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{{Celiac disease}}
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==Overview==
==Overview==
==Screening and case finding==
Screening with [[tissue transglutaminase]] (tTG) IgA test is recommended for symptomatic high risk celiac disease patients.
There is significant debate as to the benefits of [[Screening (medicine)|screening]]. Some studies suggest that early detection would decrease the risk of osteoporosis and anaemia. In contrast, a [[cohort study|cohort studied]] in Cambridge suggested that people with undetected coeliac disease had a beneficial risk profile for [[cardiovascular disease]] (less [[overweight]], lower [[cholesterol]] levels).


Due to its high sensitivity, [[serology]] has been proposed as a screening measure, because the presence of antibodies would detect previously undiagnosed cases of coeliac disease and prevent its complications in those patients. Serology may also be used to monitor adherence to diet: in those who still ingest gluten, antibody levels remain elevated.
==Screening==
*Screening in asymptomatic celiac disease patients is not recommended.<ref name="pmid28350935">{{cite journal |vauthors=Chou R, Bougatsos C, Blazina I, Mackey K, Grusing S, Selph S |title=Screening for Celiac Disease: Evidence Report and Systematic Review for the US Preventive Services Task Force |journal=JAMA |volume=317 |issue=12 |pages=1258–1268 |year=2017 |pmid=28350935 |doi=10.1001/jama.2016.10395 |url=}}</ref>
*Screening is recommended for symptomatic and high risk patients with positive family history in first and second degree relatives as well as in patients with other [[autoimmune diseases]] such as, [[Diabetes mellitus type 1|type 1 diabetes mellitus]], inflammatory luminal gastrointestinal disorders, [[Down syndrome]], [[Turner syndrome]], [[IgA deficiency]], and [[IgA nephropathy]].<ref name="pmid28350935">{{cite journal |vauthors=Chou R, Bougatsos C, Blazina I, Mackey K, Grusing S, Selph S |title=Screening for Celiac Disease: Evidence Report and Systematic Review for the US Preventive Services Task Force |journal=JAMA |volume=317 |issue=12 |pages=1258–1268 |year=2017 |pmid=28350935 |doi=10.1001/jama.2016.10395 |url=}}</ref>
*Screening method for celiac disease is tissue transglutaminase (tTG) IgA test.


Clinical scenarios in which screening may be justified include type 1 diabetes unexplained iron-deficiency anemia,<ref>{{cite journal |author=Corazza G, Valentini R, Andreani M, D'Anchino M, Leva M, Ginaldi L, De Feudis L, Quaglino D, Gasbarrini G |title=Subclinical coeliac disease is a frequent cause of iron-deficiency anaemia |journal=Scand J Gastroenterol |volume=30 |issue=2 |pages=153–6 |year=1995 |pmid=7732338}}</ref><ref>{{cite journal |author=Ransford R, Hayes M, Palmer M, Hall M |title=A controlled, prospective screening study of celiac disease presenting as iron deficiency anemia |journal=J Clin Gastroenterol |volume=35 |issue=3 |pages=228&ndash;33 |year=2002 |pmid=12192198}}</ref> [[Down's syndrome]], [[Turner's syndrome]], [[irritable bowel syndrome]], [[Lupus erythematosus|lupus]], and autoimmune thyroid disease.<ref>{{cite journal |author=Sjöberg K, Carlsson A |title=Screening for celiac disease can be justified in high-risk groups |journal=Lakartidningen |volume=101 |issue=48 |pages=3912, 3915–6, 3918&ndash;9 |year=2004 |pmid=15631226}}</ref>
==References==


==Refernces==
{{Reflist|2}}
{{reflist|2}}


{{WH}}
{{WH}}
{{WS}}
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[[Category:Gastroenterology]]
[[Category:Rheumatology]]
[[Category:Autoimmune diseases]]
[[Category:Genetic disorders]]
[[Category:Malnutrition]]
[[Category:Pediatrics]]
[[Category:Dermatology]]
[[Category:Up-To-Date]]

Latest revision as of 20:51, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2]

Overview

Screening with tissue transglutaminase (tTG) IgA test is recommended for symptomatic high risk celiac disease patients.

Screening

References

  1. ↑ 1.0 1.1 Chou R, Bougatsos C, Blazina I, Mackey K, Grusing S, Selph S (2017). "Screening for Celiac Disease: Evidence Report and Systematic Review for the US Preventive Services Task Force". JAMA. 317 (12): 1258–1268. doi:10.1001/jama.2016.10395. PMID 28350935.

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