Chenodeoxycholic acid

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Chenodeoxycholic acid
Systematic name	chenodiol 3α,7α-dihydroxy-5β-cholanic acid 5β-cholanic acid-3α,7α-diol
Chemical formula	C24H40O4
Molecular mass	xx.xx g/mol
Density	x.xxx g/cm3
Melting point	165-167 °C
Boiling point	xx.x °C
CAS number	[474-25-9]
SMILES	C[C@@]34[C@] (CC[C@@H]4[C@@H] (CCC(O)=O)C) ([H])[C@]2([H]) [C@H](O)C[C@]1 ([H])C[C@H](O) CC[C@@](C)1 [C@]([H])2CC3
Disclaimer and references

WikiDoc Resources for Chenodeoxycholic acid
Articles
Most recent articles on Chenodeoxycholic acid Most cited articles on Chenodeoxycholic acid Review articles on Chenodeoxycholic acid Articles on Chenodeoxycholic acid in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Chenodeoxycholic acid Images of Chenodeoxycholic acid Photos of Chenodeoxycholic acid Podcasts & MP3s on Chenodeoxycholic acid Videos on Chenodeoxycholic acid
Evidence Based Medicine
Cochrane Collaboration on Chenodeoxycholic acid Bandolier on Chenodeoxycholic acid TRIP on Chenodeoxycholic acid
Clinical Trials
Ongoing Trials on Chenodeoxycholic acid at Clinical Trials.gov Trial results on Chenodeoxycholic acid Clinical Trials on Chenodeoxycholic acid at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Chenodeoxycholic acid NICE Guidance on Chenodeoxycholic acid NHS PRODIGY Guidance FDA on Chenodeoxycholic acid CDC on Chenodeoxycholic acid
Books
Books on Chenodeoxycholic acid
News
Chenodeoxycholic acid in the news Be alerted to news on Chenodeoxycholic acid News trends on Chenodeoxycholic acid
Commentary
Blogs on Chenodeoxycholic acid
Definitions
Definitions of Chenodeoxycholic acid
Patient Resources / Community
Patient resources on Chenodeoxycholic acid Discussion groups on Chenodeoxycholic acid Patient Handouts on Chenodeoxycholic acid Directions to Hospitals Treating Chenodeoxycholic acid Risk calculators and risk factors for Chenodeoxycholic acid
Healthcare Provider Resources
Symptoms of Chenodeoxycholic acid Causes & Risk Factors for Chenodeoxycholic acid Diagnostic studies for Chenodeoxycholic acid Treatment of Chenodeoxycholic acid
Continuing Medical Education (CME)
CME Programs on Chenodeoxycholic acid
International
Chenodeoxycholic acid en Espanol Chenodeoxycholic acid en Francais
Business
Chenodeoxycholic acid in the Marketplace Patents on Chenodeoxycholic acid
Experimental / Informatics
List of terms related to Chenodeoxycholic acid

Chenodeoxycholic acid (also known as chenodesoxycholic acid) is a bile acid, a white crystalline substance insoluble in water, with melting point at 165-167 °C. Its salts is called chenodeoxycholates. Chenodeoxycholic acid is one of the 4 main organic acids produced by the liver. It is soluble in alcohol and acetic acid.

Chenodeoxycholic acid is synthesized in the liver from cholesterol.

This compound, when altered by bacteria in the colon, will result in conversion to its secondary bile acid known as lithocholic acid. Both of these bile acids, in addition to the others, can be conjugated to taurine or glycine. Conjugation, a function carried out by the liver will result in a lowered pKa and therefore, the compounds will remain ionized. These ionized compounds will stay in the gastrointestinal tract until reaching the ileum where they will be reabsorbed. The purpose of this conjugation is to keep the bile acids in the tract until the end to facilitate lipid digestion all the way to the ileum.

In cases where bacteria overgrow in the small intestine, often due to a blind loop in the intestine retaining chyme in one place, the bacteria will de-conjugate the bile acids and therefore impede fat digestion and absorption. This can lead to steatorrhea.

Chenodeoxycholic acid and cholic acid are the most important human bile acids. Some other mammals synthesize predominantly deoxycholic acid.

Potential applications

The Australian biotechnology company Giaconda has developed a treatment for Hepatitis C infection that combines chenodeoxycholic acid with bezafibrate.

In supramolecular chemistry molecular tweezers based on a chenodeoxycholic acid scaffold is an urea receptor ^[2] which can contain anions in its binding pocket in order of affinity: H₂PO₄^- (dihydrogen phosphate) > Cl^- > Br^- > I^- reflecting their basicities (tetrabutylammonium counter ion).

References

Cost Effectiveness of Chenodeoxycholic acid

| group5 = Clinical Trials Involving Chenodeoxycholic acid | list5 = Ongoing Trials on Chenodeoxycholic acid at Clinical Trials.gov • Trial results on Chenodeoxycholic acid • Clinical Trials on Chenodeoxycholic acid at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Chenodeoxycholic acid | list6 = US National Guidelines Clearinghouse on Chenodeoxycholic acid • NICE Guidance on Chenodeoxycholic acid • NHS PRODIGY Guidance • FDA on Chenodeoxycholic acid • CDC on Chenodeoxycholic acid

| group7 = Textbook Information on Chenodeoxycholic acid | list7 = Books and Textbook Information on Chenodeoxycholic acid

| group8 = Pharmacology Resources on Chenodeoxycholic acid | list8 = AND (Dose)}} Dosing of Chenodeoxycholic acid • AND (drug interactions)}} Drug interactions with Chenodeoxycholic acid • AND (side effects)}} Side effects of Chenodeoxycholic acid • AND (Allergy)}} Allergic reactions to Chenodeoxycholic acid • AND (overdose)}} Overdose information on Chenodeoxycholic acid • AND (carcinogenicity)}} Carcinogenicity information on Chenodeoxycholic acid • AND (pregnancy)}} Chenodeoxycholic acid in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Chenodeoxycholic acid •

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Chenodeoxycholic acid | list9 = AND (pharmacogenomics)}} Genetics of Chenodeoxycholic acid • AND (pharmacogenomics)}} Pharmacogenomics of Chenodeoxycholic acid • AND (proteomics)}} Proteomics of Chenodeoxycholic acid

| group10 = Newstories on Chenodeoxycholic acid | list10 = Chenodeoxycholic acid in the news • Be alerted to news on Chenodeoxycholic acid • News trends on Chenodeoxycholic acid</small>

| group11 = Commentary on Chenodeoxycholic acid | list11 = Blogs on Chenodeoxycholic acid

| group12 = Patient Resources on Chenodeoxycholic acid | list12 = Patient resources on Chenodeoxycholic acid • Discussion groups on Chenodeoxycholic acid • Patient Handouts on Chenodeoxycholic acid • Directions to Hospitals Treating Chenodeoxycholic acid • Risk calculators and risk factors for Chenodeoxycholic acid

| group13 = Healthcare Provider Resources on Chenodeoxycholic acid | list13 = Symptoms of Chenodeoxycholic acid • Causes & Risk Factors for Chenodeoxycholic acid • Diagnostic studies for Chenodeoxycholic acid • Treatment of Chenodeoxycholic acid

| group14 = Continuing Medical Education (CME) Programs on Chenodeoxycholic acid | list14 = CME Programs on Chenodeoxycholic acid

| group15 = International Resources on Chenodeoxycholic acid | list15 = Chenodeoxycholic acid en Espanol • Chenodeoxycholic acid en Francais

| group16 = Business Resources on Chenodeoxycholic acid | list16 = Chenodeoxycholic acid in the Marketplace • Patents on Chenodeoxycholic acid

| group17 = Informatics Resources on Chenodeoxycholic acid | list17 = List of terms related to Chenodeoxycholic acid

}}