CALML5: Difference between revisions

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{{Underlinked|date=May 2016}}
 
{{Infobox_gene}}
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'''Calmodulin-like protein 5''' is a [[protein]] that in humans is encoded by the ''CALML5'' [[gene]].<ref name="pmid10777582">{{cite journal | vauthors = Mehul B, Bernard D, Simonetti L, Bernard MA, Schmidt R | title = Identification and cloning of a new calmodulin-like protein from human epidermis | journal = J Biol Chem | volume = 275 | issue = 17 | pages = 12841–7 |date=Jun 2000 | pmid = 10777582 | pmc =  | doi =10.1074/jbc.275.17.12841 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CALML5 calmodulin-like 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51806| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_CALML5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2b1u.
| PDB = {{PDB2|2b1u}}
| Name = Calmodulin-like 5
| HGNCid = 18180
| Symbol = CALML5
| AltSymbols =; CLSP
| OMIM = 605183
| ECnumber = 
| Homologene = 49485
| MGIid = 1931464
| GeneAtlas_image1 = PBB_GE_CALML5_220414_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008544 |text = epidermis development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51806
    | Hs_Ensembl = ENSG00000178372
    | Hs_RefseqProtein = NP_059118
    | Hs_RefseqmRNA = NM_017422
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 5530660
    | Hs_GenLoc_end = 5531518
    | Hs_Uniprot = Q9NZT1
    | Mm_EntrezGene = 80796
    | Mm_Ensembl = ENSMUSG00000033765
    | Mm_RefseqmRNA = NM_020036
    | Mm_RefseqProtein = NP_064420
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 3837002
    | Mm_GenLoc_end = 3837917
    | Mm_Uniprot = Q6WEH7
  }}
}}
'''Calmodulin-like 5''', also known as '''CALML5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CALML5 calmodulin-like 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51806| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.<ref name="entrez">{{cite web | title = Entrez Gene: CALML5 calmodulin-like 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51806| accessdate = }}</ref>
| summary_text = This gene encodes a novel calcium binding protein expressed in the epidermis and related to the [[Calmodulin|calmodulin]] family of [[Calcium-binding_protein|calcium binding proteins]]. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating [[Keratinocyte|keratinocytes]]. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CALML5}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
*{{cite journal  | author=Méhul B, Bernard D, Simonetti L, ''et al.'' |title=Identification and cloning of a new calmodulin-like protein from human epidermis. |journal=J. Biol. Chem. |volume=275 |issue= 17 |pages= 12841-7 |year= 2000 |pmid= 10777582 |doi= }}
*{{cite journal  | vauthors=Méhul B, Bernard D, Schmidt R |title=Calmodulin-like skin protein: a new marker of keratinocyte differentiation |journal=J. Invest. Dermatol. |volume=116 |issue= 6 |pages= 905–9 |year= 2001 |pmid= 11407979 |doi= 10.1046/j.0022-202x.2001.01376.x }}
*{{cite journal  | author=Méhul B, Bernard D, Schmidt R |title=Calmodulin-like skin protein: a new marker of keratinocyte differentiation. |journal=J. Invest. Dermatol. |volume=116 |issue= 6 |pages= 905-9 |year= 2001 |pmid= 11407979 |doi= 10.1046/j.0022-202x.2001.01376.x }}
*{{cite journal  | vauthors=Durussel I, Méhul B, Bernard D |title=Cation- and peptide-binding properties of human calmodulin-like skin protein |journal=Biochemistry |volume=41 |issue= 17 |pages= 5439–48 |year= 2002 |pmid= 11969404 |doi=10.1021/bi016062z |display-authors=etal}}
*{{cite journal  | author=Durussel I, Méhul B, Bernard D, ''et al.'' |title=Cation- and peptide-binding properties of human calmodulin-like skin protein. |journal=Biochemistry |volume=41 |issue= 17 |pages= 5439-48 |year= 2002 |pmid= 11969404 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Méhul B, Bernard D, Brouard M |title=Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis |journal=Exp. Dermatol. |volume=15 |issue= 6 |pages= 469–77 |year= 2006 |pmid= 16689864 |doi= 10.1111/j.1600-0625.2006.00433.x |display-authors=etal}}
*{{cite journal  | author=Méhul B, Bernard D, Brouard M, ''et al.'' |title=Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis. |journal=Exp. Dermatol. |volume=15 |issue= 6 |pages= 469-77 |year= 2006 |pmid= 16689864 |doi= 10.1111/j.1600-0625.2006.00433.x }}
*{{cite journal  | vauthors=Babini E, Bertini I, Capozzi F |title=A structural and dynamic characterization of the EF-hand protein CLSP |journal=Structure |volume=14 |issue= 6 |pages= 1029–38 |year= 2006 |pmid= 16765896 |doi= 10.1016/j.str.2006.04.004 |display-authors=etal}}
*{{cite journal  | author=Babini E, Bertini I, Capozzi F, ''et al.'' |title=A structural and dynamic characterization of the EF-hand protein CLSP. |journal=Structure |volume=14 |issue= 6 |pages= 1029-38 |year= 2006 |pmid= 16765896 |doi= 10.1016/j.str.2006.04.004 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=51806}}
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{{gene-10-stub}}


{{WH}}
[[Category:EF-hand-containing proteins]]
{{WS}}

Latest revision as of 09:10, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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n/a

Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Calmodulin-like protein 5 is a protein that in humans is encoded by the CALML5 gene.[1][2]

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.[2]

References

  1. ↑ Mehul B, Bernard D, Simonetti L, Bernard MA, Schmidt R (Jun 2000). "Identification and cloning of a new calmodulin-like protein from human epidermis". J Biol Chem. 275 (17): 12841–7. doi:10.1074/jbc.275.17.12841. PMID 10777582.
  2. ↑ 2.0 2.1 "Entrez Gene: CALML5 calmodulin-like 5".

External links

Further reading



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