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{{DrugProjectFormSinglePage
|genericName=generic name
|aOrAn=a
|drugClass=Adrenergic receptor agonist
|indication=a list of indications, separated by commas.
|hasBlackBoxWarning=Yes
|adverseReactions=a list of adverse reactions, separated by commas.
|blackBoxWarningTitle=Warning Title
|blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
|fdaLIADAdult======Condition 1=====


* Dosing Information


{{Chembox new
:* (Dosage)
|   Name = Calcium chloride
 
|   ImageFile = Calcium chloride.jpg
=====Condition 2=====
|   ImageSize = 200px
 
|  ImageName = Calcium chloride
* Dosing Information
|   IUPACName = calcium chloride
 
|  OtherNames = calcium(II) chloride,<br />calcium dichloride
:* (Dosage)
| Section1 = {{Chembox Identifiers
|offLabelAdultGuideSupport======Condition 1=====
|   CASNo = 10043-52-4
 
|   RTECS = EV9800000, anhydrous
* Developed by: (Organisation)
  }}
 
| Section2 = {{Chembox Properties
* Class of Recommendation: (Class) (Link)
|  Formula = CaCl<sub>2</sub><br />CaCl<sub>2</sub>.2H<sub>2</sub>O [Dihydrate]<br />CaCl<sub>2</sub>.4H<sub>2</sub>O [Tetrahydrate]<br />CaCl<sub>2</sub>.6H<sub>2</sub>O [Hexahydrate]
 
|  MolarMass = 110.99 g/mol, anhydrous<br />147.02 g/mol, dihydrate<br />182.04 g/mol, tetrahydrate<br />219.08 g/mol, hexahydrate
* Strength of Evidence: (Category A/B/C) (Link)
|   Appearance = white or colorless solid
 
|   Density = 2.15 g/cm³, anhydrous<br />0.835 g/cm³, dihydrate<br /> 1.71 g/cm³, hexahydrate
* Dosing Information/Recommendation
|  Solubility = 74.5 g/100 ml (20 °C)
 
|   MeltingPt = 772 °C (anhydrous)
:* (Dosage)
|   BoilingPt = >1600  °C
 
  }}
=====Condition 2=====
| Section3 = {{Chembox Structure
 
|   Coordination = [[octahedral]], 6-coordinate
* Developed by: (Organisation)
|   CrystalStruct = deformed rutile
 
  }}
* Class of Recommendation: (Class) (Link)
| Section7 = {{Chembox Hazards
 
|   EUClass = Irritant ('''Xi''')
* Strength of Evidence: (Category A/B/C) (Link)
|   NFPA-H = 1
 
|   NFPA-F =
* Dosing Information/Recommendation
|   NFPA-R =
 
|   RPhrases = {{R36}}
:* (Dosage)
|   SPhrases = {{S2}}, {{S22}}, {{S24}}
|offLabelAdultNoGuideSupport======Condition 1=====
  }}
 
| Section8 = {{Chembox Related
* Dosing Information
|   OtherAnions = [[calcium fluoride]]<br />[[calcium bromide]]<br />calcium iodide
 
|   OtherCations = [[magnesium chloride]]<br />[[strontium chloride]]
:* (Dosage)
  }}
 
}}
=====Condition 2=====
{{SI}}
 
'''Calcium chloride''' is an [[ion|ionic compound]] of [[calcium]] and [[chlorine]].  It is highly  [[soluble]] in water and it is [[deliquescent]].  It is a [[salt]] that is [[solid]] at room temperature, and it behaves as a typical [[ion]]ic [[halide]]. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in cement.  It can be produced directly from limestone, but large amounts are also produced as a by-product of the Solvay process.  Because of its [[hygroscopic]] nature, it must be kept in tightly-sealed containers.
* Dosing Information
 
:* (Dosage)
 
=====Condition 3=====
 
* Dosing Information
 
:* (Dosage)
|fdaLIADPed======Condition 1=====
 
* Dosing Information
 
:* (Dosage)
 
=====Condition 2=====
 
* Dosing Information
 
:* (Dosage)
|offLabelPedGuideSupport======Condition 1=====
 
* Developed by: (Organisation)
 
* Class of Recommendation: (Class) (Link)
 
* Strength of Evidence: (Category A/B/C) (Link)
 
* Dosing Information/Recommendation
 
:* (Dosage)
 
=====Condition 2=====
 
* Developed by: (Organisation)
 
* Class of Recommendation: (Class) (Link)
 
* Strength of Evidence: (Category A/B/C) (Link)
 
* Dosing Information/Recommendation
 
:* (Dosage)
|offLabelPedNoGuideSupport======Condition 1=====
 
* Dosing Information
 
:* (Dosage)
 
=====Condition 2=====
 
* Dosing Information
 
:* (Dosage)
 
=====Condition 3=====
 
* Dosing Information
 
:* (Dosage)
|contraindications=* Condition 1
* Condition 2
* Condition 3
* Condition 4
* Condition 5
|warnings======Conidition 1=====
 
(Description)
 
|clinicalTrials=======Central Nervous System======
 
: (list/description of adverse reactions)
 
======Cardiovascular======
 
: (list/description of adverse reactions)
 
======Respiratory======
 
: (list/description of adverse reactions)
 
======Gastrointestinal======
 
: (list/description of adverse reactions)
 
======Hypersensitive Reactions======
 
: (list/description of adverse reactions)
 
======Miscellaneous======
 
: (list/description of adverse reactions)
 
=====Condition 2=====
 
======Central Nervous System======
 
: (list/description of adverse reactions)
 
======Cardiovascular======
 
: (list/description of adverse reactions)
 
======Respiratory======
 
: (list/description of adverse reactions)
 
======Gastrointestinal======
 
: (list/description of adverse reactions)
 
======Hypersensitive Reactions======
 
: (list/description of adverse reactions)
 
======Miscellaneous======
 
: (list/description of adverse reactions)
|postmarketing=(Description)
|drugInteractions=* Drug 1
* Drug 2
* Drug 3
* Drug 4
* Drug 5
 
=====Drug 1=====
 
(Description)
 
=====Drug 2=====
 
(Description)
 
=====Drug 3=====
 
(Description)
 
=====Drug 4=====
 
(Description)
 
=====Drug 5=====
 
(Description)
|useInPregnancyFDA=(Description)
|useInPregnancyAUS=(Description)
|useInLaborDelivery=(Description)
|useInNursing=(Description)
|useInPed=(Description)
|useInGeri=(Description)
|useInGender=(Description)
|useInRace=(Description)
|useInRenalImpair=(Description)
|useInHepaticImpair=(Description)
|useInReproPotential=(Description)
|useInImmunocomp=(Description)
|othersTitle=Others
|useInOthers=(Description)
 
|administration=(Oral/Intravenous/etc)
|monitoring======Condition 1=====
 
(Description regarding monitoring, from ''Warnings'' section)
 
=====Condition 2=====
 
(Description regarding monitoring, from ''Warnings'' section)
 
=====Condition 3=====
 
(Description regarding monitoring, from ''Warnings'' section)
|IVCompat====Solution===
 
====Compatible====
 
* Solution 1
* Solution 2
* Solution 3
 
====Not Tested====
 
* Solution 1
* Solution 2
* Solution 3
 
====Variable====
 
* Solution 1
* Solution 2
* Solution 3
 
====Incompatible====
 
* Solution 1
* Solution 2
* Solution 3
 
===Y-Site===
 
====Compatible====
 
* Solution 1
* Solution 2
* Solution 3
 
====Not Tested====
 
* Solution 1
* Solution 2
* Solution 3
 
====Variable====
 
* Solution 1
* Solution 2
* Solution 3
 
====Incompatible====
 
* Solution 1
* Solution 2
* Solution 3
 
===Admixture===
 
====Compatible====
 
* Solution 1
* Solution 2
* Solution 3
 
====Not Tested====
 
* Solution 1
* Solution 2
* Solution 3
 
====Variable====
 
* Solution 1
* Solution 2
* Solution 3
 
====Incompatible====
 
* Solution 1
* Solution 2
* Solution 3
 
===Syringe===
 
====Compatible====
 
* Solution 1
* Solution 2
* Solution 3
 
====Not Tested====
 
* Solution 1
* Solution 2
* Solution 3
 
====Variable====
 
* Solution 1
* Solution 2
* Solution 3
 
====Incompatible====
 
* Solution 1
* Solution 2
* Solution 3
 
===TPN/TNA===
 
====Compatible====
 
* Solution 1
* Solution 2
* Solution 3
 
====Not Tested====
 
* Solution 1
* Solution 2
* Solution 3
 
====Variable====
 
* Solution 1
* Solution 2
* Solution 3
 
====Incompatible====


==Chemical properties==
* Solution 1
Calcium chloride can serve as a source of calcium [[ions]] in [[solution]], for instance for [[Precipitation (chemistry)|precipitation]] because many calcium [[Chemical compound|compounds]] are [[insoluble]]:
* Solution 2
* Solution 3
|overdose====Acute Overdose===


3 CaCl<sub>2</sub>([[Aqueous solution|aq]])  +  2 potassium phosphate|K<sub>3</sub>PO<sub>4</sub>([[Aqueous solution|aq]])  →  [[calcium phosphate|Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>]]([[solid|s]])  +  6 [[potassium chloride|KCl]]([[Aqueous solution|aq]])
====Signs and Symptoms====


Molten CaCl<sub>2</sub> can be [[electrolysis|electrolysed]] to give [[calcium]] metal:<br />
(Description)


CaCl<sub>2</sub>([[liquid|l]])  →  Ca([[solid|s]])  +  Cl<sub>2</sub>([[gas|g]])
====Management====


==Preparation==
(Description)
Calcium chloride is a by-product of the Solvay process used for the manufacture of [[sodium carbonate]].  It can also be produced by the action of [[hydrochloric acid]] on [[calcium carbonate]].


[[Calcium carbonate|CaCO<sub>3</sub>]]([[solid|s]])  +  2 [[hydrochloric acid|HCl]] →  CaCl<sub>2</sub>([[Aqueous solution|aq]])  +  [[water (molecule)|H<sub>2</sub>O]]([[liquid|l]])  +  [[carbon dioxide|CO<sub>2</sub>]]([[gas|g]])
===Chronic Overdose===


==Uses==
====Signs and Symptoms====
Millions of tonnes of '''calcium chloride''' are made each year in the US alone, and it has a variety of applications:


* Aqueous Calcium Chloride is used in genetic [[Transformation (genetics)|transformation]] of cells by increasing the cell membrane permeability. This allows DNA fragments to enter the cell more readily.
(Description)


* It is used in [[Glacéau|Smartwater]] and some sports drinks as an [[Electrolyte]]
====Management====


* It is used in Emergency Medicine to treat Calcium Channel Blocker toxicity with overdoses of drugs such as [[Cardizem]]. It is also used to treat certain electrolyte imbalances along with Calcium Gluconate.
(Description)
|drugBox={{Drugbox2
| verifiedrevid =
| IUPAC_name =
| image =
| drug_name =


* It is also used to induce competence for DNA uptake in experiments involving uptake of DNA from outside the cell
<!--Clinical data-->
| tradename =
| MedlinePlus =
| licence_US =
| pregnancy_AU =
| pregnancy_US =
| legal_status =
| routes_of_administration =


==Precautions==
<!--Pharmacokinetic data-->
Calcium chloride is an irritant; wear gloves and goggles to protect hands and eyes; avoid inhalation.
| bioavailability =  
| metabolism =  
| elimination_half-life =  
| excretion =  


Although calcium chloride is relatively safe to handle, care should be taken that it is not ingested. Calcium chloride reacts [[exothermic reaction|exothermically]] with water and can burn the mouth and [[esophagus]].
<!--Identifiers-->
| CAS_number_Ref =
| CAS_number =
| ATC_prefix =
| ATC_suffix =
| PubChem =
| IUPHAR_ligand =
| DrugBank_Ref =
| DrugBank =
| ChemSpiderID_Ref =
| ChemSpiderID =
| UNII_Ref =
| UNII =
| KEGG_Ref =
| KEGG =
| ChEBI_Ref =
| ChEBI =
| ChEMBL_Ref =
| ChEMBL =


==References==
<!--Chemical data-->
<references/>
| C= | H= | N= | O=  
==General references==
| molecular_weight =  
* {{Greenwood&Earnshaw}}
| smiles =  
* ''Handbook of Chemistry and Physics'', 71st edition, CRC Press, Ann Arbor, Michigan, 1990.
| InChI =
| InChIKey =
| StdInChI_Ref =  
| StdInChI =  
| StdInChIKey_Ref =  
| StdInChIKey =
| melting_point =  
}}
|mechAction=(Description)
|structure=(Description with picture)
|PD=(Description)
|PK=(Description)
|nonClinToxic=(Description)
|clinicalStudies======Condition 1=====


==External links==
(Description)
* [http://www.ilo.org/public/english/protection/safework/cis/products/icsc/dtasht/_icsc11/icsc1184.htm International Chemical Safety Card 1184]
* [http://www.dow.com/webapps/lit/litorder.asp?filepath=calcium/pdfs/noreg/173-01534.pdf&pdf=true Calcium Chloride Handbook from Dow Chemical (pdf 1.6MB)]
* [http://wwwprod.dot.state.fl.us/research-center/Completed_Proj/Summary_SMO/FDOT_806_rpt.pdf Report on steel corrosion by chloride including CaCl<sub>2</sub>]


{{Mineral supplements}}
=====Condition 2=====
{{Urologicals}}


[[Category:Calcium compounds]]
(Description)
[[Category:Chlorides]]
[[Category:Metal halides]]
[[Category:Deliquescent substances]]
[[Category:Desiccants]]
[[Category:Endocrinology]]


[[da:Kalciumklorid]]
=====Condition 3=====
[[de:Calciumchlorid]]
[[es:Cloruro cálcico]]
[[fr:Chlorure de calcium]]
[[gl:Cloruro de calcio]]
[[it:Cloruro di calcio]]
[[hu:Kalcium-klorid]]
[[nl:Calciumchloride]]
[[ja:塩化カルシウム]]
[[pl:Chlorek wapnia]]
[[pt:Cloreto de cálcio]]
[[ru:Хлорид кальция]]
[[fi:Kalsiumkloridi]]
[[sv:Kalciumklorid]]
[[zh:氯化鈣]]


{{WikiDoc Help Menu}}
(Description)
{{WikiDoc Sources}}
|howSupplied=(Description)
|fdaPatientInfo=(Patient Counseling Information)
|nlmPatientInfo=(Link to patient information page)
|lookAlike=* (Paired Confused Name 1a) — (Paired Confused Name 1b)
* (Paired Confused Name 2a) — (Paired Confused Name 2b)
* (Paired Confused Name 3a) — (Paired Confused Name 3b)
|drugShortage=Drug Shortage
}}

Revision as of 19:35, 18 December 2014

Calcium chloride
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

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Black Box Warning

Warning Title
See full prescribing information for complete Boxed Warning.
Condition Name: (Content)

Overview

Calcium chloride is a Adrenergic receptor agonist that is FDA approved for the {{{indicationType}}} of a list of indications, separated by commas.. There is a Black Box Warning for this drug as shown here. Common adverse reactions include a list of adverse reactions, separated by commas..

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition 1
  • Dosing Information
  • (Dosage)
Condition 2
  • Dosing Information
  • (Dosage)

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition 1
  • Developed by: (Organisation)
  • Class of Recommendation: (Class) (Link)
  • Strength of Evidence: (Category A/B/C) (Link)
  • Dosing Information/Recommendation
  • (Dosage)
Condition 2
  • Developed by: (Organisation)
  • Class of Recommendation: (Class) (Link)
  • Strength of Evidence: (Category A/B/C) (Link)
  • Dosing Information/Recommendation
  • (Dosage)

Non–Guideline-Supported Use

Condition 1
  • Dosing Information
  • (Dosage)
Condition 2
  • Dosing Information
  • (Dosage)
Condition 3
  • Dosing Information
  • (Dosage)

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition 1
  • Dosing Information
  • (Dosage)
Condition 2
  • Dosing Information
  • (Dosage)

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition 1
  • Developed by: (Organisation)
  • Class of Recommendation: (Class) (Link)
  • Strength of Evidence: (Category A/B/C) (Link)
  • Dosing Information/Recommendation
  • (Dosage)
Condition 2
  • Developed by: (Organisation)
  • Class of Recommendation: (Class) (Link)
  • Strength of Evidence: (Category A/B/C) (Link)
  • Dosing Information/Recommendation
  • (Dosage)

Non–Guideline-Supported Use

Condition 1
  • Dosing Information
  • (Dosage)
Condition 2
  • Dosing Information
  • (Dosage)
Condition 3
  • Dosing Information
  • (Dosage)

Contraindications

  • Condition 1
  • Condition 2
  • Condition 3
  • Condition 4
  • Condition 5

Warnings

Warning Title
See full prescribing information for complete Boxed Warning.
Condition Name: (Content)
Conidition 1

(Description)

Adverse Reactions

Clinical Trials Experience

Central Nervous System
(list/description of adverse reactions)
Cardiovascular
(list/description of adverse reactions)
Respiratory
(list/description of adverse reactions)
Gastrointestinal
(list/description of adverse reactions)
Hypersensitive Reactions
(list/description of adverse reactions)
Miscellaneous
(list/description of adverse reactions)
Condition 2
Central Nervous System
(list/description of adverse reactions)
Cardiovascular
(list/description of adverse reactions)
Respiratory
(list/description of adverse reactions)
Gastrointestinal
(list/description of adverse reactions)
Hypersensitive Reactions
(list/description of adverse reactions)
Miscellaneous
(list/description of adverse reactions)

Postmarketing Experience

(Description)

Drug Interactions

  • Drug 1
  • Drug 2
  • Drug 3
  • Drug 4
  • Drug 5
Drug 1

(Description)

Drug 2

(Description)

Drug 3

(Description)

Drug 4

(Description)

Drug 5

(Description)

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): (Description)
Pregnancy Category (AUS): (Description)

Labor and Delivery

(Description)

Nursing Mothers

(Description)

Pediatric Use

(Description)

Geriatic Use

(Description)

Gender

(Description)

Race

(Description)

Renal Impairment

(Description)

Hepatic Impairment

(Description)

Females of Reproductive Potential and Males

(Description)

Immunocompromised Patients

(Description)

Others

(Description)

Administration and Monitoring

Administration

(Oral/Intravenous/etc)

Monitoring

Condition 1

(Description regarding monitoring, from Warnings section)

Condition 2

(Description regarding monitoring, from Warnings section)

Condition 3

(Description regarding monitoring, from Warnings section)

IV Compatibility

Solution

Compatible

  • Solution 1
  • Solution 2
  • Solution 3

Not Tested

  • Solution 1
  • Solution 2
  • Solution 3

Variable

  • Solution 1
  • Solution 2
  • Solution 3

Incompatible

  • Solution 1
  • Solution 2
  • Solution 3

Y-Site

Compatible

  • Solution 1
  • Solution 2
  • Solution 3

Not Tested

  • Solution 1
  • Solution 2
  • Solution 3

Variable

  • Solution 1
  • Solution 2
  • Solution 3

Incompatible

  • Solution 1
  • Solution 2
  • Solution 3

Admixture

Compatible

  • Solution 1
  • Solution 2
  • Solution 3

Not Tested

  • Solution 1
  • Solution 2
  • Solution 3

Variable

  • Solution 1
  • Solution 2
  • Solution 3

Incompatible

  • Solution 1
  • Solution 2
  • Solution 3

Syringe

Compatible

  • Solution 1
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  • Solution 3

Not Tested

  • Solution 1
  • Solution 2
  • Solution 3

Variable

  • Solution 1
  • Solution 2
  • Solution 3

Incompatible

  • Solution 1
  • Solution 2
  • Solution 3

TPN/TNA

Compatible

  • Solution 1
  • Solution 2
  • Solution 3

Not Tested

  • Solution 1
  • Solution 2
  • Solution 3

Variable

  • Solution 1
  • Solution 2
  • Solution 3

Incompatible

  • Solution 1
  • Solution 2
  • Solution 3

Overdosage

Acute Overdose

Signs and Symptoms

(Description)

Management

(Description)

Chronic Overdose

Signs and Symptoms

(Description)

Management

(Description)

Pharmacology

Chemical structure of Calcium chloride
Calcium chloride
Systematic (IUPAC) name
?
Identifiers
CAS number ?
ATC code ?
PubChem ?
Chemical data
Formula ?
Mol. mass ?
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes ?

Mechanism of Action

(Description)

Structure

(Description with picture)

Pharmacodynamics

(Description)

Pharmacokinetics

(Description)

Nonclinical Toxicology

(Description)

Clinical Studies

Condition 1

(Description)

Condition 2

(Description)

Condition 3

(Description)

How Supplied

(Description)

Storage

There is limited information regarding Calcium chloride Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Calcium chloride |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Calcium chloride |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

(Patient Counseling Information)

Precautions with Alcohol

Alcohol-Calcium chloride interaction has not been established. Talk to your doctor regarding the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Calcium chloride Brand Names in the drug label.

Look-Alike Drug Names

  • (Paired Confused Name 1a) — (Paired Confused Name 1b)
  • (Paired Confused Name 2a) — (Paired Confused Name 2b)
  • (Paired Confused Name 3a) — (Paired Confused Name 3b)

Drug Shortage Status

Drug Shortage

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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