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| {{drugbox | | __NOTOC__ |
| | IUPAC_name = 1-[(2-chlorophenyl)-diphenyl-methyl]imidazole
| | {{Clotrimazole}} |
| | image = Clotrimazole structure.svg
| | {{CMG}} {{AE}} {{AZ}} |
| | image2 = Clotrimazole-3D-balls.png
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| | width=200
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| | CAS_number = 23593-75-1
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| | ATC_prefix = A01
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| | ATC_suffix = AB18
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| | ATC_supplemental = {{ATC|D01|AC01}}, {{ATC|G01|AF02}}
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| | PubChem = 2812
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| | DrugBank = APRD00244
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| | C=22 | H=17 | Cl=1 | N=2
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| | molecular_weight = 344.837 g/mol
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| | bioavailability = Poorly and erratically absorbed orally
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| | protein_bound = 90%
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| | metabolism = [[hepatic]]
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| | elimination_half-life = 2 hours
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| | pregnancy_AU = A
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| | pregnancy_category = C (oral) & B (topical) <small>([[United States|US]])</small>
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| | legal_AU =
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| | legal_UK = P
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| | legal_US =
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| | legal_status =
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| | routes_of_administration = [[topical]]
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| }} | |
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| '''Clotrimazole''' is an [[antifungal]] medication commonly used in the treatment of fungal infections of both humans and animals such as [[candidiasis|vaginal yeast infections]] and [[ringworm]]. It is also used to treat [[athlete's foot]] and [[jock itch]].
| | ==Overview== |
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| ==Indications and formulations== | | ==Category== |
| It is commonly available as an [[over-the-counter substance]] in various [[Effective dose|dosage]] forms, such as a cream, and also (especially in the case of [[otitis externa|ear infection]]) as a combination medicine. In the latter case, it typically includes an antibiotic such as [[Marbofloxacin]], and is applied in liquid form, as ear drops.
| | Antifungal |
| | ==US Brand Names== |
| | ClotrimazOil <sup>®</sup> ,AARDORA<sup>®</sup> |
| | ==FDA Package Insert== |
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| Fungal infections can be slow to clear up, so the usual course for an anti-fungal agent is generally longer than the typical 3-7 days of an [[antibiotic]].
| | ''' [[Clotrimazole description|Description]]''' |
| | '''| [[Clotrimazole clinical pharmacology|Clinical Pharmacology]]''' |
| | '''| [[Clotrimazole microbiology|Microbiology]]''' |
| | '''| [[Clotrimazole indications and usage|Indications and Usage]]''' |
| | '''| [[Clotrimazole contraindications|Contraindications]]''' |
| | '''| [[Clotrimazole warnings and precautions|Warnings and Precautions]]''' |
| | '''| [[Clotrimazole adverse reactions|Adverse Reactions]]''' |
| | '''| [[Clotrimazole drug interactions|Drug Interactions]]''' |
| | '''| [[Clotrimazole overdosage|Overdosage]]''' |
| | '''| [[Clotrimazole clinical studies|Clinical Studies]]''' |
| | '''| [[Clotrimazole dosage and administration|Dosage and Administration]]''' |
| | '''| [[Clotrimazole how supplied|How Supplied]]''' |
| | '''| [[Clotrimazole labels and packages|Labels and Packages]]''' |
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| Women who suffer from vaginal yeast infections, such as [[candidiasis]], can buy clotrimazole at a [[pharmacy]].
| | ==Mechanism of Action== |
| In the UK, Australia, Canada, Germany, and parts of Latin America and the Caribbean the drug is marketed under the name Canesten. In the US it is marketed as MyCelex and Lotrimin or Lotrimin AF; in Israel, as Agisten, Clotrimaderm, or Clotrimazole-Teva.
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| In Australia suffers can use 'Clonea Antifungal Skin Cream' which contains 10mg/g of clotrimazole, and should be applied sparingly to the affected area 2-3 times daily. Furthermore it is essential to continue using the cream two weeks after the infection is disappeared to avoid reinfection.
| | ==References== |
| | {{Reflist|2}} |
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| [[Image:DSC000881.JPG|right|thumb|Clotrimazole 2% cream in U.K.]]
| | [[Category:Antibiotics]] |
| [[Image:DSC000884.JPG|right|thumb|Clotrimazole 1% powder in U.K.]]
| | [[Category:Wikinfect]] |
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| ==Drug interactions==
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| There is the potential for [[drug interaction]]s with Clotrimazole if taken orally, as it is a potent, specific [[Enzyme inhibitor|inhibitor]] of [[cytochrome P450 oxidase]] [[enzyme]]s and so may alter the [[drug metabolism|metabolism]] of other drugs.
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| ==Side effects==
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| Occasionally may cause localised irritation of the skin with a mild burning sensation, redness and itching.
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| ==External links==
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| * [http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682753.html MedlinePlus] - Clotrimazole
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| {{Stomatological preparations}}
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| {{Antifungals}}
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| {{Gynecological anti-infectives and antiseptics}}
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| [[Category:Antifungals]] | |
| [[Category:Imidazoles]] | |
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| {{antimicrobial-stub}}
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| {{Link FA|de}}
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| [[de:Clotrimazol]]
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| [[hu:Klotrimazol]]
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| [[pl:Klotrimazol]]
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| [[ru:Клотримазол]]
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| [[sv:Klotrimazol]]
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