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{{Chondrosarcoma}}
{{Chondrosarcoma}}
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{{CMG}}; {{AE}} {{Rohan}}
==Overview==
==Overview==
Chondrosarcoma may be classified into six subtypes based on topographical location of tumor, histological characteristics, and makeup of surrounding matrix material.
Chondrosarcoma may be classified based on histological findings and location.
==Classification==
==Classification==
Chondrosarcoma may be classified into six subtypes based on the topographical location of the tumor, the histological characteristics of the cancerous cartilage cells, the makeup of the surrounding matrix material associated with the tumor
*Chondrosarcoma be classified based on [[Histology|histological findings]] and location.
 
===Histological Classification===
*Chondrosarcoma may be classified based on [[Histological|histological findings]] into following groups:<ref name="pmid8378694">{{cite journal| author=Raymond E, L'Her P, Jeanbourquin D, Schill H, Jancovici R, Daly JP et al.| title=[Chondrosarcoma of the thoracic wall. Review of the literature apropos of 4 cases]. | journal=Rev Pneumol Clin | year= 1993 | volume= 49 | issue= 1 | pages= 19-25 | pmid=8378694 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8378694  }} </ref><ref name="pmid30559960">{{cite journal| author=Lex JR, Evans S, Stevenson JD, Parry M, Jeys LM, Grimer RJ| title=Dedifferentiated chondrosarcoma of the pelvis: clinical outcomes and current treatment. | journal=Clin Sarcoma Res | year= 2018 | volume= 8 | issue=  | pages= 23 | pmid=30559960 | doi=10.1186/s13569-018-0110-1 | pmc=6293503 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30559960  }} </ref>
 
'''Primary Chondrosarcoma'''
*Chondrosarcoma that arises denovo and comprises of following subtypes:
**Conventional chondrosarcoma - Low-grade, high-grade, and dedifferentiated chondrosarcoma (90% of all chondrosarcomas)
**Clear cell chondrosarcoma (1% of all chondrosarcomas)
**Mesenchymal chondrosarcoma (2% of all chondrosarcomas)


*Chondrosarcoma NOS ("Not Otherwise Specified")
'''Secondary Chondrosarcoma'''
*Juxtacortical chondrosarcoma
*Chondrosarcoma that arises from [[benign]] [[cartilage]] lesions includes (7% of all chondrosarcomas):
*Myxoid chondrosarcoma
**[[Osteochondroma]] (<1% risk of [[malignant]] transfomation)
*Mesenchymal chondrosarcoma
**Multiple hereditary exostosis (1-10% risk of [[malignant]] transformation)
*Clear cell chondrosarcoma
**[[Enchondroma|Enchondromas]] (1% risk of [[malignant]] transformation)
*Dedifferentiated chondrosarcoma
**[[Enchondroma|Ollier's disease]] (25-40% risk of [[malignant]] transformation)
**[[Maffucci's disease]](100% risk of [[malignant]] transformation)
 
===Based on Location===
*Chondrosarcoma may be classified based on location into following groups:<ref name="pmid19411454">{{cite journal| author=Giuffrida AY, Burgueno JE, Koniaris LG, Gutierrez JC, Duncan R, Scully SP| title=Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database. | journal=J Bone Joint Surg Am | year= 2009 | volume= 91 | issue= 5 | pages= 1063-72 | pmid=19411454 | doi=10.2106/JBJS.H.00416 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19411454  }} </ref><ref name="pmid17908885">{{cite journal| author=Skeletal Lesions Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group| title=Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones. | journal=J Bone Joint Surg Am | year= 2007 | volume= 89 | issue= 10 | pages= 2113-23 | pmid=17908885 | doi=10.2106/JBJS.F.01530 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17908885  }} </ref>
**Centrally located within the [[medullary cavity]]. (central chondrosarcoma) (70% of all chondrosarcomas)
**Peripherally located on the surface of bone as a result of [[malignant]] transformation within the [[cartilaginous]] cap. (Peripheral chondrosarcoma) (15% of all chondrosarcomas)


==References==
==References==
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Latest revision as of 15:52, 24 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rohan A. Bhimani, M.B.B.S., D.N.B., M.Ch.[2]

Overview

Chondrosarcoma may be classified based on histological findings and location.

Classification

Histological Classification

Primary Chondrosarcoma

  • Chondrosarcoma that arises denovo and comprises of following subtypes:
    • Conventional chondrosarcoma - Low-grade, high-grade, and dedifferentiated chondrosarcoma (90% of all chondrosarcomas)
    • Clear cell chondrosarcoma (1% of all chondrosarcomas)
    • Mesenchymal chondrosarcoma (2% of all chondrosarcomas)

Secondary Chondrosarcoma

Based on Location

  • Chondrosarcoma may be classified based on location into following groups:[3][4]
    • Centrally located within the medullary cavity. (central chondrosarcoma) (70% of all chondrosarcomas)
    • Peripherally located on the surface of bone as a result of malignant transformation within the cartilaginous cap. (Peripheral chondrosarcoma) (15% of all chondrosarcomas)

References

  1. Raymond E, L'Her P, Jeanbourquin D, Schill H, Jancovici R, Daly JP; et al. (1993). "[Chondrosarcoma of the thoracic wall. Review of the literature apropos of 4 cases]". Rev Pneumol Clin. 49 (1): 19–25. PMID 8378694.
  2. Lex JR, Evans S, Stevenson JD, Parry M, Jeys LM, Grimer RJ (2018). "Dedifferentiated chondrosarcoma of the pelvis: clinical outcomes and current treatment". Clin Sarcoma Res. 8: 23. doi:10.1186/s13569-018-0110-1. PMC 6293503. PMID 30559960.
  3. Giuffrida AY, Burgueno JE, Koniaris LG, Gutierrez JC, Duncan R, Scully SP (2009). "Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database". J Bone Joint Surg Am. 91 (5): 1063–72. doi:10.2106/JBJS.H.00416. PMID 19411454.
  4. Skeletal Lesions Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group (2007). "Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones". J Bone Joint Surg Am. 89 (10): 2113–23. doi:10.2106/JBJS.F.01530. PMID 17908885.

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