Daflon 500
DAFLON 500 is also distributed as: Detralex, Arvenum 500, Alvenor, Ardium, Capiven, Elatec and Venitol
DAFLON 500 abridged prescribing information
Presentation and Composition:
Micronized Purified Flavonoid Fraction 500mg: diosmin 450 mg, flavonoids expressed as hesperidin 50 mg.
Therapeutic properties:
Vascular protector and venotonic. DAFLON 500 mg acts on the return vascular system: it reduces venous distensibility and venous stasis; in the microcirculation, it normalizes capillary permeability and reinforces capillary resistance.
Pharmacokinetics:
Micronization of Daflon 500 mg increases its gastrointestinal absorption compared with nonmicronized diosmin (urinary excretion 57.9% vs 32.7%).
Therapeutic indications:
Treatment of organic and idiopathic chronic venous disease of the lower limbs with the following symptoms: heavy legs, pain, nocturnal cramps, edema. Treatment of hemorrhoids and acute hemorrhoidal attacks.
Side effects:
Some cases of minor gastrointestinal and autonomic disorders have been reported, but these never required cessation of treatment.
Drug interactions:
None
Precautions:
Pregnancy: experimental studies in animal have not demonstrated any teratogenic effects and no harmful effects have been reported in man to date. Lactation: in the absence of data concerning the diffusion into breast milk, breast-feeding is not recommended during treatment.
Contraindications:
None
Dosage and administration:
In chronic venous disease: 2 tablets daily. In hemorrhoidal disease: - Acute crisis: 6 tablets daily for 4 days, then 4 tablets daily for 3 days. - Chronic treatment: 2 tablets daily. Template:WikiDoc Sources