Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system.[3]
↑Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A, Poustka A (Oct 1997). "DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours". Nat. Genet. 17 (1): 32–9. doi:10.1038/ng0997-32. PMID9288095.
↑Rosenstiel P, Sina C, End C, Renner M, Lyer S, Till A, Hellmig S, Nikolaus S, Fölsch UR, Helmke B, Autschbach F, Schirmacher P, Kioschis P, Hafner M, Poustka A, Mollenhauer J, Schreiber S (Jun 2007). "Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion". J. Immunol. 178 (12): 8203–11. doi:10.4049/jimmunol.178.12.8203. PMID17548659.
↑Tino MJ, Wright JR (1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". Am. J. Respir. Cell Mol. Biol. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID10101009.
↑Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID9153228.
Further reading
Kang W, Reid KB (2003). "DMBT1, a regulator of mucosal homeostasis through the linking of mucosal defense and regeneration?". FEBS Lett. 540 (1–3): 21–5. doi:10.1016/S0014-5793(03)00217-5. PMID12681477.
Robbe C, Paraskeva C, Mollenhauer J, Michalski JC, Sergi C, Corfield A (2005). "DMBT1 expression and glycosylation during the adenoma-carcinoma sequence in colorectal cancer". Biochem. Soc. Trans. 33 (Pt 4): 730–2. doi:10.1042/BST0330730. PMID16042587.
Rasheed BK, McLendon RE, Friedman HS, Friedman AH, Fuchs HE, Bigner DD, Bigner SH (1995). "Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25". Oncogene. 10 (11): 2243–6. PMID7784070.
Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID9153228.
Takeshita H, Sato M, Shiwaku HO, Semba S, Sakurada A, Hoshi M, Hayashi Y, Tagawa Y, Ayabe H, Horii A (1999). "Expression of the DMBT1 gene is frequently suppressed in human lung cancer". Jpn. J. Cancer Res. 90 (9): 903–8. doi:10.1111/j.1349-7006.1999.tb00833.x. PMID10551316.
Mollenhauer J, Holmskov U, Wiemann S, Krebs I, Herbertz S, Madsen J, Kioschis P, Coy JF, Poustka A (1999). "The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instability". Oncogene. 18 (46): 6233–40. doi:10.1038/sj.onc.1203071. PMID10597221.
Prakobphol A, Xu F, Hoang VM, Larsson T, Bergstrom J, Johansson I, Frängsmyr L, Holmskov U, Leffler H, Nilsson C, Borén T, Wright JR, Strömberg N, Fisher SJ (2000). "Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340". J. Biol. Chem. 275 (51): 39860–6. doi:10.1074/jbc.M006928200. PMID11007786.
Ma JF, Takito J, Vijayakumar S, Peehl DM, Olsson CA, Al-Awqati Q (2001). "Prostatic expression of hensin, a protein implicated in epithelial terminal differentiation". Prostate. 49 (1): 9–18. doi:10.1002/pros.1113. PMID11550206.
Mollenhauer J, Herbertz S, Helmke B, Kollender G, Krebs I, Madsen J, Holmskov U, Sorger K, Schmitt L, Wiemann S, Otto HF, Gröne HJ, Poustka A (2001). "Deleted in Malignant Brain Tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer". Cancer Res. 61 (24): 8880–6. PMID11751412.
Bikker FJ, Ligtenberg AJ, van der Wal JE, van den Keijbus PA, Holmskov U, Veerman EC, Nieuw Amerongen AV (2002). "Immunohistochemical detection of salivary agglutinin/gp-340 in human parotid, submandibular, and labial salivary glands". J. Dent. Res. 81 (2): 134–9. doi:10.1177/154405910208100210. PMID11829014.
Sasaki H, Betensky RA, Cairncross JG, Louis DN (2002). "DMBT1 polymorphisms: relationship to malignant glioma tumorigenesis". Cancer Res. 62 (6): 1790–6. PMID11912156.CS1 maint: Uses authors parameter (link)
Bikker FJ, Ligtenberg AJ, Nazmi K, Veerman EC, van't Hof W, Bolscher JG, Poustka A, Nieuw Amerongen AV, Mollenhauer J (2002). "Identification of the bacteria-binding peptide domain on salivary agglutinin (gp-340/DMBT1), a member of the scavenger receptor cysteine-rich superfamily". J. Biol. Chem. 277 (35): 32109–15. doi:10.1074/jbc.M203788200. PMID12050164.
Fan X, Muñoz J, Sanko SG, Castresana JS (2002). "PTEN, DMBT1, and p16 alterations in diffusely infiltrating astrocytomas". Int. J. Oncol. 21 (3): 667–74. doi:10.3892/ijo.21.3.667. PMID12168116.
Mueller W, Mollenhauer J, Stockhammer F, Poustka A, von Deimling A (2002). "Rare mutations of the DMBT1 gene in human astrocytic gliomas". Oncogene. 21 (38): 5956–9. doi:10.1038/sj.onc.1205733. PMID12185598.
