Balsalazide

Balsalazide

Clinical data
Pregnancy category	US: B (No risk in non-human studies)
ATC code	A07EC04 (WHO)
Legal status
Legal status	POM [UK]
Pharmacokinetic data
Bioavailability	<1%
Protein binding	≥99%
Elimination half-life	12hr
Identifiers
IUPAC name 5-[4-(2-carboxyethylcarbamoyl)phenyl]diazenyl-2-hydroxy-benzoic acid
CAS Number	80573-04-2
PubChem CID	5362070
DrugBank	APRD00141
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C17H15N3O6
Molar mass	357.318 g/mol

Overview

Balsalazide is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease. It is sold under the name "Colazal" in the US and "Colazide" in the UK.

The chemical name is (E)-5-[[-4-(2-carboxyethyl) aminocarbonyl] phenyl]azo] -2-hydroxybenzoic acid. It is usually administered as the disodium salt.

Balsalazide releases mesalazine, also known as 5-aminosalicylic acid, or 5-ASA, in the large intestine. Its advantage over that drug in the treatment of Ulcerative colitis is believed to be the delivery of the active agent past the small intestine to the large intestine, the active site of ulcerative colitis.

External links

• FDA Colazal Info
• Colazal Label (PDF)