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{{Central pontine myelinolysis}}
{{Central pontine myelinolysis}}
{{CMG}}; {{AE}} {{MMJ}}
{{CMG}}; {{AE}} {{sali}}, {{MMJ}}


==Overview==
==Overview==
It is understood that central pontine myelinolysis is caused by the rapid correction of [[hyponatremia]]. The [[CNS]] is particularly susceptible to reductions in [[plasma osmolarity]], specially during [[hyponatremia]] which is the most commonly encountered [[electrolyte disturbance]]. When a decrease in the plasma [[osmolarity]] happens, neural cells first swell but then they are able to regain their original volume through the release of inorganic and organic osmolytes and exit of osmotically obligated water. Subsequent exposure to hypertonic stress(e.g., correction of [[hyponatremia]] with hypertonic I.V. solutions)resulting from a rapid correction of [[hyponatremia]] causes the [[ions]] to quickly re-enter the intracellular space and compels the water to follow. If the serum sodium levels rise too rapidly, the increased extracellular tonicity will continue to drive water out of the brain's cells because the brain cells do not have enough time to bring extracellular sodium into the cell, so the water will go out very fast. This can lead to cellular dysfunction and death and finally central pontine myelinolysis.
It is understood that central pontine myelinolysis is caused by the rapid correction of [[hyponatremia]]. The [[CNS]] is particularly susceptible to reductions in [[plasma osmolarity]], specially during [[hyponatremia]] which is the most commonly encountered [[electrolyte disturbance]]. When a decrease in the plasma [[osmolarity]] happens, neural cells first swell but then they are able to regain their original volume through the release of inorganic and organic osmolytes and exit of osmotically obligated water. Subsequent exposure to hypertonic stress(e.g., correction of [[hyponatremia]] with hypertonic I.V. solutions)resulting from a rapid correction of [[hyponatremia]] causes the [[ions]] to quickly re-enter the intracellular space and compels the water to follow. If the serum [[sodium]] levels rise too rapidly, the increased extracellular tonicity will continue to drive water out of the brain's cells because the brain cells do not have enough time to bring extracellular sodium into the cell, so the water goes out very fast. This can lead to cellular dysfunction and central pontine myelinolysis and finally death.


==Pathophysiology==
==Pathophysiology==
===Pathogenesis===
===Pathogenesis===


*It is understood that central pontine myelinolysis is caused by rapid correction of [[hyponatremia]].<ref name="pmid24682140">{{cite journal| author=Mascarenhas JV, Jude EB| title=Central pontine myelinolysis: electrolytes and beyond. | journal=BMJ Case Rep | year= 2014 | volume= 2014 | issue=  | pages=  | pmid=24682140 | doi=10.1136/bcr-2013-203516 | pmc=3975522 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24682140  }} </ref>
*It is understood that central pontine myelinolysis is caused by rapid correction of [[hyponatremia]].<ref name="pmid24682140">{{cite journal| author=Mascarenhas JV, Jude EB| title=Central pontine myelinolysis: electrolytes and beyond. | journal=BMJ Case Rep | year= 2014 | volume= 2014 | issue=  | pages=  | pmid=24682140 | doi=10.1136/bcr-2013-203516 | pmc=3975522 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24682140  }} </ref><ref name="pmid23760391" />
*The [[CNS]] is particularly susceptible to reductions in [[plasma osmolarity]], specially during [[hyponatremia]] which is the most commonly encountered [[electrolyte disturbance]].
*The [[CNS]] is particularly susceptible to reductions in [[plasma osmolarity]], specially during [[hyponatremia]] which is the most commonly encountered [[electrolyte disturbance]].
*When a decrease in the plasma [[osmolarity]] happens, neural cells first swell but then they are able to regain their original volume through the:<ref name="pmid23760391">{{cite journal| author=Khosya S, Meena H| title=Central pontine myelinolysis. | journal=Indian J Med Res | year= 2013 | volume= 137 | issue= 5 | pages= 993-4 | pmid=23760391 | doi= | pmc=3734697 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23760391  }} </ref><ref name="pmid18256030">Burg MB, Ferraris JD (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18256030 Intracellular organic osmolytes: function and regulation.] ''J Biol Chem'' 283 (12):7309-13. [http://dx.doi.org/10.1074/jbc.R700042200 DOI:10.1074/jbc.R700042200] PMID: [https://pubmed.gov/18256030 18256030]</ref>
*When a decrease in the plasma [[osmolarity]] happens, neural cells first swell but then they are able to regain their original volume through the:<ref name="pmid23760391">{{cite journal| author=Khosya S, Meena H| title=Central pontine myelinolysis. | journal=Indian J Med Res | year= 2013 | volume= 137 | issue= 5 | pages= 993-4 | pmid=23760391 | doi= | pmc=3734697 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23760391  }} </ref><ref name="pmid18256030">Burg MB, Ferraris JD (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18256030 Intracellular organic osmolytes: function and regulation.] ''J Biol Chem'' 283 (12):7309-13. [http://dx.doi.org/10.1074/jbc.R700042200 DOI:10.1074/jbc.R700042200] PMID: [https://pubmed.gov/18256030 18256030]</ref>
*#Release of inorganic and organic osmolytes
*#Release of inorganic and organic osmolytes
*#Exit of osmotically obligated water
*#Exit of osmotically obligated water
*A subsequent exposure to hypertonic stress(e.g., correction of [[hyponatremia]] with hypertonic I.V. solution's)resulting from a rapid correction of [[hyponatremia]] causes the [[ions]] to quickly re-enter the [[intracellular space]] and compels the water to follow.<ref name="pmid30357070">{{cite journal| author=Sheikh AB, Afzal RM, Sagheer S, Bukhari MM, Javed A, Nasrullah A et al. z| title=The Dilemma of Inadvertent Pontine Demyelinosis: A Review of Literature. | journal=Cureus | year= 2018 | volume= 10 | issue= 8 | pages= e3174 | pmid=30357070 | doi=10.7759/cureus.3174 | pmc=6197531 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30357070  }} </ref>
*A subsequent exposure to hypertonic stress(e.g., correction of [[hyponatremia]] with hypertonic I.V. solution's)resulting from a rapid correction of [[hyponatremia]] causes the [[ions]] to quickly re-enter the intracellular space and compels the water to follow.<ref name="pmid30357070">{{cite journal| author=Sheikh AB, Afzal RM, Sagheer S, Bukhari MM, Javed A, Nasrullah A et al. z| title=The Dilemma of Inadvertent Pontine Demyelinosis: A Review of Literature. | journal=Cureus | year= 2018 | volume= 10 | issue= 8 | pages= e3174 | pmid=30357070 | doi=10.7759/cureus.3174 | pmc=6197531 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30357070  }} </ref><ref name="pmid23760391" /><ref name="pmid24682140" />
*If the serum sodium levels rise too rapidly, the increased [[Extracellular|extracellular tonicity]] will continue to drive water out of the brain neurons because the brain cells do not have enough time to bring [[Extracellular|extracellular sudiom]] into the cell, so the water will go out very fast instead.<ref name="pmid23760391">{{cite journal| author=Khosya S, Meena H| title=Central pontine myelinolysis. | journal=Indian J Med Res | year= 2013 | volume= 137 | issue= 5 | pages= 993-4 | pmid=23760391 | doi= | pmc=3734697 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23760391  }} </ref>
*If the serum sodium levels rise too rapidly, the increased [[Extracellular|extracellular tonicity]] will continue to drive water out of the brain neurons because the brain cells do not have enough time to bring [[Extracellular|extracellular sudiom]] into the cell, so the water goes out very fast instead.<ref name="pmid23760391">{{cite journal| author=Khosya S, Meena H| title=Central pontine myelinolysis. | journal=Indian J Med Res | year= 2013 | volume= 137 | issue= 5 | pages= 993-4 | pmid=23760391 | doi= | pmc=3734697 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23760391  }} </ref><ref name="pmid24682140" />
*This can lead to cellular dysfunction and death and finally central pontine myelinolysis.<ref name="pmid23760391">{{cite journal| author=Khosya S, Meena H| title=Central pontine myelinolysis. | journal=Indian J Med Res | year= 2013 | volume= 137 | issue= 5 | pages= 993-4 | pmid=23760391 | doi= | pmc=3734697 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23760391  }} </ref>
*This can lead to cellular dysfunction and central pontine myelinolysis and finally death.<ref name="pmid23760391">{{cite journal| author=Khosya S, Meena H| title=Central pontine myelinolysis. | journal=Indian J Med Res | year= 2013 | volume= 137 | issue= 5 | pages= 993-4 | pmid=23760391 | doi= | pmc=3734697 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23760391  }} </ref><ref name="pmid24682140" />


==Genetics==
==Genetics==
Line 23: Line 23:


==Gross Pathology==
==Gross Pathology==
On gross pathology of patients with central pontine myelinolysis a red, central, triangular region of softening may be seen with preservation of the surrounding [[parenchyma]] on opened sagittally [[pons]] and [[Medulla oblongata|medulla]] from the ventral aspect.<ref name="pmid29177819">{{cite journal| author=Haynes HR, Gallagher PJ, Cordaro A, Likeman M, Love S| title=A case of chronic asymptomatic central pontine myelinolysis with histological evidence of remyelination. | journal=Forensic Sci Med Pathol | year= 2018 | volume= 14 | issue= 1 | pages= 106-108 | pmid=29177819 | doi=10.1007/s12024-017-9933-y | pmc=5830465 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29177819  }} </ref>
 
* On gross pathology of patients with central pontine myelinolysis a red, central, triangular region of softening may be seen with preservation of the surrounding [[parenchyma]] on opened sagittally [[pons]] and [[Medulla oblongata|medulla]] from the ventral aspect.<ref name="pmid29177819">{{cite journal| author=Haynes HR, Gallagher PJ, Cordaro A, Likeman M, Love S| title=A case of chronic asymptomatic central pontine myelinolysis with histological evidence of remyelination. | journal=Forensic Sci Med Pathol | year= 2018 | volume= 14 | issue= 1 | pages= 106-108 | pmid=29177819 | doi=10.1007/s12024-017-9933-y | pmc=5830465 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29177819  }} </ref>
*Central and symetrical [[demyelination]] in the base of the [[pons]] in cross section samples<ref name="pmid24887055">{{cite journal| author=Robinson CA, Adiele RC, Tham M, Lucchinetti CF, Popescu BF| title=Early and widespread injury of astrocytes in the absence of demyelination in acute haemorrhagic leukoencephalitis. | journal=Acta Neuropathol Commun | year= 2014 | volume= 2 | issue=  | pages= 52 | pmid=24887055 | doi=10.1186/2051-5960-2-52 | pmc=4035095 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24887055  }} </ref>
 
<br />


==Microscopic Pathology==
==Microscopic Pathology==
On microscopic histopathological analysis, the following features are characteristic findings of central pontine myelinolysis:<ref name="pmid17071802">{{cite journal| author=Love S| title=Demyelinating diseases. | journal=J Clin Pathol | year= 2006 | volume= 59 | issue= 11 | pages= 1151-9 | pmid=17071802 | doi=10.1136/jcp.2005.031195 | pmc=1860500 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17071802  }} </ref>
On microscopic histopathological analysis, the following features are characteristic findings of central pontine myelinolysis:<ref name="pmid17071802">{{cite journal| author=Love S| title=Demyelinating diseases. | journal=J Clin Pathol | year= 2006 | volume= 59 | issue= 11 | pages= 1151-9 | pmid=17071802 | doi=10.1136/jcp.2005.031195 | pmc=1860500 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17071802 }} </ref><ref name="pmid24887055">{{cite journal| author=Robinson CA, Adiele RC, Tham M, Lucchinetti CF, Popescu BF| title=Early and widespread injury of astrocytes in the absence of demyelination in acute haemorrhagic leukoencephalitis. | journal=Acta Neuropathol Commun | year= 2014 | volume= 2 | issue=  | pages= 52 | pmid=24887055 | doi=10.1186/2051-5960-2-52 | pmc=4035095 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24887055 }} </ref>
*
*


Loss of myelinated fibers at the base of the pons that is usually central and symmetrical but also can be neither.
* Loss of myelinated fibers at the base of the pons that is usually central and symmetrical but also can be neither
 
*The lesions are sharply demarcated and contain sheets of lipid‐laden [[Macrophage|macrophages]] and large numbers of reactive [[Astrocyte|astrocytes]].
*Infiltration by [[Lymphocyte|lymphocytes]] is sparse or absent.
*Axons and neurons are mostly well preserved.
*Symmetrically spared “islands” of [[myelinated]] [[white matter]]
 
<br />


==References==
==References==

Revision as of 05:02, 6 May 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Syed Musadiq Ali M.B.B.S.[2], Mohamadmostafa Jahansouz M.D.[3]

Overview

It is understood that central pontine myelinolysis is caused by the rapid correction of hyponatremia. The CNS is particularly susceptible to reductions in plasma osmolarity, specially during hyponatremia which is the most commonly encountered electrolyte disturbance. When a decrease in the plasma osmolarity happens, neural cells first swell but then they are able to regain their original volume through the release of inorganic and organic osmolytes and exit of osmotically obligated water. Subsequent exposure to hypertonic stress(e.g., correction of hyponatremia with hypertonic I.V. solutions)resulting from a rapid correction of hyponatremia causes the ions to quickly re-enter the intracellular space and compels the water to follow. If the serum sodium levels rise too rapidly, the increased extracellular tonicity will continue to drive water out of the brain's cells because the brain cells do not have enough time to bring extracellular sodium into the cell, so the water goes out very fast. This can lead to cellular dysfunction and central pontine myelinolysis and finally death.

Pathophysiology

Pathogenesis

  • It is understood that central pontine myelinolysis is caused by rapid correction of hyponatremia.[1][2]
  • The CNS is particularly susceptible to reductions in plasma osmolarity, specially during hyponatremia which is the most commonly encountered electrolyte disturbance.
  • When a decrease in the plasma osmolarity happens, neural cells first swell but then they are able to regain their original volume through the:[2][3]
    1. Release of inorganic and organic osmolytes
    2. Exit of osmotically obligated water
  • A subsequent exposure to hypertonic stress(e.g., correction of hyponatremia with hypertonic I.V. solution's)resulting from a rapid correction of hyponatremia causes the ions to quickly re-enter the intracellular space and compels the water to follow.[4][2][1]
  • If the serum sodium levels rise too rapidly, the increased extracellular tonicity will continue to drive water out of the brain neurons because the brain cells do not have enough time to bring extracellular sudiom into the cell, so the water goes out very fast instead.[2][1]
  • This can lead to cellular dysfunction and central pontine myelinolysis and finally death.[2][1]

Genetics

There is no association between central pontine myelinolysis and genetic factors.

Gross Pathology

  • On gross pathology of patients with central pontine myelinolysis a red, central, triangular region of softening may be seen with preservation of the surrounding parenchyma on opened sagittally pons and medulla from the ventral aspect.[5]
  • Central and symetrical demyelination in the base of the pons in cross section samples[6]


Microscopic Pathology

On microscopic histopathological analysis, the following features are characteristic findings of central pontine myelinolysis:[7][6]

  • Loss of myelinated fibers at the base of the pons that is usually central and symmetrical but also can be neither
  • The lesions are sharply demarcated and contain sheets of lipid‐laden macrophages and large numbers of reactive astrocytes.
  • Infiltration by lymphocytes is sparse or absent.
  • Axons and neurons are mostly well preserved.
  • Symmetrically spared “islands” of myelinated white matter


References

  1. 1.0 1.1 1.2 1.3 Mascarenhas JV, Jude EB (2014). "Central pontine myelinolysis: electrolytes and beyond". BMJ Case Rep. 2014. doi:10.1136/bcr-2013-203516. PMC 3975522. PMID 24682140.
  2. 2.0 2.1 2.2 2.3 2.4 Khosya S, Meena H (2013). "Central pontine myelinolysis". Indian J Med Res. 137 (5): 993–4. PMC 3734697. PMID 23760391.
  3. Burg MB, Ferraris JD (2008) Intracellular organic osmolytes: function and regulation. J Biol Chem 283 (12):7309-13. DOI:10.1074/jbc.R700042200 PMID: 18256030
  4. Sheikh AB, Afzal RM, Sagheer S, Bukhari MM, Javed A, Nasrullah A et al. z (2018). "The Dilemma of Inadvertent Pontine Demyelinosis: A Review of Literature". Cureus. 10 (8): e3174. doi:10.7759/cureus.3174. PMC 6197531. PMID 30357070.
  5. Haynes HR, Gallagher PJ, Cordaro A, Likeman M, Love S (2018). "A case of chronic asymptomatic central pontine myelinolysis with histological evidence of remyelination". Forensic Sci Med Pathol. 14 (1): 106–108. doi:10.1007/s12024-017-9933-y. PMC 5830465. PMID 29177819.
  6. 6.0 6.1 Robinson CA, Adiele RC, Tham M, Lucchinetti CF, Popescu BF (2014). "Early and widespread injury of astrocytes in the absence of demyelination in acute haemorrhagic leukoencephalitis". Acta Neuropathol Commun. 2: 52. doi:10.1186/2051-5960-2-52. PMC 4035095. PMID 24887055.
  7. Love S (2006). "Demyelinating diseases". J Clin Pathol. 59 (11): 1151–9. doi:10.1136/jcp.2005.031195. PMC 1860500. PMID 17071802.

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