DEK (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
The human '''''DEK''''' '''gene''' encodes the DEK [[protein]].<ref name="pmid1549122">{{cite journal | vauthors = von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G | title = The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA | journal = Mol. Cell. Biol. | volume = 12 | issue = 4 | pages = 1687–97  | date = Apr 1992 | pmid = 1549122 | pmc = 369612 | doi =  10.1128/mcb.12.4.1687}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DEK DEK oncogene (DNA binding)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7913| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_DEK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1q1v.
| PDB = {{PDB2|1q1v}}
| Name = DEK oncogene (DNA binding)
| HGNCid = 2768
| Symbol = DEK
| AltSymbols =; D6S231E
| OMIM = 125264
| ECnumber = 
| Homologene = 2593
| MGIid = 1926209
| GeneAtlas_image1 = PBB_GE_DEK_200934_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003704 |text = specific RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0042393 |text = histone binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005786 |text = signal recognition particle, endoplasmic reticulum targeting}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006614 |text = SRP-dependent cotranslational protein targeting to membrane}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0019079 |text = viral genome replication}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7913
    | Hs_Ensembl = ENSG00000124795
    | Hs_RefseqProtein = NP_003463
    | Hs_RefseqmRNA = NM_003472
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 18332392
    | Hs_GenLoc_end = 18372750
    | Hs_Uniprot = P35659
    | Mm_EntrezGene = 110052
    | Mm_Ensembl = ENSMUSG00000021377
    | Mm_RefseqmRNA = NM_025900
    | Mm_RefseqProtein = NP_080176
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 47095756
    | Mm_GenLoc_end = 47117138
    | Mm_Uniprot = Q3U4W4
  }}
}}
'''DEK oncogene (DNA binding)''', also known as '''DEK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DEK DEK oncogene (DNA binding)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7913| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein with one SAP domain. The protein binds to cruciform and superhelical [[DNA]] and induces positive supercoils into closed circular DNA. It is also involved in splice site selection during [[Messenger RNA|mRNA]] processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.<ref name="entrez">{{cite web | title = Entrez Gene: DEK DEK oncogene (DNA binding)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7913| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
''DEK'' [[Protein-protein interaction|interact]]<nowiki/>s with [[TFAP2A]].<ref name=pmid12595566>{{cite journal | vauthors = Campillos M, García MA, Valdivieso F, Vázquez J | title = Transcriptional activation by AP-2alpha is modulated by the oncogene DEK | journal = Nucleic Acids Res. | volume = 31 | issue = 5 | pages = 1571–5  | date = Mar 2003 | pmid = 12595566 | pmc = 149840 | doi = 10.1093/nar/gkg247 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = von Lindern M, Fornerod M, Soekarman N, van Baal S, Jaegle M, Hagemeijer A, Bootsma D, Grosveld G | title = Translocation t(6;9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene | journal = Baillière's Clinical Haematology | volume = 5 | issue = 4 | pages = 857–79 | year = 1992 | pmid = 1308167 | doi = 10.1016/s0950-3536(11)80049-1 }}
| citations =
* {{cite journal | vauthors = Waldmann T, Scholten I, Kappes F, Hu HG, Knippers R | title = The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin | journal = Gene | volume = 343 | issue = 1 | pages = 1–9 | year = 2004 | pmid = 15563827 | doi = 10.1016/j.gene.2004.08.029 }}
*{{cite journal | author=von Lindern M, Fornerod M, Soekarman N, ''et al.'' |title=Translocation t(6;9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene. |journal=Baillieres Clin. Haematol. |volume=5 |issue= 4 |pages= 857-79 |year= 1993 |pmid= 1308167 |doi= }}
* {{cite journal | vauthors = Denisenko ON, O'Neill B, Ostrowski J, Van Seuningen I, Bomsztyk K | title = Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein | journal = J. Biol. Chem. | volume = 271 | issue = 44 | pages = 27701–6 | year = 1996 | pmid = 8910362 | doi = 10.1074/jbc.271.44.27701 }}
*{{cite journal | author=Waldmann T, Scholten I, Kappes F, ''et al.'' |title=The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin. |journal=Gene |volume=343 |issue= 1 |pages= 1-9 |year= 2005 |pmid= 15563827 |doi= 10.1016/j.gene.2004.08.029 }}
* {{cite journal | vauthors = Fu GK, Grosveld G, Markovitz DM | title = DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 5 | pages = 1811–5 | year = 1997 | pmid = 9050861 | pmc = 19999 | doi = 10.1073/pnas.94.5.1811 }}
*{{cite journal | author=von Lindern M, Fornerod M, van Baal S, ''et al.'' |title=The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. |journal=Mol. Cell. Biol. |volume=12 |issue= 4 |pages= 1687-97 |year= 1992 |pmid= 1549122 |doi= }}
* {{cite journal | vauthors = Murray KJ, Szer W, Grom AA, Donnelly P, Levinson JE, Giannini EH, Glass DN, Szer IS | title = Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene | journal = J. Rheumatol. | volume = 24 | issue = 3 | pages = 560–7 | year = 1997 | pmid = 9058666 | doi =  }}
*{{cite journal | author=Denisenko ON, O'Neill B, Ostrowski J, ''et al.'' |title=Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein. |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27701-6 |year= 1996 |pmid= 8910362 |doi= }}
* {{cite journal | vauthors = Forero L, Zwirner NW, Fink CW, Fernández-Viña MA, Stastny P | title = Juvenile arthritis, HLA-A2 and binding of DEK oncogene-peptides | journal = Hum. Immunol. | volume = 59 | issue = 7 | pages = 443–50 | year = 1998 | pmid = 9684994 | doi = 10.1016/S0198-8859(98)00034-2 }}
*{{cite journal | author=Fu GK, Grosveld G, Markovitz DM |title=DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 5 |pages= 1811-5 |year= 1997 |pmid= 9050861 |doi=  }}
* {{cite journal | vauthors = Dong X, Michelis MA, Wang J, Bose R, DeLange T, Reeves WH | title = Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis | journal = Arthritis Rheum. | volume = 41 | issue = 8 | pages = 1505–10 | year = 1998 | pmid = 9704652 | doi = 10.1002/1529-0131(199808)41:8<1505::AID-ART23>3.0.CO;2-N }}
*{{cite journal | author=Murray KJ, Szer W, Grom AA, ''et al.'' |title=Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene. |journal=J. Rheumatol. |volume=24 |issue= 3 |pages= 560-7 |year= 1997 |pmid= 9058666 |doi= }}
* {{cite journal | vauthors = Wichmann I, Garcia-Lozano JR, Respaldiza N, Gonzalez-Escribano MF, Nuñez-Roldan A | title = Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus | journal = Hum. Immunol. | volume = 60 | issue = 1 | pages = 57–62 | year = 1999 | pmid = 9952027 | doi = 10.1016/S0198-8859(98)00085-8 }}
*{{cite journal | author=Forero L, Zwirner NW, Fink CW, ''et al.'' |title=Juvenile arthritis, HLA-A2 and binding of DEK oncogene-peptides. |journal=Hum. Immunol. |volume=59 |issue= 7 |pages= 443-50 |year= 1999 |pmid= 9684994 |doi= }}
* {{cite journal | vauthors = Alexiadis V, Waldmann T, Andersen J, Mann M, Knippers R, Gruss C | title = The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner | journal = Genes Dev. | volume = 14 | issue = 11 | pages = 1308–12 | year = 2000 | pmid = 10837023 | pmc = 316669 | doi =  }}
*{{cite journal  | author=Dong X, Michelis MA, Wang J, ''et al.'' |title=Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis. |journal=Arthritis Rheum. |volume=41 |issue= 8 |pages= 1505-10 |year= 1998 |pmid= 9704652 |doi= 10.1002/1529-0131(199808)41:8<1505::AID-ART23>3.0.CO;2-N }}
* {{cite journal | vauthors = McGarvey T, Rosonina E, McCracken S, Li Q, Arnaout R, Mientjes E, Nickerson JA, Awrey D, Greenblatt J, Grosveld G, Blencowe BJ | title = The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes | journal = J. Cell Biol. | volume = 150 | issue = 2 | pages = 309–20 | year = 2000 | pmid = 10908574 | pmc = 2180225 | doi = 10.1083/jcb.150.2.309 }}
*{{cite journal | author=Wichmann I, Garcia-Lozano JR, Respaldiza N, ''et al.'' |title=Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus. |journal=Hum. Immunol. |volume=60 |issue= 1 |pages= 57-62 |year= 1999 |pmid= 9952027 |doi=  }}
* {{cite journal | vauthors = Grottke C, Mantwill K, Dietel M, Schadendorf D, Lage H | title = Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs | journal = Int. J. Cancer | volume = 88 | issue = 4 | pages = 535–46 | year = 2000 | pmid = 11058868 | doi = 10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V }}
*{{cite journal | author=Alexiadis V, Waldmann T, Andersen J, ''et al.'' |title=The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner. |journal=Genes Dev. |volume=14 |issue= 11 |pages= 1308-12 |year= 2000 |pmid= 10837023 |doi= }}
* {{cite journal | vauthors = Le Hir H, Izaurralde E, Maquat LE, Moore MJ | title = The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions | journal = EMBO J. | volume = 19 | issue = 24 | pages = 6860–9 | year = 2000 | pmid = 11118221 | pmc = 305905 | doi = 10.1093/emboj/19.24.6860 }}
*{{cite journal | author=McGarvey T, Rosonina E, McCracken S, ''et al.'' |title=The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. |journal=J. Cell Biol. |volume=150 |issue= 2 |pages= 309-20 |year= 2000 |pmid= 10908574 |doi= }}
* {{cite journal | vauthors = Kappes F, Burger K, Baack M, Fackelmayer FO, Gruss C | title = Subcellular localization of the human proto-oncogene protein DEK | journal = J. Biol. Chem. | volume = 276 | issue = 28 | pages = 26317–23 | year = 2001 | pmid = 11333257 | doi = 10.1074/jbc.M100162200 }}
*{{cite journal  | author=Grottke C, Mantwill K, Dietel M, ''et al.'' |title=Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs. |journal=Int. J. Cancer |volume=88 |issue= 4 |pages= 535-46 |year= 2000 |pmid= 11058868 |doi= }}
* {{cite journal | vauthors = Waldmann T, Eckerich C, Baack M, Gruss C | title = The ubiquitous chromatin protein DEK alters the structure of DNA by introducing positive supercoils | journal = J. Biol. Chem. | volume = 277 | issue = 28 | pages = 24988–94 | year = 2002 | pmid = 11997399 | doi = 10.1074/jbc.M204045200 }}
*{{cite journal | author=Le Hir H, Izaurralde E, Maquat LE, Moore MJ |title=The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. |journal=EMBO J. |volume=19 |issue= 24 |pages= 6860-9 |year= 2001 |pmid= 11118221 |doi= 10.1093/emboj/19.24.6860 }}
* {{cite journal | vauthors = Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S | title = Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis | journal = Haematologica | volume = 87 | issue = 6 | pages = 569–77 | year = 2002 | pmid = 12031912 | doi = }}
*{{cite journal | author=Kappes F, Burger K, Baack M, ''et al.'' |title=Subcellular localization of the human proto-oncogene protein DEK. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26317-23 |year= 2001 |pmid= 11333257 |doi= 10.1074/jbc.M100162200 }}
* {{cite journal | vauthors = Hollenbach AD, McPherson CJ, Mientjes EJ, Iyengar R, Grosveld G | title = Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek | journal = J. Cell Sci. | volume = 115 | issue = Pt 16 | pages = 3319–30 | year = 2002 | pmid = 12140263 | doi =  }}
*{{cite journal | author=Waldmann T, Eckerich C, Baack M, Gruss C |title=The ubiquitous chromatin protein DEK alters the structure of DNA by introducing positive supercoils. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 24988-94 |year= 2002 |pmid= 11997399 |doi= 10.1074/jbc.M204045200 }}
* {{cite journal | vauthors = Krithivas A, Fujimuro M, Weidner M, Young DB, Hayward SD | title = Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes | journal = J. Virol. | volume = 76 | issue = 22 | pages = 11596–604 | year = 2002 | pmid = 12388720 | pmc = 136775 | doi = 10.1128/JVI.76.22.11596-11604.2002 }}
*{{cite journal | author=Larramendy ML, Niini T, Elonen E, ''et al.'' |title=Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis. |journal=Haematologica |volume=87 |issue= 6 |pages= 569-77 |year= 2003 |pmid= 12031912 |doi=  }}
*{{cite journal | author=Hollenbach AD, McPherson CJ, Mientjes EJ, ''et al.'' |title=Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. |journal=J. Cell. Sci. |volume=115 |issue= Pt 16 |pages= 3319-30 |year= 2003 |pmid= 12140263 |doi= }}
*{{cite journal  | author=Krithivas A, Fujimuro M, Weidner M, ''et al.'' |title=Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes. |journal=J. Virol. |volume=76 |issue= 22 |pages= 11596-604 |year= 2002 |pmid= 12388720 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=7913}}
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[[Category:Oncogenes]]

Latest revision as of 17:42, 5 December 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

The human DEK gene encodes the DEK protein.[1][2]

Function

This gene encodes a protein with one SAP domain. The protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA. It is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.[2]

Interactions

DEK interacts with TFAP2A.[3]

References

  1. ↑ von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G (Apr 1992). "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA". Mol. Cell. Biol. 12 (4): 1687–97. doi:10.1128/mcb.12.4.1687. PMC 369612. PMID 1549122.
  2. ↑ 2.0 2.1 "Entrez Gene: DEK DEK oncogene (DNA binding)".
  3. ↑ Campillos M, García MA, Valdivieso F, Vázquez J (Mar 2003). "Transcriptional activation by AP-2alpha is modulated by the oncogene DEK". Nucleic Acids Res. 31 (5): 1571–5. doi:10.1093/nar/gkg247. PMC 149840. PMID 12595566.

Further reading


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