Chelation therapy for cardiovascular disease: Difference between revisions

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==Mechanism of Action==
==Mechanism of Action==
Ethylenediamine tetraacetic acid (EDTA), a type of chelation therapy, binds to metals and forms a soluble complex which facilitates their subsequent excretion in the [[urine]].<ref name="pmid14000694">{{cite journal| author=WILDER LW, DE JODE LR, MILSTEIN SW, HOWARD JM| title=Mobilization of atherosclerotic plaque calcium with EDTA utilizing the isolation-perfusion principle. | journal=Surgery | year= 1962 | volume= 52 | issue= | pages= 793-5 | pmid=14000694 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14000694 }} </ref>  Hence, chelation therapy helps in the elimination of metals including [[lead]], [[iron]], [[copper]] and [[calcium]] from the blood. The chelation therapy consists of [[EDTA]] along with additives such as [[vitamin B]], [[ascorbic acid]] and [[magnesium]] which are thought to have a protective effect on the [[endothelial cells]].<ref name="pmid10874253">{{cite journal| author=Lamas GA, Ackermann A| title=Clinical evaluation of chelation therapy: is there any wheat amidst the chaff? | journal=Am Heart J | year= 2000 | volume= 140 | issue= 1 | pages= 4-5 | pmid=10874253 | doi=10.1067/mhj.2000.107549 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10874253 }} </ref>  Cardiovascular benefits are thought to result from the antioxidant effects of the chelation therapy as it decreases the metal-dependent formation of [[reactive oxygen species]] and lipid peroxidation.<ref name="pmid10874253">{{cite journal| author=Lamas GA, Ackermann A| title=Clinical evaluation of chelation therapy: is there any wheat amidst the chaff? | journal=Am Heart J | year= 2000 | volume= 140 | issue= 1 | pages= 4-5 | pmid=10874253 | doi=10.1067/mhj.2000.107549 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10874253 }} </ref>  In addition, removal of calcium from arterial wall by chelation therapy can possibly lead to a regression in the atherosclerotic plaque.<ref name="pmid13810514">{{cite journal| author=CLARKE NE| title=Atherosclerosis, occlusive vascular disease and EDTA. | journal=Am J Cardiol | year= 1960 | volume= 6 | issue= | pages= 233-6 | pmid=13810514 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13810514 }} </ref><ref name="pmid14033183">{{cite journal| author=KITCHELL JR, PALMON F, AYTAN N, MELTZER LE| title=The treatment of coronary artery disease with disodium EDTA. A reappraisal. | journal=Am J Cardiol | year= 1963 | volume= 11 | issue= | pages= 501-6 | pmid=14033183 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14033183 }} </ref>
Ethylenediamine tetraacetic acid (EDTA), a type of chelation therapy, binds to metals and forms soluble complexes facilitating their subsequent excretion in the [[urine]].<ref name="pmid14000694">{{cite journal| author=WILDER LW, DE JODE LR, MILSTEIN SW, HOWARD JM| title=Mobilization of atherosclerotic plaque calcium with EDTA utilizing the isolation-perfusion principle. | journal=Surgery | year= 1962 | volume= 52 | issue= | pages= 793-5 | pmid=14000694 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14000694 }} </ref>  Hence, chelation therapy helps in the elimination of metals including [[lead]], [[iron]], [[copper]] and [[calcium]] from the blood. The chelation therapy consists of [[EDTA]] along with additives such as [[vitamin B]], [[ascorbic acid]] and [[magnesium]] which are thought to have a protective effect on the [[endothelial cells]].<ref name="pmid10874253">{{cite journal| author=Lamas GA, Ackermann A| title=Clinical evaluation of chelation therapy: is there any wheat amidst the chaff? | journal=Am Heart J | year= 2000 | volume= 140 | issue= 1 | pages= 4-5 | pmid=10874253 | doi=10.1067/mhj.2000.107549 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10874253 }} </ref>  Cardiovascular benefits of chelation therapy are thought to result from its antioxidant effect as it decreases the metal-dependent formation of [[reactive oxygen species]] and lipid [[peroxidation]].<ref name="pmid10874253">{{cite journal| author=Lamas GA, Ackermann A| title=Clinical evaluation of chelation therapy: is there any wheat amidst the chaff? | journal=Am Heart J | year= 2000 | volume= 140 | issue= 1 | pages= 4-5 | pmid=10874253 | doi=10.1067/mhj.2000.107549 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10874253 }} </ref>  In addition, the removal of calcium from arterial wall by chelation therapy can possibly lead to a regression of the atherosclerotic plaques.<ref name="pmid13810514">{{cite journal| author=CLARKE NE| title=Atherosclerosis, occlusive vascular disease and EDTA. | journal=Am J Cardiol | year= 1960 | volume= 6 | issue= | pages= 233-6 | pmid=13810514 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13810514 }} </ref><ref name="pmid14033183">{{cite journal| author=KITCHELL JR, PALMON F, AYTAN N, MELTZER LE| title=The treatment of coronary artery disease with disodium EDTA. A reappraisal. | journal=Am J Cardiol | year= 1963 | volume= 11 | issue= | pages= 501-6 | pmid=14033183 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14033183 }} </ref>


==Side Effects==
==Side Effects==

Revision as of 14:04, 19 November 2013

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Chelation therapy for post-myocardial infarction, chelation therapy for diabetics

Overview

Chelation Therapy and CVD

Mechanism of Action

Ethylenediamine tetraacetic acid (EDTA), a type of chelation therapy, binds to metals and forms soluble complexes facilitating their subsequent excretion in the urine.[1] Hence, chelation therapy helps in the elimination of metals including lead, iron, copper and calcium from the blood. The chelation therapy consists of EDTA along with additives such as vitamin B, ascorbic acid and magnesium which are thought to have a protective effect on the endothelial cells.[2] Cardiovascular benefits of chelation therapy are thought to result from its antioxidant effect as it decreases the metal-dependent formation of reactive oxygen species and lipid peroxidation.[2] In addition, the removal of calcium from arterial wall by chelation therapy can possibly lead to a regression of the atherosclerotic plaques.[3][4]

Side Effects

Landmark Trials

Stable Patients

Diabetic Patients

References

  1. ↑ WILDER LW, DE JODE LR, MILSTEIN SW, HOWARD JM (1962). "Mobilization of atherosclerotic plaque calcium with EDTA utilizing the isolation-perfusion principle". Surgery. 52: 793–5. PMID 14000694.
  2. ↑ 2.0 2.1 Lamas GA, Ackermann A (2000). "Clinical evaluation of chelation therapy: is there any wheat amidst the chaff?". Am Heart J. 140 (1): 4–5. doi:10.1067/mhj.2000.107549. PMID 10874253.
  3. ↑ CLARKE NE (1960). "Atherosclerosis, occlusive vascular disease and EDTA". Am J Cardiol. 6: 233–6. PMID 13810514.
  4. ↑ KITCHELL JR, PALMON F, AYTAN N, MELTZER LE (1963). "The treatment of coronary artery disease with disodium EDTA. A reappraisal". Am J Cardiol. 11: 501–6. PMID 14033183.


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