p
|-
|80 < − ≤ 120
|1 p
|80 < − ≤ 120
|1 p
|-
|50 < − ≤ 80
|2 p
|50 < − ≤ 80
|2 p
|-
|≤50
|3 p
|≤50
|3 p
|-
|≥30% decrease w/in 24 h (*1)
|<nowiki>+1 p</nowiki>
|≥30% decrease w/in 24 h (*1)
|<nowiki>+1 p</nowiki>
|-
| rowspan="4" |FDP


OR
(μg/ml)
|<10
|0 p
|<10
|0 p
|<10
|0 p
|-
|10 ≤ − < 20
|1 p
|10 ≤ − < 20
|1 p
|10 ≤ − < 20
|1 p
|-
|20 ≤ − < 40
|2 p
|20 ≤ − < 40
|2 p
|20 ≤ − < 40
|2 p
|-
|≥40
|3 p
|≥40
|3 p
|≥40
|3 p
|-
| rowspan="3" |Fibrinogen


There is no single diagnostic study of choice for [disease name], though [disease name] may be diagnosed based on [name of criteria] established by [...].
(mg/dl)
|>150
|0 p
|>150
|0 p
| colspan="2" rowspan="3" |
|-
|100 < − ≤ 150
|1 p
|100 < − ≤ 150
|1 p
|-
|≤100
|2 p
|≤100
|2 p
|-
| rowspan="3" |Prothrombin time ratio
|<1.25
|0 p
|<1.25
|0 p
|<1.25
|0 p
|-
|1.25 ≤ − < 1.67
|1 p
|1.25 ≤ − < 1.67
|1 p
|1.25 ≤ − < 1.67
|1 p
|-
|≥1.67
|2 p
|≥1.67
|2 p
|≥1.67
|2 p
|-
| rowspan="4" |Hemostatic molecular markers
| rowspan="2" |Antithrombin


OR
(%)
|>70
|0 p
|>70
|0 p
|>70
|0 p
|-
|≤70
|1 p
|≤70
|1 p
|≤70
|1 p
|-
| rowspan="2" |TAT, SF or F<sub>1+2</sub>
|<2-fold of normal upper limit
|0 p
|<2-fold of normal upper limit
|0 p
|<2-fold of normal upper limit
|0 p
|-
|≥2-fold of normal upper limit
|1 p
|≥2-fold of normal upper limit
|1 p
|≥2-fold of normal upper limit
|1 p
|-
| colspan="2" rowspan="2" |Liver failure


The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
(*2)
 
|No
OR
|0 p
 
|No
The diagnosis of [disease name] is based on the [criteria name] criteria, which includes [criterion 1], [criterion 2], and [criterion 3].
|0 p
 
|No
OR
|0 p
 
|-
[Disease name] may be diagnosed at any time if one or more of the following criteria are met:
|Yes
* Criteria 1
|−3 p
* Criteria 2
|Yes
* Criteria 3
|−3 p
 
|Yes
OR
|−3 p
 
|-
'''IF there are clear, established diagnostic criteria'''
| colspan="2" |DIC diagnosis
 
| colspan="2" |≥6 p
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
| colspan="2" |≥4 p
 
| colspan="2" |≥5 p
OR
|}
 
The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].
 
OR
 
The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].
 
OR
 
'''IF there are no established diagnostic criteria'''
 
There are no established criteria for the diagnosis of [disease name].


==References==
==References==

Latest revision as of 02:29, 24 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[3]

Overview

There is no single diagnostic study of choice for DIC, though DIC may be diagnosed based on the diagnostic criteria established by Japanese Society on Thrombosis and Hemostasis.

Diagnostic Study of Choice

Study of choice

There is no single diagnostic study of choice for the diagnosis of disseminated intravascular coagulation. DIC is a clinical as well as a laboratory diagnosis.

Name of Diagnostic Criteria

There is no single diagnostic study of choice for DIC, though DIC may be diagnosed based on the diagnostic criteria established by Japanese Society on Thrombosis and Hemostasis.[1]

JSTH’s DIC diagnostic criteria[1]

Classification of type Basic Hematopoietic disorder Infectious
Global coagulation tests Platelet count (×103/μl) >120 0 p >120 0 p
80 < − ≤ 120 1 p 80 < − ≤ 120 1 p
50 < − ≤ 80 2 p 50 < − ≤ 80 2 p
≤50 3 p ≤50 3 p
≥30% decrease w/in 24 h (*1) +1 p ≥30% decrease w/in 24 h (*1) +1 p
FDP

(μg/ml)

<10 0 p <10 0 p <10 0 p
10 ≤ − < 20 1 p 10 ≤ − < 20 1 p 10 ≤ − < 20 1 p
20 ≤ − < 40 2 p 20 ≤ − < 40 2 p 20 ≤ − < 40 2 p
≥40 3 p ≥40 3 p ≥40 3 p
Fibrinogen

(mg/dl)

>150 0 p >150 0 p
100 < − ≤ 150 1 p 100 < − ≤ 150 1 p
≤100 2 p ≤100 2 p
Prothrombin time ratio <1.25 0 p <1.25 0 p <1.25 0 p
1.25 ≤ − < 1.67 1 p 1.25 ≤ − < 1.67 1 p 1.25 ≤ − < 1.67 1 p
≥1.67 2 p ≥1.67 2 p ≥1.67 2 p
Hemostatic molecular markers Antithrombin

(%)

>70 0 p >70 0 p >70 0 p
≤70 1 p ≤70 1 p ≤70 1 p
TAT, SF or F1+2 <2-fold of normal upper limit 0 p <2-fold of normal upper limit 0 p <2-fold of normal upper limit 0 p
≥2-fold of normal upper limit 1 p ≥2-fold of normal upper limit 1 p ≥2-fold of normal upper limit 1 p
Liver failure

(*2)

No 0 p No 0 p No 0 p
Yes −3 p Yes −3 p Yes −3 p
DIC diagnosis ≥6 p ≥4 p ≥5 p

References

  1. ↑ 1.0 1.1 Wada H, Takahashi H, Uchiyama T, Eguchi Y, Okamoto K, Kawasugi K, Madoiwa S, Asakura H (2017). "The approval of revised diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis". Thromb J. 15: 17. doi:10.1186/s12959-017-0142-4. PMC 5496332. PMID 28680365.

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