Bronchiolitis obliterans
| Bronchiolitis obliterans | |
| DiseasesDB | 1704 |
|---|---|
| MeSH | D001989 |
Editor-in-Chief: Kaochoy Saechao, MD, MPH
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Overview
Bronchiolitis obliterans, Popcorn Workers' Lung or Diacetyl-induced Bronchiolitis Obliterans - DiBO, is a rare disease of the lung wherein the bronchioles are obliterated with fibrotic tissue.
Etiology
Bronchiolitis obliterans has many possible causes, including: collagen vascular disease, transplant rejection in organ transplant patients, viral infection (RSV, adenovirus, PCP, HIV, CMV), drug reaction, aspiration and complications of prematurity (bronchopulmonary dysplasia), and exposure to toxic fumes, including: diacetyl, sulfur dioxide, nitrogen dioxide, ammonia, chlorine, thionyl chloride, methyl isocyanate, hydrogen fluoride, hydrogen bromide, hydrogen chloride, hydrogen sulfide, phosgene, polyamide-amine dyes, and ozone. Additionally, the disorder may be idiopathic (without known cause). [1][2][5]
Presentation
Bronchiolitis obliterans is a lung disease characterized by a fixed airway obstruction. Inflammation and scarring occur in the airways of the lung, resulting in shortness of breath and dry cough.
Diagnosis
Bronchiolitis obliterans patients should be seen by a board-certified Pulmonologist for accurate diagnosis.
Prognosis/treatment
This disease is irreversible and severe cases often require a lung transplant. Evaluation of interventions to prevent bronchiolitis obliterans relies on early detection of abnormal spirometry results or unusual decreases in repeated measurements.
Industrial inhalants
There is no consensus classification scheme for bronchiolitis subtypes. One author describes four specific subtypes as follows: cellular bronchiolitis, respiratory bronchiolitis, bronchiolitis obliterans and bronchiolitis obliterans with intraluminal polyps (proliferative bronchiolitis obliterans). There are many industrial inhalants that are known to cause bronchiolitis. [5]
Industrial workers who have presented with bronchiolitis:
- nylon-flock workers [6]
- workers who spray prints onto textiles with polyamide-amine dyes [6]
- battery workers who are exposed to thionyl chloride fumes
- workers at plants that use or manufacture flavorings, e.g. diacetyl butter-like flavoring [3][6][7]
See also
External links
- National Institutes of Health: Haz-Map Information on Hazardous Chemicals and Occupational Diseases by Jay A. Brown, M.D., M.P.H. Bronchiolitis obliterans
- National Institute for Occupational Safety and Health (NIOSH) Alert: Preventing lung disease in workers who make or use flavorings
Sources
- Brant & Helms. Fundamentals of Diagnostic Radiology LWW, 1999.
- Webb, et al. High Resolution CT of the Lung. 3rd edition. LWW, 2000.
- Harber, Philip; Saechao, Kaochoy; & Boomus, Catherine. Diacetyl-induced lung Toxicological Reviews 2006;vol 25(4):261-72.
References
- ^ Brant & Helms (1999). Fundamentals of Diagnostic Radiology.
- ^ Webb, et al (2000). High Resolution CT of the Lung, 3rd Edition.
- ^ Center for Disease Control (2002). Fixed obstructive lung disease in workers at a microwave popcorn factory, 7th Edition.
- ^ National Institute for Occupational Safety and Health. Preventing lung disease in workers who make or use flavorings, 2004
- ^ Colby, T.V. "Bronchiolitis, Pathologic Considerations". Am J Clin Pathology 1998;109:101-9
- ^ National Institutes of Health. Haz-Map; Information on Hazardous Chemicals and Occupational Diseases by Jay A. Brown, M.D., M.P.H.
- ^ California Department of Health Services
- ^ E. Neil Schachter. "Popcorn Workers' Lung". New England Journal of Medicine 2002;347(5):360-1.
- ^ David Egilman (2007). "Popcorn Workers Lung"
- ^ "Doctor warns consumers of popcorn fumes", Marcus Kabel, Associated Press, September 5, 2007, hosted by Yahoo! News, retrieved 2007-09-10.
- ^ Letter from Cecile Rose to U.S. Food and Drug Administration, from www.defendingscience.org
- ^ David Michaels (2007). Popcorn Lung Coming to Your Kitchen? The FDA Doesn’t Want to Know, a blog post at thepumphandle.wordpress.com
- ^ Reuters New Report: FDA to probe popcorn link in man's lung disease.
- ^ Weaver Popcorn Company Press Release: "Pop Weaver Introduces First Microwave Popcorn With Flavoring Containing No Diacetyl", 2007-08-27, hosted at PRNewswire.com. "Pop Weaver introduces first microwave popcorn with flavoring containing no diacetyl"PDF.
- ^ USA Today. ConAgra to drop popcorn chemical linked to lung ailment
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| Evidence Based Medicine Regarding Bronchiolitis obliterans | AND (Cochrane Database Syst Rev[http://worldselectshop.com/?id=9361 Cochrane Collaboration on Bronchiolitis obliterans • Bandolier on Bronchiolitis obliterans • TRIP on Bronchiolitis obliterans |
| Cost Effectiveness of Bronchiolitis obliterans | AND (Cost effectiveness) |
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AND (pharmacogenomics)}} Genetics of Bronchiolitis obliterans • AND (pharmacogenomics)}} Pharmacogenomics of Bronchiolitis obliterans • AND (proteomics)}} Proteomics of Bronchiolitis obliterans
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