Chronic myelogenous leukemia other diagnostic studies
Reverse transcriptase (RT) PCR
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Other diagnostic studies for chronic myelogenous leukemia include bone marrow aspiration and biopsy, lumbar puncture, and lymph node biopsy. Genomic PCR, Southern blot assay, Reverse transcriptase (RT) PCR, Northern blot analysis, Western blot analysis or immunoprecipitation can be helpful in the diagnosis of chronic myelogenous leukemia; the gold standard diagnostic test in chronic myelogenous leukemia is cytogenetic analysis.[1][2][3]
Other diagnostic studies
Other diagnostic studies for chronic myelogenous leukemia include:[1][2][3]
- Used to detect and/or determine the type of leukemic cells
- Used to detect any metastasis to the cerebral spinal fluid (CSF)
- Lymph node biopsy
- Used to detect and/or determine the type of leukemic cells
- Genomic PCR
- can determine the exact breakpoints of the fusion genes
- Southern blot assay
- can determine the exact breakpoints of the fusion genes
- Reverse transcriptase (RT) PCR
- detect BCR-ABL transcripts at the RNA level
- Northern blot analysis
- detect BCR-ABL transcripts at the RNA level
- Western blot analysis
- demonstrate the p210bcr-abl protein by using monoclonal antibodies against Bcr and Abl
- Immunoprecipitation
- demonstrate the p210bcr-abl protein by using monoclonal antibodies against Bcr and Abl
Gallery
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![Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]](/images/e/e4/CDR554337-274.jpg)
Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]
![Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope.[4]](/index.php/File:CDR554337-274.jpg)
References
- ↑ 1.0 1.1 Faderl S, Talpaz M, Estrov Z, Kantarjian HM (August 1999). "Chronic myelogenous leukemia: biology and therapy". Ann. Intern. Med. 131 (3): 207–19. PMID 10428738.
- ↑ 2.0 2.1 von Bubnoff N, Duyster J (February 2010). "Chronic myelogenous leukemia: treatment and monitoring". Dtsch Arztebl Int. 107 (7): 114–21. doi:10.3238/arztebl.2010.0114. PMC 2835925. PMID 20221270.
- ↑ 3.0 3.1 Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/types/leukemia/patient/cml-treatment-pdq