Brain Stem Gliomas pathophysiology: Difference between revisions

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==Pathophysiology==
==Pathophysiology==
The brain stem gliomas are classified into 4 subtypes, and each has its distinct histological features:<ref>Classification of Brainstem gliomas. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/brainstem-glioma</ref>
The brain stem gliomas are classified into 4 subtypes, and each has its distinct histological features:<ref>Pathophysiology of Brainstem gliomas. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/brainstem-glioma</ref>
*'''Diffuse astrocytoma'''
*'''Diffuse astrocytoma'''
**Usually fibrillary astrocytomas
**Usually fibrillary astrocytomas

Revision as of 18:26, 26 August 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Pathophysiology

The brain stem gliomas are classified into 4 subtypes, and each has its distinct histological features:[1]

  • Diffuse astrocytoma
    • Usually fibrillary astrocytomas
    • WHO grades II-IV
    • Grade does not impact on prognosis, and thus biopsy is usually not necessary
  • Focal glioma
    • Fibrillary astrocytoma (grade II): most common histology
    • Pilocytic astrocytoma
    • Ganglioglioma
  • (Dorsally) exophytic glioma
    • Low grade astrocytoma
    • Ganglioglioma
  • NF1-associated brainstem glioma
    • Seen in up to 9% of NF1 patients
    • Most frequently seen in the medulla
    • Appears similar to a sporadic focal brainstem glioma but has an even better prognosis, with little if any progression

References

  1. Pathophysiology of Brainstem gliomas. Dr Yuranga Weerakkody and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/brainstem-glioma

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