DDX17: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Probable ATP-dependent RNA helicase DDX17 (p72)''' is an [[enzyme]] that in humans is encoded by the ''DDX17'' [[gene]].<ref name="pmid8871553">{{cite journal | vauthors = Lamm GM, Nicol SM, Fuller-Pace FV, Lamond AI | title = p72: a human nuclear DEAD box protein highly related to p68 | journal = Nucleic Acids Res | volume = 24 | issue = 19 | pages = 3739–47 | date = Dec 1996 | pmid = 8871553 | pmc = 146168 | doi = 10.1093/nar/24.19.3739 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10521| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
| HGNCid = 2740
| Symbol = DDX17
| AltSymbols =; DKFZp761H2016; P72; RH70
| OMIM = 608469
| ECnumber = 
| Homologene = 6797
| MGIid = 1914290
| GeneAtlas_image1 = PBB_GE_DDX17_208151_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_DDX17_208718_at_tn.png
| GeneAtlas_image3 = PBB_GE_DDX17_208719_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003724 |text = RNA helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0008186 |text = RNA-dependent ATPase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006396 |text = RNA processing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10521
    | Hs_Ensembl = ENSG00000100201
    | Hs_RefseqProtein = NP_006377
    | Hs_RefseqmRNA = NM_006386
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 37209389
    | Hs_GenLoc_end = 37232262
    | Hs_Uniprot = Q92841
    | Mm_EntrezGene = 67040
    | Mm_Ensembl = ENSMUSG00000055065
    | Mm_RefseqmRNA = NM_001040187
    | Mm_RefseqProtein = NP_001035277
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 79354997
    | Mm_GenLoc_end = 79373996
    | Mm_Uniprot = Q3TU25
  }}
}}
'''DEAD (Asp-Glu-Ala-Asp) box polypeptide 17''', also known as '''DDX17''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10521| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and [[spliceosome]] assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species but not by dsDNA. This protein and that encoded by DDX5 gene are more closely related to each other than to any other member of the DEAD box family. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms with the longer transcript reported to also initiate translation at a non-AUG (CUG) start site.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and [[spliceosome]] assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species but not by dsDNA. This protein and that encoded by DDX5 gene are more closely related to each other than to any other member of the DEAD box family. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms with the longer transcript reported to also initiate translation at a non-AUG (CUG) start site.<ref name="entrez">{{cite web | title = Entrez Gene: DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10521| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
DDX17 has been shown to [[Protein-protein interaction|interact]] with:
* [[DDX5 | DDX5 (p68)]],<ref name = pmid12595555>{{cite journal | vauthors = Ogilvie VC, Wilson BJ, Nicol SM, Morrice NA, Saunders LR, Barber GN, Fuller-Pace FV | title = The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells | journal = Nucleic Acids Res. | volume = 31 | issue = 5 | pages = 1470–80 | pmid = 12595555 | pmc = 149829 | doi =  10.1093/nar/gkg236}}</ref>
* [[DHX9 | DHX9 (RNA Helicase A)]],<ref name = pmid18005418>{{cite journal | vauthors = Wilson BJ, Giguère V | title = Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis | journal = BMC Genomics | volume = 8 | issue =  | pages = 419 | date = Nov 2007 | pmid = 18005418 | pmc = 3225811 | doi = 10.1186/1471-2164-8-419 }}</ref>
* [[HDAC1]],<ref name = pmid15298701>{{cite journal | vauthors = Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV | title = The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner | journal = BMC Mol. Biol. | volume = 5 | issue =  | pages = 11 | date = Aug 2004 | pmid = 15298701 | pmc = 514542 | doi = 10.1186/1471-2199-5-11 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lüking A, Stahl U, Schmidt U | title = The protein family of RNA helicases | journal = Crit. Rev. Biochem. Mol. Biol. | volume = 33 | issue = 4 | pages = 259–96 | year = 1998 | pmid = 9747670 | doi = 10.1080/10409239891204233 }}
| citations =
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Lüking A, Stahl U, Schmidt U |title=The protein family of RNA helicases. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=33 |issue= 4 |pages= 259-96 |year= 1998 |pmid= 9747670 |doi= }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-Scale Concatenation cDNA Sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | year = 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
*{{cite journal | author=Lamm GM, Nicol SM, Fuller-Pace FV, Lamond AI |title=p72: a human nuclear DEAD box protein highly related to p68. |journal=Nucleic Acids Res. |volume=24 |issue= 19 |pages= 3739-47 |year= 1996 |pmid= 8871553 |doi=  }}
* {{cite journal | vauthors = Uhlmann-Schiffler H, Rössler OG, Stahl H | title = The mRNA of DEAD box protein p72 is alternatively translated into an 82-kDa RNA helicase | journal = J. Biol. Chem. | volume = 277 | issue = 2 | pages = 1066–75 | year = 2002 | pmid = 11675387 | doi = 10.1074/jbc.M107535200 }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Hönig A, Auboeuf D, Parker MM, O'Malley BW, Berget SM | title = Regulation of Alternative Splicing by the ATP-Dependent DEAD-Box RNA Helicase p72 | journal = Mol. Cell. Biol. | volume = 22 | issue = 16 | pages = 5698–707 | year = 2002 | pmid = 12138182 | pmc = 133985 | doi = 10.1128/MCB.22.16.5698-5707.2002 }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
* {{cite journal | vauthors = Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T | title = A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 40362–7 | year = 2002 | pmid = 12171929 | doi = 10.1074/jbc.M206194200 }}
*{{cite journal | author=Watanabe M, Yanagisawa J, Kitagawa H, ''et al.'' |title=A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. |journal=EMBO J. |volume=20 |issue= 6 |pages= 1341-52 |year= 2001 |pmid= 11250900 |doi= 10.1093/emboj/20.6.1341 }}
* {{cite journal | vauthors = Lee CG | title = RH70, a bidirectional RNA helicase, co-purifies with U1snRNP | journal = J. Biol. Chem. | volume = 277 | issue = 42 | pages = 39679–83 | year = 2002 | pmid = 12193588 | doi = 10.1074/jbc.C200337200 }}
*{{cite journal  | author=Uhlmann-Schiffler H, Rössler OG, Stahl H |title=The mRNA of DEAD box protein p72 is alternatively translated into an 82-kDa RNA helicase. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1066-75 |year= 2002 |pmid= 11675387 |doi= 10.1074/jbc.M107535200 }}
* {{cite journal | vauthors = Ogilvie VC, Wilson BJ, Nicol SM, Morrice NA, Saunders LR, Barber GN, Fuller-Pace FV | title = The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells | journal = Nucleic Acids Res. | volume = 31 | issue = 5 | pages = 1470–80 | year = 2003 | pmid = 12595555 | pmc = 149829 | doi = 10.1093/nar/gkg236 }}
*{{cite journal | author=Hönig A, Auboeuf D, Parker MM, ''et al.'' |title=Regulation of alternative splicing by the ATP-dependent DEAD-box RNA helicase p72. |journal=Mol. Cell. Biol. |volume=22 |issue= 16 |pages= 5698-707 |year= 2002 |pmid= 12138182 |doi= }}
* {{cite journal | vauthors = Fujita T, Kobayashi Y, Wada O, Tateishi Y, Kitada L, Yamamoto Y, Takashima H, Murayama A, Yano T, Baba T, Kato S, Kawabe Y, Yanagisawa J | title = Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells | journal = J. Biol. Chem. | volume = 278 | issue = 29 | pages = 26704–14 | year = 2003 | pmid = 12738788 | doi = 10.1074/jbc.M301031200 }}
*{{cite journal | author=Ohta S, Shiomi Y, Sugimoto K, ''et al.'' |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362-7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200 }}
* {{cite journal | vauthors = Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG | title = Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins | journal = Mol. Cell. Biol. | volume = 23 | issue = 21 | pages = 7437–47 | year = 2003 | pmid = 14559993 | pmc = 207616 | doi = 10.1128/MCB.23.21.7437-7447.2003 }}
*{{cite journal | author=Lee CG |title=RH70, a bidirectional RNA helicase, co-purifies with U1snRNP. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39679-83 |year= 2002 |pmid= 12193588 |doi= 10.1074/jbc.C200337200 }}
* {{cite journal | vauthors = Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV | title = The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner | journal = BMC Mol. Biol. | volume = 5 | pages = 11 | year = 2005 | pmid = 15298701 | pmc = 514542 | doi = 10.1186/1471-2199-5-11 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Curr. Biol. | volume = 14 | issue = 16 | pages = 1436–50 | year = 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | author=Ogilvie VC, Wilson BJ, Nicol SM, ''et al.'' |title=The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells. |journal=Nucleic Acids Res. |volume=31 |issue= 5 |pages= 1470-80 |year= 2003 |pmid= 12595555 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions | journal = Genome Res. | volume = 14 | issue = 9 | pages = 1711–8 | year = 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal | author=Fujita T, Kobayashi Y, Wada O, ''et al.'' |title=Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26704-14 |year= 2003 |pmid= 12738788 |doi= 10.1074/jbc.M301031200 }}
* {{cite journal | vauthors = Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I | title = A genome annotation-driven approach to cloning the human ORFeome | journal = Genome Biol. | volume = 5 | issue = 10 | pages = R84 | year = 2005 | pmid = 15461802 | pmc = 545604 | doi = 10.1186/gb-2004-5-10-r84 }}
*{{cite journal | author=Li J, Hawkins IC, Harvey CD, ''et al.'' |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437-47 |year= 2003 |pmid= 14559993 |doi= }}
*{{cite journal | author=Wilson BJ, Bates GJ, Nicol SM, ''et al.'' |title=The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. |journal=BMC Mol. Biol. |volume=5 |issue=  |pages= 11 |year= 2005 |pmid= 15298701 |doi= 10.1186/1471-2199-5-11 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}
[[Category:Spliceosome]]


{{gene-22-stub}}
{{gene-22-stub}}
{{WikiDoc Sources}}

Latest revision as of 18:18, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable ATP-dependent RNA helicase DDX17 (p72) is an enzyme that in humans is encoded by the DDX17 gene.[1][2]

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species but not by dsDNA. This protein and that encoded by DDX5 gene are more closely related to each other than to any other member of the DEAD box family. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms with the longer transcript reported to also initiate translation at a non-AUG (CUG) start site.[2]

Interactions

DDX17 has been shown to interact with:

References

  1. ↑ Lamm GM, Nicol SM, Fuller-Pace FV, Lamond AI (Dec 1996). "p72: a human nuclear DEAD box protein highly related to p68". Nucleic Acids Res. 24 (19): 3739–47. doi:10.1093/nar/24.19.3739. PMC 146168. PMID 8871553.
  2. ↑ 2.0 2.1 "Entrez Gene: DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17".
  3. ↑ Ogilvie VC, Wilson BJ, Nicol SM, Morrice NA, Saunders LR, Barber GN, Fuller-Pace FV. "The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells". Nucleic Acids Res. 31 (5): 1470–80. doi:10.1093/nar/gkg236. PMC 149829. PMID 12595555.
  4. ↑ Wilson BJ, Giguère V (Nov 2007). "Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis". BMC Genomics. 8: 419. doi:10.1186/1471-2164-8-419. PMC 3225811. PMID 18005418.
  5. ↑ Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV (Aug 2004). "The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner". BMC Mol. Biol. 5: 11. doi:10.1186/1471-2199-5-11. PMC 514542. PMID 15298701.

Further reading


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