Diphyllobothriasis medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2] Furqan M M. M.B.B.S[3]

Medical Therapy

• Praziquantel

Oral praziquantel is available for human use in the United States. Praziquantel increases the permeability of the cell membrane towards calcium ions. This induces contraction of the parasites, resulting in paralysis in the contracted state.

• Niclosamide

Niclosamide inhibits the oxidative phosphorylation and anaerobic metabolism in the parasites.

Antimicrobial Regimen

Shown below is a table summarizing the preferred and alternative empiric treatment for Diphyllobothriasis

Pathogens	Preferred Treatment	Duration of Treatment	Alternative Treatment
Diphyllobothrium latum	Praziquantel* Adults, 5-10 mg/kg orally in a single-dose therapy; the dosage for children is the same.	Single dose	Niclosamide Adult 2 gm orally once; children, 50 mg/kg (max 2 gm) orally once.

• Not FDA-approved for this indication.*
• (Note: praziquantel should be taken with liquids during a meal.)