Creutzfeldt-Jakob disease causes: Difference between revisions
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{{Creutzfeldt-Jakob disease}} | {{Creutzfeldt-Jakob disease}} | ||
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==Overview== | |||
Creutzfeldt-Jakob disease is caused by the presence of a [[prion]] [[protein]], an abnormal isoform of a [[cellular]] [[glycoprotein]]. [[Prion]]s are transmissible particles that are devoid of [[nucleic acid]] and seem to be composed exclusively of a modified protein (PrPSc). The normal, [[cellular]] PrP ([[PrPC]]) is converted into [[PrPSc]] through a posttranslational process during which it acquires a high beta-sheet content. | |||
==Causes== | ==Causes== | ||
*Creutzfeldt-Jakob disease is caused by the presence of a [[prion]] [[protein]], an abnormal isoform of a [[cellular]] [[glycoprotein]].<ref name="www.cdc.gov">{{Cite web | last = | first = | title = http://www.cdc.gov/ncidod/dvrd/cjd/qa_cjd_infection_control.htm#what | url = http://www.cdc.gov/ncidod/dvrd/cjd/qa_cjd_infection_control.htm#what | publisher = | date = | accessdate = 14 February 2014 }}</ref> | |||
*[[Prion]]s are transmissible particles that are devoid of [[nucleic acid]] and seem to be composed exclusively of a modified protein ([[PrPSc]]). The normal, cellular PrP ([[PrPC]]) is converted into [[PrPSc]] through a posttranslational process during which it acquires a high beta-sheet content.<ref name="pmid9811807">{{cite journal| author=Prusiner SB| title=Prions. | journal=Proc Natl Acad Sci U S A | year= 1998 | volume= 95 | issue= 23 | pages= 13363-83 | pmid=9811807 | doi= | pmc=33918 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9811807 }} </ref> | |||
==References== | ==References== | ||
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[[Category:Neurology]] | [[Category:Neurology]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Latest revision as of 19:46, 7 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: , Mohamadmostafa Jahansouz M.D.[2]
Overview
Creutzfeldt-Jakob disease is caused by the presence of a prion protein, an abnormal isoform of a cellular glycoprotein. Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of a modified protein (PrPSc). The normal, cellular PrP (PrPC) is converted into PrPSc through a posttranslational process during which it acquires a high beta-sheet content.
Causes
- Creutzfeldt-Jakob disease is caused by the presence of a prion protein, an abnormal isoform of a cellular glycoprotein.[1]
- Prions are transmissible particles that are devoid of nucleic acid and seem to be composed exclusively of a modified protein (PrPSc). The normal, cellular PrP (PrPC) is converted into PrPSc through a posttranslational process during which it acquires a high beta-sheet content.[2]