Diphenyl prolinol

160px
Diphenyl prolinol
Systematic (IUPAC) name
diphenyl-[(2R)-pyrrolidin-2-yl]methanol
Identifiers
CAS number	22348-32-9
ATC code	?
PubChem	7045371
Chemical data
Formula	C17H19NO
Mol. mass	253.33886 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Diphenyl prolinol, or (R,S)(+,-)-diphenyl-2-pyrrolidinyl-methanol, is a relatively mild dopamine and norepinephrine reuptake inhibitor. The dextrorotary (R,+) enantiomer is the most pharmacologically active. Anecdotally, the dextrorotary enantiomer is orally active in the 25-100mg range, with a duration of 5-8 hours. The effects are said to be similar to other NDRIs, producing mild stimulation (at least in relation to substances like methamphetamine or cocaine) which is productive for working or studying, but with relatively little euphoria. Similar drugs to diphenylprolinol include pipradrol, desoxypipradrol, and to a lesser extent methylphenidate.

There have been some recent indications (e.g. detailed reports posted on forums dedicated to researching this compound) that diphenyl prolinol may not be as benign as its mild effects seem to suggest. At higher doses and with more frequent administration, its effects on dopamine appear to become significant enough that binging and addiction can enter the picture. Several large overdoses requiring hospitalization have been reported, possibly related to addiction issues. It seems prudent to exercise caution when administering this compound, even for occasional work/study applications, as most dopamine reuptake inhibitors are addictive. Precautions to take might include limiting access and watching closely for symptoms of addiction, such as loss of control over dosage or difficulty stopping use once it has started.

CAS numbers: 22348-32-9 or 112068-01-6

External links

• Synthesis of diphenyl-2-pyrrolidinyl-methanol and diphenyl-2-pyrrolidinyl-methane

ar:منشطات