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Revision as of 18:55, 21 October 2012

Cystic medial necrosis
ICD-9 441.00
OMIM 607086
DiseasesDB 30073

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: cystic medial degeneration; Familial thoracic aortic aneurysm (also referred to as familial aortic dissection or cystic medial necrosis of aorta)[1]

Overview

Cystic medial necrosis is a disorder of large arteries. A degenerative breakdown of collagen, elastin, and smooth muscle caused by aging contribute to weakening of the wall of the artery.[2]

In the aorta,this can result in the formation of a fusiform aneurysm. There is also increased risk of aortic dissection.

There is an association between cystic medial necrosis and Marfan syndrome.

Terminology

It is sometimes called "Erdheim's cystic medial necrosis", after Jakob Erdheim.[3][4]

The term "cystic medial degeneration" is sometimes used instead of "cystic medial necrosis", because necrosis is not always found. However, the findings are not always cystic either, making the terminology complex.

References

  1. Online Mendelian Inheritance in Man (OMIM) 607086
  2. Wiesenfarth, John, http://www.emedicine.com/emerg/topic28.htm, October 4, 2005
  3. Template:WhoNamedIt
  4. J. Erdheim. Medionecrosis aortae idiopathica (cystica). Archiv für pathologische Anatomie und Physiologie und für klinische Medizin, 1929, 273: 454-479.

See also

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