BCL10

B-cell CLL/lymphoma 10
Identifiers
Symbols	BCL10 ; CARMEN; CIPER; CLAP; c-E10; mE10
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2912
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

B-cell CLL/lymphoma 10, also known as BCL10, is a human gene.

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Further reading

• Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). "Genetic alterations underlying the pathogenesis of MALT lymphoma". Hematol. J. 3 (1): 10–3. doi:10.1038/sj/thj/6200146. PMID 11960389.CS1 maint: Multiple names: authors list (link)
• Lee WC, Balsara B, Liu Z; et al. (1996). "Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma". Cancer Res. 56 (19): 4297–301. PMID 8813110.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Willis TG, Jadayel DM, Du MQ; et al. (1999). "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types". Cell. 96 (1): 35–45. PMID 9989495.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koseki T, Inohara N, Chen S; et al. (1999). "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10". J. Biol. Chem. 274 (15): 9955–61. PMID 10187770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Thome M, Martinon F, Hofmann K; et al. (1999). "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase". J. Biol. Chem. 274 (15): 9962–8. PMID 10187771.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yan M, Lee J, Schilbach S; et al. (1999). "mE10, a novel caspase recruitment domain-containing proapoptotic molecule". J. Biol. Chem. 274 (15): 10287–92. PMID 10187815.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Q, Siebert R, Yan M; et al. (1999). "Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)". Nat. Genet. 22 (1): 63–8. doi:10.1038/8767. PMID 10319863.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srinivasula SM, Ahmad M, Lin JH; et al. (1999). "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis". J. Biol. Chem. 274 (25): 17946–54. PMID 10364242.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Apostolou S, De Rienzo A, Murthy SS; et al. (1999). "Absence of BCL10 mutations in human malignant mesothelioma". Cell. 97 (6): 684–6, discussion 686-8. PMID 10380921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB". J. Biol. Chem. 274 (29): 20127–32. PMID 10400625.CS1 maint: Multiple names: authors list (link)
• Yoneda T, Imaizumi K, Maeda M; et al. (2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. PMID 10753917.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ye H, Dogan A, Karran L; et al. (2000). "BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma". Am. J. Pathol. 157 (4): 1147–54. PMID 11021819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bertin J, Guo Y, Wang L; et al. (2001). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.". J. Biol. Chem. 275 (52): 41082–6. doi:10.1074/jbc.C000726200. PMID 11053425.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uren AG, O'Rourke K, Aravind LA; et al. (2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell. 6 (4): 961–7. PMID 11090634.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Poyet JL, Srinivasula SM, Alnemri ES (2001). "vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma". J. Biol. Chem. 276 (5): 3183–7. doi:10.1074/jbc.C000792200. PMID 11113112.CS1 maint: Multiple names: authors list (link)
• Ruland J, Duncan GS, Elia A; et al. (2001). "Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure". Cell. 104 (1): 33–42. PMID 11163238.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang L, Guo Y, Huang WJ; et al. (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lucas PC, Yonezumi M, Inohara N; et al. (2001). "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway". J. Biol. Chem. 276 (22): 19012–9. doi:10.1074/jbc.M009984200. PMID 11262391.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bertin J, Wang L, Guo Y; et al. (2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gaide O, Martinon F, Micheau O; et al. (2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. PMID 11356195.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)