Chronic diarrhea medical therapy: Difference between revisions

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==Overview==
==Overview==
Antidiarrheal drugs can be broadly defined as agents that minimize the symptoms of diarrhea by improving stool consistency, reducing stool frequency, or reducing stool weight.<ref name="pmid7605866">{{cite journal| author=Schiller LR| title=Review article: anti-diarrhoeal pharmacology and therapeutics. | journal=Aliment Pharmacol Ther | year= 1995 | volume= 9 | issue= 2 | pages= 87-106 | pmid=7605866 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7605866  }} </ref>
[[Antidiarrheal]] drugs can be broadly defined as agents that minimize the [[symptoms]] of diarrhea by improving stool [[Consistency (statistics)|consistency]], reducing stool [[frequency]], or reducing [[Human feces|stool weight]]. [[Chronic diarrhea]] is a common symptom of many conditions. In order to appropriately treat [[chronic diarrhea]], the underlying causes must be identified and treated and, in most cases, the [[chronic diarrhea]] will resolve.<ref name="pmid7605866">{{cite journal| author=Schiller LR| title=Review article: anti-diarrhoeal pharmacology and therapeutics. | journal=Aliment Pharmacol Ther | year= 1995 | volume= 9 | issue= 2 | pages= 87-106 | pmid=7605866 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7605866  }} </ref>  


==Medical Therapy==
==Medical Therapy==
For the treatment of the most common causes of [[chronic diarrhea]], please click below:
*'''Inflammatory diarrhea'''
**[[Crohn's disease medical therapy#Medical Therapy|Crohn's disease]]
**[[Ulcerative colitis medical therapy#Medical Therapy|Ulcerative colitis]]
**[[Tuberculosis medical therapy#Medical Therapy|Tuberculosis]]
**[[Strongyloidiasis medical therapy#Medical Therapy|Strongyloidiasis]]
**[[Ischemic colitis medical therapy#Medical Therapy|Ischemic colitis]]


Antidiarrheal drugs are prescribed depending on the underlying mechanism for example, in a patient with [[Zollinger-Ellison syndrome|Zollinger-ellison syndrome]] (ZES) where hypersecretion of [[gastrin]] is the underlying cause of the diarrhea, [[Proton pump inhibitor|proton pump inhibitors]] can be used.<ref name="pmid7605866">{{cite journal| author=Schiller LR| title=Review article: anti-diarrhoeal pharmacology and therapeutics. | journal=Aliment Pharmacol Ther | year= 1995 | volume= 9 | issue= 2 | pages= 87-106 | pmid=7605866 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7605866  }} </ref> Below are some of the drugs that can be used in the treatment of chronic diarrhea and some of their mechanisms of actions. Some drugs have numerous mechanisms of action and can thus be found under more than one sections. It is important to know that these drugs are used for the symptomatic treatment of chronic diarrhea. In order to appropriately treat chronic diarrhea, the underlying cause of the disease must be identified.
*'''Watery diarrhea'''
**[[Celiac disease medical therapy#Medical Therapy|Celiac sprue]]
**[[Chronic pancreatitis medical therapy#Medical Therapy|Chronic pancreatitis]]
**[[Lactose intolerance medical therapy#Medical Therapy|Lactose intolerance]]
**[[Whipple's disease medical therapy#Medical Therapy|Whipple's disease]]
**[[Cholera medical therapy#Medical Therapy|Cholera]]
**[[Giardiasis medical therapy#Medical Therapy|Giardiasis]]
**[[Hyperthyroidism medical therapy#Medical Therapy|Hyperthyroidism]]
**[[Addison's disease medical therapy#Medical Therapy|Addison's disease]]
 
*'''Fatty diarrhea'''
**[[Celiac disease medical therapy#Medical Therapy|Celiac disease]]
**[[Pancreatic insufficiency#Treatment|Pancreatic insufficiency]]
**[[Small bowel bacterial overgrowth syndrome#Treatment|Small bowel bacterial overgrowth syndrome]]
 
Below are some of the [[drugs]] that can be used in the symptomatic treatment of chronic [[diarrhea]] and their mechanisms of action. Some [[drugs]] have numerous mechanisms of action and can thus be found under more than one section. It is important to know that these [[drugs]] are used for the [[symptomatic]] treatment of chronic [[diarrhea]]. In order to appropriately treat chronic [[diarrhea]], the underlying cause of the [[disease]] must be identified.<ref name="pmid7605866">{{cite journal| author=Schiller LR| title=Review article: anti-diarrhoeal pharmacology and therapeutics. | journal=Aliment Pharmacol Ther | year= 1995 | volume= 9 | issue= 2 | pages= 87-106 | pmid=7605866 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7605866  }} </ref>


'''Inhibitors of intestinal transit time'''
'''Inhibitors of intestinal transit time'''
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**[[Lanreotide]]
**[[Lanreotide]]
**[[Pasireotide]]
**[[Pasireotide]]
*[[Enterocyte]] apical membrane chloride channel inhibitors
*[[Enterocyte]] apical membrane [[chloride channel]] inhibitors
**[[Crofelemer]]
**[[Crofelemer]]
*[[Berberine]]
*[[Berberine]]
*[[Calcium channel blockers]]
*[[Calcium channel blockers]]
**[[Nifedipine]]
**[[Nifedipine]]
*Calmodulin inhibitors
*[[Calmodulin]] inhibitors
**[[Chlorpromazine]]
**[[Chlorpromazine]]
**[[Trifluoperazine]]
**[[Trifluoperazine]]
*[[Calcium-sensing receptor|Calcium-sensing receptor ligands]]
*[[Calcium-sensing receptor|Calcium-sensing receptor ligands]]
**[[Calcium]]
*[[Nicotinic acid]]
*[[Nicotinic acid]]
*[[Lithium]]
*[[Lithium]]
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{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category:Emergency medicine]]
[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Infectious disease]]
[[Category:Gastroenterology]]
[[Category:Pediatrics]]

Latest revision as of 20:57, 29 July 2020

Chronic diarrhea Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Chronic diarrhea from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]

Overview

Antidiarrheal drugs can be broadly defined as agents that minimize the symptoms of diarrhea by improving stool consistency, reducing stool frequency, or reducing stool weight. Chronic diarrhea is a common symptom of many conditions. In order to appropriately treat chronic diarrhea, the underlying causes must be identified and treated and, in most cases, the chronic diarrhea will resolve.[1]

Medical Therapy

For the treatment of the most common causes of chronic diarrhea, please click below:

Below are some of the drugs that can be used in the symptomatic treatment of chronic diarrhea and their mechanisms of action. Some drugs have numerous mechanisms of action and can thus be found under more than one section. It is important to know that these drugs are used for the symptomatic treatment of chronic diarrhea. In order to appropriately treat chronic diarrhea, the underlying cause of the disease must be identified.[1]

Inhibitors of intestinal transit time

Pro-absorptive agents

Antisecretory drugs

Intraluminal agents

References

  1. ↑ 1.0 1.1 Schiller LR (1995). "Review article: anti-diarrhoeal pharmacology and therapeutics". Aliment Pharmacol Ther. 9 (2): 87–106. PMID 7605866.


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