Chronic diarrhea medical therapy: Difference between revisions

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==Medical Therapy==
==Medical Therapy==
For the treatment of the most common causes of chronic diarrhea, please see below;
*Inflammatory diarrhea
**[[Crohn's disease medical therapy#Medical Therapy|Chrohn's disease]]
**Ulcerative colitis
**Tuberculosis
**Strongyloidiasis
**Ischemic colitis


Antidiarrheal drugs are prescribed depending on the underlying mechanism for example, in a patient with [[Zollinger-Ellison syndrome|Zollinger-ellison syndrome]] (ZES) where hypersecretion of [[gastrin]] is the underlying cause of the diarrhea, [[Proton pump inhibitor|proton pump inhibitors]] can be used.<ref name="pmid7605866">{{cite journal| author=Schiller LR| title=Review article: anti-diarrhoeal pharmacology and therapeutics. | journal=Aliment Pharmacol Ther | year= 1995 | volume= 9 | issue= 2 | pages= 87-106 | pmid=7605866 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7605866  }} </ref> Below are some of the drugs that can be used in the symptomatic treatment of chronic diarrhea and some of their mechanisms of actions. Some drugs have numerous mechanisms of action and can thus be found under more than one sections. It is important to know that these drugs are used for the symptomatic treatment of chronic diarrhea. In order to appropriately treat chronic diarrhea, the underlying cause of the disease must be identified.
*Watery diarrhea
**Celiac sprue
**Chronic pancreatitis
**Lactase deficiency
**Whipple's disease
**Cholera
**Giardia
**Hyperthyroidism
**Addison's disease
 
*Fatty diarrhea
**Celiac sprue
**Pancreatic insufficiency
**Bacterial overgrowth
 
 
Some antidiarrheal drugs are prescribed depending on the underlying mechanism for example, in a patient with [[Zollinger-Ellison syndrome|Zollinger-ellison syndrome]] (ZES) where hypersecretion of [[gastrin]] is the underlying cause of the diarrhea, [[Proton pump inhibitor|proton pump inhibitors]] can be used. This drugs are used primarily for symptomatic relief prior to identifying the cause of the diarrhea<ref name="pmid7605866">{{cite journal| author=Schiller LR| title=Review article: anti-diarrhoeal pharmacology and therapeutics. | journal=Aliment Pharmacol Ther | year= 1995 | volume= 9 | issue= 2 | pages= 87-106 | pmid=7605866 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7605866  }} </ref> Below are some of the drugs that can be used in the symptomatic treatment of chronic diarrhea and some of their mechanisms of actions. Some drugs have numerous mechanisms of action and can thus be found under more than one sections. It is important to know that these drugs are used for the symptomatic treatment of chronic diarrhea. In order to appropriately treat chronic diarrhea, the underlying cause of the disease must be identified.


'''Inhibitors of intestinal transit time'''
'''Inhibitors of intestinal transit time'''

Revision as of 11:57, 10 July 2017

Chronic diarrhea Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Chronic diarrhea from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]

Overview

Antidiarrheal drugs can be broadly defined as agents that minimize the symptoms of diarrhea by improving stool consistency, reducing stool frequency, or reducing stool weight.[1]

Medical Therapy

For the treatment of the most common causes of chronic diarrhea, please see below;

  • Inflammatory diarrhea
    • Chrohn's disease
    • Ulcerative colitis
    • Tuberculosis
    • Strongyloidiasis
    • Ischemic colitis
  • Watery diarrhea
    • Celiac sprue
    • Chronic pancreatitis
    • Lactase deficiency
    • Whipple's disease
    • Cholera
    • Giardia
    • Hyperthyroidism
    • Addison's disease
  • Fatty diarrhea
    • Celiac sprue
    • Pancreatic insufficiency
    • Bacterial overgrowth


Some antidiarrheal drugs are prescribed depending on the underlying mechanism for example, in a patient with Zollinger-ellison syndrome (ZES) where hypersecretion of gastrin is the underlying cause of the diarrhea, proton pump inhibitors can be used. This drugs are used primarily for symptomatic relief prior to identifying the cause of the diarrhea[1] Below are some of the drugs that can be used in the symptomatic treatment of chronic diarrhea and some of their mechanisms of actions. Some drugs have numerous mechanisms of action and can thus be found under more than one sections. It is important to know that these drugs are used for the symptomatic treatment of chronic diarrhea. In order to appropriately treat chronic diarrhea, the underlying cause of the disease must be identified.

Inhibitors of intestinal transit time

Pro-absorptive agents

Antisecretory drugs

Intraluminal agents

References

  1. ↑ 1.0 1.1 Schiller LR (1995). "Review article: anti-diarrhoeal pharmacology and therapeutics". Aliment Pharmacol Ther. 9 (2): 87–106. PMID 7605866.


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