Central pontine myelinolysis history and symptoms

Jump to navigation Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Central pontine myelinolysis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Central pontine myelinolysis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Central pontine myelinolysis history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Central pontine myelinolysis history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Central pontine myelinolysis history and symptoms

CDC on Central pontine myelinolysis history and symptoms

Central pontine myelinolysis history and symptoms in the news

Blogs on Central pontine myelinolysis history and symptoms

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Central pontine myelinolysis history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

Patients with central pontine myelinolysis may have a positive history of: Malnutrition, alcohol use disorder, chronic liver disease, hyperemesis gravidarum, hypophosphatemia secondary to refeeding syndrome and prolonged ischemia. These patients with central pontine myelinolysis most commonly have a history of rapid sodium correction, greater than 0.5-1.0 mEq/L per hour. The most susceptible patients are those with: Chronic hyponatremia (>48 hours), severe hyponatremia (Na <120 mEq/L) and both chronic hyponatremia and severe hyponatremia. Common symptoms of central pontine myelinolysis include: Spastic quadriparesis, dysarthria, pseudobulbar palsy and altered mental status. In some patients, parkinsonian features, behavioral manifestations, and neuropsychological symptoms can also be present: Personality changes, labile affect, disinhibition, poor judgment, paranoid delusions, emotional lability, delirium, hallucinations and catatonia.

History and Symptoms

History

Patients with central pontine myelinolysis may have a positive history of:[1][2][3]

These patients with central pontine myelinolysis most commonly have a history of rapid sodium correction, greater than 0.5-1.0 mEq/L per hour.

The most susceptible patients are those with:[1]

Common Symptoms

Common symptoms of central pontine myelinolysis include:[1][2][3][4]

In some patients, parkinsonian features, behavioral manifestations, and neuropsychological symptoms can also be present:[4][5]

References

  1. 1.0 1.1 1.2 "StatPearls". 2019. PMID 31869161.
  2. 2.0 2.1 Seliger S, Kestenbaum B (2018). "Commentary on Treatment of Severe Hyponatremia". Clin J Am Soc Nephrol. 13 (4): 650–651. doi:10.2215/CJN.13381217. PMC 5969468. PMID 29295827.
  3. 3.0 3.1 Yu J, Zheng SS, Liang TB, Shen Y, Wang WL, Ke QH (2004). "Possible causes of central pontine myelinolysis after liver transplantation". World J Gastroenterol. 10 (17): 2540–3. doi:10.3748/wjg.v10.i17.2540. PMC 4572157. PMID 15300900.
  4. 4.0 4.1 Gopal M, Parasram M, Patel H, Ilorah C, Nersesyan H (2017). "Acute Psychosis as Main Manifestation of Central Pontine Myelinolysis". Case Rep Neurol Med. 2017: 1471096. doi:10.1155/2017/1471096. PMC 5368399. PMID 28392953.
  5. Post B, van Gool WA, Tijssen MA (2009). "Transient Parkinsonism in isolated extrapontine myelinolysis". Neurol Sci. 30 (4): 325–8. doi:10.1007/s10072-009-0088-9. PMC 2707857. PMID 19444382.

Template:WH Template:WS