|
|
| Line 1: |
Line 1: |
| '''For patient information click [[Leukemia (patient information)|here]]''' | | '''For patient information click [[Leukemia (patient information)|here]]''' |
| | |
| {{DiseaseDisorder infobox | | | {{DiseaseDisorder infobox | |
| Name = Chronic myelogenous leukemia | | | Name = Chronic myelogenous leukemia | |
| Line 10: |
Line 11: |
| OMIM_mult = | | | OMIM_mult = | |
| MedlinePlus = 000570 | | | MedlinePlus = 000570 | |
| eMedicineSubj = med | | | eMedicineSubj = | |
| eMedicineTopic = 371 | | | eMedicineTopic = | |
| DiseasesDB = 2659 | | | DiseasesDB = 2659 | |
| }} | | }} |
| {{SI}} | | {{Chronic myelogenous leukemia}} |
| {{CMG}} | | {{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}} |
| | |
| '''Associate Editor-In-Chief:''' {{CZ}} | |
| | |
| {{Editor Help}}
| |
|
| |
|
| ==Overview== | | ==[[Chronic myelogenous leukemia overview|Overview]]== |
| '''Chronic myelogenous leukemia''' ('''CML''') is a form of [[leukemia]] characterized by the increased and unregulated growth of predominantly [[myeloid]] cells in the [[bone marrow]] and the accumulation of these cells in the blood. CML is a clonal bone marrow [[stem cell]] disorder in which proliferation of mature [[granulocyte]]s ([[neutrophil]]s, [[eosinophil]]s, and [[basophil]]s) and their precursors is the main finding. It is a type of [[myeloproliferative disease]] associated with a characteristic [[chromosomal translocation]] called the [[Philadelphia chromosome]]. Historically, it has been treated with [[chemotherapy]], [[interferon]] and [[bone marrow transplantation]], although [[targeted therapy|targeted therapies]] introduced at the beginning of the 21st century have radically changed the management of CML.
| |
|
| |
|
| ==Epidemiology== | | ==[[Chronic myelogenous leukemia classification|Classification]]== |
| | [[Chronic myelogenous leukemia classification#Chronic phase|Chronic phase]] | [[Chronic myelogenous leukemia classification#Accelerated phaseAccelerated phase]] | [[Chronic myelogenous leukemia classification#Blast crisis|Blast crisis]] |
|
| |
|
| CML occurs in all age groups, but most commonly in the middle-aged and elderly. Its annual [[incidence (epidemiology)|incidence]] is 1–2 per 100,000 people, and slightly more men than women are affected. CML represents about 15–20% of all cases of adult leukemia in Western populations.<ref name="Faderl1990">{{cite journal|title=Chronic myelogenous leukemia: biology and therapy.|author=Faderl S, Talpaz M, Estrov Z, Kantarjian HM|journal=Annals of Internal Medicine|date=1999|volume=131|issue=3|pages=207-219|pmid=10428738}}</ref> The only well-described risk factor for CML is exposure to [[ionizing radiation]]; for example, increased rates of CML were seen in people exposed to the atomic bombings of Hiroshima and Nagasaki.<ref>{{cite journal|title=Radiogenic leukemia revisited|author=Moloney WC|date=1987|journal=Blood|volume=70|issue=4|pages=905-908|pmid=3477299}}</ref>
| | ==[[Chronic myelogenous leukemia historical perspective|Historical Perspective]]== |
|
| |
|
| ==Signs and symptoms== | | ==[[Chronic myelogenous leukemia pathophysiology|Pathophysiology]]== |
|
| |
|
| Patients are often [[asymptomatic]] at diagnosis, presenting incidentally with an elevated [[white blood cell]] count on a routine laboratory test. In this setting, CML must be distinguished from a [[leukemoid reaction]], which can have a similar appearance on a [[blood film|blood smear]]. Symptoms of CML may include: [[malaise]], [[low-grade fever]], [[gout]], increased susceptibility to [[infection]]s, [[anemia]], and [[thrombocytopenia]] with easy [[bruising]] (although an ''increased'' [[platelet]] count ([[thrombocytosis]]) may also occur in CML). [[Splenomegaly]] may also be seen.<ref name="Faderl1990"/><ref name="Tefferi">{{cite journal|title=Classification, diagnosis and management of myeloproliferative disorders in the JAK2V617F era|author=Tefferi A|journal=Hematology Am Soc Hematol Educ Program|date=2006|pages=240-245|pmid=17124067}}</ref>
| | ==[[Chronic myelogenous leukemia epidemiology and demographics|Epidemiology & Demographics]]== |
|
| |
|
| ==Pathophysiology== | | ==[[Chronic myelogenous leukemia risk factors|Risk Factors]]== |
|
| |
|
| CML was the first malignancy to be linked to a clear genetic abnormality, the [[chromosomal translocation]] known as the [[Philadelphia chromosome]]. This chromosomal abnormality is so named because it was first discovered and described in 1960 by two scientists from Philadelphia, Pennsylvania: Peter Nowell of the University of Pennsylvania and David Hungerford of the [[Fox Chase Cancer Center]]. <ref>{{cite journal|title=Discovery of the Philadelphia chromosome: a personal perspective|author=Nowell PC|date=2007|journal=Journal of Clinical Investigation|volume=117|issue=8|pages=2033-2035|pmid=17671636}}</ref>
| | ==[[Chronic myelogenous leukemia screening|Screening]]== |
|
| |
|
| In this translocation, parts of two chromosomes (the 9<sup>th</sup> and 22<sup>nd</sup> by conventional [[karyotype|karyotypic]] numbering) switch places. As a result, part of the BCR ("breakpoint cluster region") gene from chromosome 22 is fused with the ABL gene on chromosome 9. This abnormal "fusion" gene generates a protein of p210 or sometimes p185 weight (p is a weight measure of cellular proteins in kDa). Because abl carries a domain that can add phosphate groups to tyrosine residues (a [[tyrosine kinase]]), the bcr-abl fusion gene product is also a tyrosine kinase.<ref name="Faderl1990"/><ref name="Hehlmann">{{cite journal|title=Chronic myeloid leukaemia|author=Hehlmann R, Hochhaus A, Baccarani M; European LeukemiaNet|journal=Lancet|volume=370|issue=9584|pages=342-50|date=2007|pmid=17662883}}</ref>
| | ==[[Chronic myelogenous leukemia causes|Causes]]== |
|
| |
|
| The fused bcr-abl protein interacts with the interleukin 3beta(c) receptor subunit. The bcr-abl transcript is continuously active and does not require activation by other cellular messaging proteins. In turn, bcr-abl activates a cascade of proteins which control the [[cell cycle]], speeding up cell division. Moreover, the bcr-abl protein inhibits DNA repair, causing genomic instability and making the cell more susceptible to developing further genetic abnormalities. The action of the bcr-abl protein is the pathophysiologic cause of chronic myelogenous leukemia. With improved understanding of the nature of the bcr-abl protein and its action as a tyrosine kinase, [[targeted therapy|targeted therapies]] have been developed (the first of which was [[imatinib mesylate]]) which specifically inhibit the activity of the bcr-abl protein. These tyrosine kinase inhibitors can induce complete remissions in CML, confirming the central importance of bcr-abl as the cause of CML.<ref name="Hehlmann"/>
| | ==[[Chronic myelogenous leukemia differential diagnosis|Differentiating Chronic myelogenous leukemia from other Diseases]]== |
|
| |
|
| [[Image:CDR526538-571.jpg|600px|center|thumb|Blood cell development. A blood stem cell goes through several steps to become a [[red blood cell]], [[platelet]], or [[white blood cell]]. [http://www.cancer.gov/cancertopics/pdq/treatment/CML/patient/ Source].]] | | ==[[Chronic myelogenous leukemia natural history|Natural History, Complications & Prognosis]]== |
|
| |
|
| ==Diagnosis== | | ==Diagnosis== |
| CML is often suspected on the basis on the [[complete blood count]], which shows increased [[granulocyte]]s of all types, typically including immature myeloid cells. [[Basophil]]s and [[eosinophil]]s are almost universally increased; this feature may help differentiate CML from a [[leukemoid reaction]]. A [[bone marrow biopsy]] is often performed as part of the evaluation for CML, but bone marrow morphology alone is insufficient to diagnose CML.<ref name="Hehlmann"/><ref name="Tefferi"/>
| | [[Chronic myelogenous leukemia history and symptoms|History & Symptoms]] | [[Chronic myelogenous leukemia physical examination|Physical Examination]] | [[Chronic myelogenous leukemia staging|Staging]] | [[Chronic myelogenous leukemia laboratory tests|Lab Tests]] | [[Chronic myelogenous leukemia electrocardiogram|Electrocardiogram]] | [[Chronic myelogenous leukemia chest x ray|Chest X Ray]] | [[Chronic myelogenous leukemia CT|CT]] | [[Chronic myelogenous leukemia MRI|MRI]] | [[Chronic myelogenous leukemia echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Chronic myelogenous leukemia other imaging findings|Other Imaging Findings]] | [[Chronic myelogenous leukemia other diagnostic studies#Biopsy|Biopsy]] | [[Chronic myelogenous leukemia other diagnostic studies#Philadelphia chromosome|Philadelphia chromosome]] |
| | |
| [[Image:CDR554337-274.jpg|center|thumb|450px|Bone marrow aspiration and biopsy. After a small area of skin is numbed, a Jamshidi needle (a long, hollow needle) is inserted into the patient’s hip bone. Samples of blood, bone, and bone marrow are removed for examination under a microscope. [http://www.cancer.gov/cancertopics/pdq/treatment/CML/patient/ Source]]] | |
| | |
| Ultimately, CML is diagnosed by detecting the [[Philadelphia chromosome]]. This characteristic chromosomal abnormality can be detected by routine [[cytogenetics]], by [[fluorescent in situ hybridization]], or by [[PCR]] for the bcr-abl fusion gene.<ref name="Tefferi"/>
| |
| | |
| [[Image:CDR533336-571.jpg|thumb|center|450px|[[Philadelphia chromosome]]. A piece of chromosome 9 and a piece of chromosome 22 break off and trade places. The bcr-abl gene is formed on chromosome 22 where the piece of chromosome 9 attaches. The changed chromosome 22 is called the [[Philadelphia chromosome]] [http://www.cancer.gov/cancertopics/pdq/treatment/CML/patient/ Source].]]
| |
| | |
| Controversy exists over so-called ''Ph-negative'' CML, or cases of suspected CML in which the Philadelphia chromosome cannot be detected. Many such patients in fact have complex chromosomal abnormalities which mask the (9;22) translocation, or have evidence of the translocation by [[fluorescent in situ hybridization|FISH]] or [[RT-PCR]] in spite of normal routine karyotyping.<ref>{{cite journal|title=Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period|author=Savage DG; Szydlo RM; Goldman JM|journal=Br J Haematol|date=1997|volume=96|issue=1|pages=111-116|pmid=9012696}}</ref> The small subset of patients without detectable molecular evidence of bcr-abl fusion may be better classified as having an undifferentiated myelodysplastic/myeloproliferative disorder, as their clinical course tends to be different from patients with CML.<ref name="WHO">{{cite journal|title=Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert pane|author=Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA, Barosi G, Verstovsek S, Birgegard G, Mesa R, Reilly JT, Gisslinger H, Vannucchi AM, Cervantes F, Finazzi G, Hoffman R, Gilliland DG, Bloomfield CD, Vardiman JW|date=2007|journal=Blood|volume=110|issue=4|pages=1092-1097|pmid=17488875}}</ref>
| |
| | |
| | |
| <div align="left">
| |
| <gallery heights="175" widths="175">
| |
| Image:CML 0001.jpg|Chronic myelogenous leukemia
| |
| Image:CML 0002.jpg|Chronic myelogenous leukemia
| |
| Image:CMMoL 0001.jpg|Chronic myelomonocytic leukemia ( CMMoL)
| |
| </gallery>
| |
| </div>
| |
| | |
| ==Phases of CML==
| |
| | |
| CML is often divided into three phases based on clinical characteristics and laboratory findings. In the absence of intervention, CML typically begins in the ''chronic'' phase, and over the course of several years progresses to an ''accelerated'' phase and ultimately to a ''blast crisis''. Blast crisis is the terminal phase of CML and clinically behaves like an [[acute leukemia]]. One of the drivers of the progression from chronic phase through acceleration and blast crisis is the acquisition of new chromosomal abnormalities (in addition to the Philadelphia chromosome).<ref name="Faderl1990"/> Some patients may already be in the accelerated phase or blast crisis by the time they are diagnosed.<ref name="Tefferi"/>
| |
| | |
| ===Chronic phase===
| |
| Approximately 85% of patients with CML are in the chronic phase at the time of diagnosis. During this phase, patients are usually asymptomatic or have only mild symptoms of fatigue or abdominal fullness. The duration of chronic phase is variable and depends on how early the disease was diagnosed as well as the therapies used. Ultimately, in the absence of curative treatment, the disease progresses to an accelerated phase.<ref name="Tefferi"/>
| |
| | |
| ===Accelerated phase===
| |
| Criteria for diagnosing transition into the accelerated phase are somewhat variable; the most widely used criteria are those put forward by investigators at M.D. Anderson Cancer Center,<ref>{{cite journal | author = Kantarjian H, Dixon D, Keating M, Talpaz M, Walters R, McCredie K, Freireich E | title = Characteristics of accelerated disease in chronic myelogenous leukemia. | journal = Cancer | volume = 61 | issue = 7 | pages = 1441-6 | year = 1988 |pmid=3162181}}</ref> by Sokal et al,<ref>{{cite journal | author = Sokal J, Baccarani M, Russo D, Tura S | title = Staging and prognosis in chronic myelogenous leukemia. | journal = Semin Hematol | volume = 25 | issue = 1 | pages = 49-61 | year = 1988 | id = PMID 3279515}}</ref> and the [[World Health Organization]].<ref>{{cite journal | author = Vardiman J, Harris N, Brunning R | title = The World Health Organization (WHO) classification of the myeloid neoplasms. | journal = Blood | volume = 100 | issue = 7 | pages = 2292-302 | year = 2002 |pmid=12239137|url=http://www.bloodjournal.org/cgi/content/full/100/7/2292|accessdate=2007-09-22}}</ref><ref name="WHO"/> The WHO criteria are perhaps most widely used, and include:
| |
| *10–19% [[myeloblast]]s in the blood or [[bone marrow]]
| |
| *>20% [[basophil]]s in the blood or bone marrow
| |
| *[[Platelet]] count <100,000, unrelated to therapy
| |
| *Platelet count >1,000,000, unresponsive to therapy
| |
| *Cytogenetic evolution with new abnormalities in addition to the Philadelphia chromosome
| |
| *Increasing [[splenomegaly]] or white blood cell count, unresponsive to therapy
| |
| | |
| The patient is considered to be in the accelerated phase if any of the above are present. The accelerated phase is significant because it signals that the disease is progressing and transformation to blast crisis is imminent.<ref name="WHO"/>
| |
| | |
| ===Blast crisis===
| |
| Blast crisis is the final phase in the evolution of CML, and behaves like an [[acute leukemia]], with rapid progression and short survival.<ref name="Tefferi"/> Blast crisis is diagnosed if any of the following are present in a patient with CML:<ref>{{cite journal|title=Blastic phase of chronic myelogenous leukemia|author=Karbasian Esfahani M, Morris EL, Dutcher JP, Wiernik PH|date=2006|journal=Current Treatment Options in Oncology|volume=7|issue=3|pages=189-199|pmid= 16615875}}</ref>
| |
| *>20% [[myeloblast]]s or [[lymphoblast]]s in the blood or bone marrow
| |
| *Large clusters of blasts in the bone marrow on [[bone marrow biopsy|biopsy]]
| |
| *Development of a [[chloroma]] (solid focus of leukemia outside the bone marrow)
| |
|
| |
|
| ==Treatment== | | ==Treatment== |
| ===Overview=== | | ====Medical therapy:==== |
| In general, CML treatment options are divided into two groups: those that do not increase survival and those that do. Chemotherapeutic drugs such as hydroxyurea (Hydrea®) and busulfan (Myleran®) can normalize the blood count for a period of time, but they do not increase survival. They often are used to control blood counts in patients who cannot undergo SCT or who do not respond to interferon therapy because of age or medical considerations.
| | [[Chronic myelogenous leukemia medical therapy#Overview|Overview]] | [[Chronic myelogenous leukemia medical therapy#Pre-Treatment|Pre-Treatment]] | [[Chronic myelogenous leukemia medical therapy#Chronic phase|Chronic phase]] | [[Chronic myelogenous leukemia medical therapy#Blast crisis|Blast crisis]] | [[Chronic myelogenous leukemia medical therapy#Leukapheresis|Leukapheresis]] | [[Chronic myelogenous leukemia medical therapy#Tyrosine kinase inhibitor therapy|Tyrosine kinase inhibitor therapy]] | [[Chronic myelogenous leukemia medical therapy#Chemotherapy|Chemotherapy]] | [[Chronic myelogenous leukemia medical therapy#Biologic therapy|Biologic therapy]] | [[Chronic myelogenous leukemia medical therapy#High-dose chemotherapy with stem cell transplant|High-dose chemotherapy with stem cell transplant]] | [[Chronic myelogenous leukemia medical therapy#Donor lymphocyte infusion (DLI)|Donor lymphocyte infusion (DLI)]] |
|
| |
|
| [[Gleevec]], is one of a new class of cancer drugs that disables an abnormal enzyme in the cancerous cell, kills it, but leaves healthy cells virtually untouched. Other cancer therapies, such as chemotherapy, attack healthy cells as well as cancer cells, leaving patients with unpleasant and often severe side effects. | | ====Current treatment protocol:==== |
| | [[Chronic myelogenous leukemia current treatment protocol#Chronic Phase Chronic Myelogenous Leukemia|Chronic phase CML]] | [[Chronic myelogenous leukemia current treatment protocol#Accelerated Phase Chronic Myelogenous Leukemia|Accelerated phase CML]] | [[Chronic myelogenous leukemia current treatment protocol#Blastic Phase Chronic Myelogenous Leukemia|Blastic phase CML]] | [[Chronic myelogenous leukemia current treatment protocol#Relapsed Chronic Myelogenous Leukemia|Relapsed CML]] |
|
| |
|
| In June of 2006, the Food and Drug Administration (FDA) approved the oral tyrosine kinase inhibitor dasatinib (Sprycel(tm)) to treat CML that does not respond to other therapy.
| | ====Surgical therapy:==== |
| | [[Chronic myelogenous leukemia surgery|Surgery]] |
|
| |
|
| One treatment that does impact on CML survival is allogeneic bone marrow transplantation, the use of high dose chemotherapy and radiation followed by infusion of a donor bone marrow. This procedure removes the chromosomal abnormality in a large percentage of patients and for them is curative. In addition, there is treatment with interferon (INF). About 20% to 30% of patients taking interferon show elimination of the abnormal chromosome and improved survival. Recent findings also suggest that low-dose cytarabine (ara-C), in combination with interferon, may be more beneficial than interferon alone. For patients who do not respond to interferon, autologous or allogeneic stem cell transplantation is the only alternative.
| | ====Prevention:==== |
| | [[Chronic myelogenous leukemia primary prevention|Primary Prevention]] | [[Chronic myelogenous leukemia secondary prevention|Secondary Prevention]] |
|
| |
|
| Patients with advanced-phase disease may be treated with cytotoxic drugs. For example, individuals showing myeloid transformation may be given drugs that are used to induce remission in AML - that is, daunorubicin and cytarabine, with or without 6-thioguanine or etoposide. Blast cell numbers will be reduced temporarily, but they will increase again within 3 to 6 weeks. Individuals showing lymphoid transformation have a slightly better outlook. They are treated with drugs used in the management of acute lymphocytic leukemia (ALL) - that is, prednisone, vincristine, and daunorubicin, with or without L-asparaginase.
| | ==Resources== |
| | |
| New drugs that are being studied in clinical trials of CML include homoherringtonine with interferon-alpha (INF-a), paclitaxel (Taxol®), QS21 (a plant extract that heightens immune responses), and amifostin (a chemical that lessens some side effects of chemotherapy). In addition, clinical trials are evaluating the potential benefits of substances such as vaccines, monoclonal antibodies (immunologic substances that can direct the patient's immune system to kill cancer cells), and hormones (e.g., growth factors, interleukins).
| |
| | |
| ===Pre-Treatment=== | |
| '''HLA (human leukocyte antigen) typing''' of all patients under age 60, as well as typing of siblings, parents, and children, if available. This procedure will determine whether a compatible donor is available for stem cell transplantation.
| |
| | |
| '''Pre-treatment fertility measures''' (e.g., cryopreservation of semen prior to treatment; completion of a pregnancy prior to treatment) in young patients who have not completed their families.
| |
| | |
| ===Chronic phase===
| |
| Chronic phase CML is treated with inhibitors of [[tyrosine kinase]] , the first of which was [[Imatinib|imatinib mesylate]] (marketed as Gleevec® or Glivec®; previously known as STI-571). In the past, antimetabolites (e.g. [[cytarabine]], [[hydroxyurea]]), [[alkylating antineoplastic agent|alkylating agent]]s, [[Interferon|interferon alfa 2b]], and [[steroid]]s were used, but these drugs have been replaced by imatinib. Imatinib was approved by the United States [[Food and Drug Administration|FDA]] in 2001 and specifically targets BCR/abl, the constitutively activated tyrosine kinase fusion protein caused by the [[Philadelphia chromosome]] translocation. It is better tolerated and more effective than previous therapies. [[Bone marrow transplant|Bone marrow transplantation]] was also used as initial treatment for CML in younger patients before the advent of imatinib, and while it can often be curative, there is a high rate of transplant-related mortality.<ref name="Hehlmann"/>
| |
| | |
| To overcome imatinib resistance and to increase responsiveness to TK inhibitors, two novel agents are currently undergoing [[clinical trials]]. The first, [[dasatinib]], is a TK inhibitor that blocks several oncogenic proteins and has been recently approved by the US FDA to treat CML patients who are either resistant to or intolerant of imatinib. Dasatanib and Imatinib resistance is caused by the T315I mutation. One drug to overcome this resistance is being developed by Merck (MK-0457, formerly known as VX-680), however, enrollments in this clinical trial are currently suspended, pending a full analysis of all efficacy and safety data <ref>FDANEWS.Nov 26 volume5 (230)</ref>. Another drug in development for the T315I mutation is Omacetaxine (formerly known as Ceflatonin®). Clinical data from the first 21 patients enrolled in a Phase 2/3 trial were presented at the American Society of Hematology (ASH) Annual Meeting <ref> Khoury, HJ. et al. Safety and Efficacy Study of Subcutenous Homoharringtonine(SC HHT) in Imatinib (IM)-Resistanct Chronic Myeloid Leukemia (CML) with the T315I Mutation-Intial report of a Phase II Trial (2007)Blood. 110(11):318a</ref>. Another agent, nilotinib, is a selective kinase inhibitor, but is currently undergoing clinical development and testing. Nilotinib is designed to bind more tightly than imatinib to the Bcr-Abl abnormal fusion protein responsible for chronic myeloid leukemia. [[Stem cell treatments|Stem cell transplantation]] is a secondary option for treatment of CML.<ref name=Jabbour>{{cite journal|title=Current and emerging treatment options in chronic myeloid leukemia|author=Jabbour E, Cortes JE, Giles FJ, O'Brien S, Kantarjian HM|journal=Cancer|date=2007|volume=109|issue=11|pages=2171-2181|pmid=17431887}}</ref><ref>{{cite journal|title=New tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia|author=Kimura S, Ashihara E, Maekawa T|date=2006|journal=Current Pharmaceutical Biotechnology|volume=7|issue=5|pages=371-379|pmid=17076652}}</ref>
| |
| | |
| In 2005 favourable results of [[vaccination]] were reported with the ''BCR/abl'' p210 fusion protein in patients with stable disease, with [[GM-CSF]] as an adjuvant.<ref>{{cite journal|author=Bocchia M, Gentili S, Abruzzese E, Fanelli A, Iuliano F, Tabilio A, Amabile M, Forconi F, Gozzetti A, Raspadori D, Amadori S, Lauria F|title=Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial|journal=Lancet|date=2005|volume=365|issue=9460|pages=657-62|pmid= 15721470}}</ref>
| |
| | |
| ===Blast crisis===
| |
| ''Blast crisis'' carries all the symptoms and characteristics of either [[acute myelogenous leukemia]] or [[acute lymphoblastic leukemia]], and has a very high [[death|mortality]] rate. This stage can most effectively be treated by a [[bone marrow transplant]] after high-dose [[chemotherapy]]. In young patients in the accelerated phase, a transplant may also be an option. However the likelihood of relapse after a bone marrow transplant is higher in patients in blast crisis or in the accelerated phase as compared to patients in the chronic phase.<ref name="Jabbour"/>
| |
| | |
| ===There are different types of treatment for patients with chronic myelogenous leukemia===
| |
| | |
| Different types of treatment are available for patients with chronic myelogenous leukemia (CML). Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.
| |
| | |
| ===Leukapheresis===
| |
| It is also known as a peripheral blood stem cell transplant, with stem cell cryopreservation (frozen storage) prior to any other treatment. The patient's blood is passed through a machine that removes the stem cells and then returns the blood to the patient. Leukapheresis usually takes 3 or 4 hours to complete. The stem cells may or may not be treated with drugs to kill any cancer cells. The stem cells then are stored until they are transplanted back into the patient.
| |
| | |
| ===Tyrosine kinase inhibitor therapy===
| |
| | |
| A drug called imatinib mesylate is used as initial treatment for certain types of chronic myelogenous leukemia in newly diagnosed patients. It blocks an enzyme called tyrosine kinase that causes stem cells to develop into more white blood cells (granulocytes or blasts) than the body needs. Another tyrosine kinase inhibitor called dasatinib is used to treat patients with certain types of CML that have progressed, and is being studied as an initial treatment.
| |
| | |
| ===Chemotherapy===
| |
| | |
| Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the spinal column, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). The way the chemotherapy is given depends on the type and stage of the cancer being treated.
| |
| | |
| ===Biologic therapy===
| |
| | |
| Biologic therapy is a treatment that uses the patient’s immune system to fight cancer. Substances made by the body or made in a laboratory are used to boost, direct, or restore the body’s natural defenses against cancer. This type of cancer treatment is also called biotherapy or immunotherapy.
| |
| | |
| ===High-dose chemotherapy with stem cell transplant===
| |
| | |
| High-dose chemotherapy with stem cell transplant is a method of giving high doses of chemotherapy and replacing blood-forming cells destroyed by the cancer treatment. Stem cells (immature blood cells) are removed from the blood or bone marrow of the patient or a donor and are frozen and stored. After the chemotherapy is completed, the stored stem cells are thawed and given back to the patient through an infusion. These reinfused stem cells grow into (and restore) the body’s blood cells.
| |
| | |
| ===Donor lymphocyte infusion (DLI)===
| |
| | |
| Donor lymphocyte infusion (DLI) is a cancer treatment that may be used after stem cell transplant. Lymphocytes (a type of white blood cell) from the stem cell transplant donor are removed from the donor’s blood and may be frozen for storage. The donor’s lymphocytes are thawed if they were frozen and then given to the patient through one or more infusions. The lymphocytes see the patient’s cancer cells as not belonging to the body and attack them.
| |
| | |
| ===Surgery===
| |
| | |
| Splenectomy is surgery to remove the spleen.
| |
| | |
| ==Current Treatment Protocols for CML==
| |
| | |
| ===Chronic Phase Chronic Myelogenous Leukemia===
| |
| | |
| Treatment of chronic phase chronic myelogenous leukemia may include the following:
| |
| | |
| * Drug therapy with a tyrosine kinase inhibitor.
| |
| * High-dose chemotherapy with donor stem cell transplant.
| |
| * Biologic therapy (interferon) with or without chemotherapy.
| |
| * Chemotherapy.
| |
| * Splenectomy.
| |
| | |
| ===Accelerated Phase Chronic Myelogenous Leukemia===
| |
| | |
| Treatment of accelerated phase chronic myelogenous leukemia may include the following:
| |
| | |
| * Stem cell transplant.
| |
| * Drug therapy with a tyrosine kinase inhibitor.
| |
| * Biologic therapy (interferon) with or without chemotherapy.
| |
| * High-dose chemotherapy.
| |
| * Chemotherapy.
| |
| * Transfusion therapy to replace red blood cells, platelets, and sometimes white blood cells, to relieve symptoms and improve quality of life.
| |
| | |
| ===Blastic Phase Chronic Myelogenous Leukemia===
| |
| | |
| Treatment of blastic phase chronic myelogenous leukemia may include the following:
| |
| | |
| * Drug therapy with a tyrosine kinase inhibitor.
| |
| * Chemotherapy using one or more drugs.
| |
| * High-dose chemotherapy.
| |
| * Donor stem cell transplant.
| |
| * Chemotherapy as palliative therapy to relieve symptoms and improve quality of life.
| |
| | |
| ===Relapsed Chronic Myelogenous Leukemia===
| |
| | |
| Treatment of relapsed chronic myelogenous leukemia may include the following:
| |
| | |
| * Drug therapy with a tyrosine kinase inhibitor.
| |
| * Donor stem cell transplant.
| |
| * Donor lymphocyte infusion.
| |
| * Biologic therapy (interferon).
| |
| | |
| ==Prognosis==
| |
| In one analysis of several clinical studies, three different risk groups were identified based on a prognostic scoring system that includes several variables: age, spleen size, blast count, platelet count, eosinophil count and basophil count. In the lowest risk group, the median survival time was 98 months. In the middle group, the median was 65 months, and in the highest risk group, the median was about 42 months. Of all patients analyzed, the longest survival time was 117 months.<ref>{{cite journal|title=A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. Writing Committee for the Collaborative CML Prognostic Factors Project Group|author=Hasford J, Pfirrmann M, Hehlmann R, Allan NC, Baccarani M, Kluin-Nelemans JC, Alimena G, Steegmann JL, Ansari H|date=1998|journal=Journal of the National Cancer Institute|volume=90|issue=11|pages=850-858|pmid=9625174}}</ref> However, this study pre-dates the advent of treatments using targetted therapy. A follow-up on patients using imatinib published in the New England Journal of Medicine shows an overall survival rate of 89% after five years.<ref>{{cite journal|title=Five-Year Follow-up of Patients Receiving Imatinib for Chronic Myeloid Leukemia|author=Druker BJ, Guilhot F, O'Brien SG et al |date=2006|volume=355|issue=20| pages=2408-2417|doi=10.1056/NEJMoa062867| url=http://content.nejm.org/cgi/content/full/355/23/2408|pmid=17151364}}</ref>
| |
| | |
| The prognosis (chance of recovery) and treatment options depend on the following:
| |
| | |
| * The patient’s age.
| |
| * The phase of CML.
| |
| * The amount of blasts in the blood or bone marrow.
| |
| * The size of the spleen at diagnosis.
| |
| * The patient’s general health.
| |
| | |
| ==References==
| |
| {{reflist|2}}
| |
| | |
| == External links ==
| |
| * [http://www.leukemia-lymphoma.org/all_page?item_id=8501 The Leukemia & Lymphoma Society] | | * [http://www.leukemia-lymphoma.org/all_page?item_id=8501 The Leukemia & Lymphoma Society] |
| * [http://www.bmtinfonet.org/ Blood & Marrow Transplant Information Network] | | * [http://www.bmtinfonet.org/ Blood & Marrow Transplant Information Network] |
| * [http://leukemia.acor.org/ Association of Cancer Online Resource (ACOR) Leukemia Links] | | * [http://leukemia.acor.org/ Association of Cancer Online Resource (ACOR) Leukemia Links] |
| * [http://www.merck.com/mmhe/sec14/ch176/ch176e.html Merck Manual:Chronic Myelocytic Leukemia (CML)] | | * [http://www.merck.com/mmhe/sec14/ch176/ch176e.html Merck Manual:Chronic Myelocytic Leukemia (CML)] |
|
| |
|
| |
|
| {{Hematology}} | | {{Hematology}} |
| {{SIB}}
| |
|
| |
|
| |
|
| [[Category:Hematology|Chronic myelogenous leukemia]] | | [[Category:Hematology|Chronic myelogenous leukemia]] |
| [[Category:Types of cancer|Chronic myelogenous leukemia]] | | [[Category:Types of cancer|Chronic myelogenous leukemia]] |
| [[Category:Blood disorders|Chronic myelogenous leukemia]] | | [[Category:Blood disorders|Chronic myelogenous leukemia]] |
| | |
| | [[Category:Disease]] |
| | [[Category:Types of cancer]] |
| | |
| [[Category:Hematology]] | | [[Category:Hematology]] |
| [[Category:Oncology]] | | [[Category:Oncology]] |
|
| |
|
| |
| {{Link FA|ar}}
| |
|
| |
|
| [[ar:ابيضاض الدم النقوي المزمن]] | | [[ar:ابيضاض الدم النقوي المزمن]] |