BCL10: Difference between revisions

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{{Infobox_gene}}
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'''B-cell lymphoma/leukemia 10''' is a [[protein]] that in humans is encoded by the ''BCL10'' [[gene]].<ref name="pmid9989495">{{cite journal | vauthors = Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson PG, Dyer MJ | title = Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types | journal = Cell | volume = 96 | issue = 1 | pages = 35–45 | date = March 1999 | pmid = 9989495 | pmc =  | doi = 10.1016/S0092-8674(00)80957-5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BCL10 B-cell CLL/lymphoma 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8915| accessdate = }}</ref> Like [[BCL2]], [[BCL3]], BCL5, [[BCL6]], BCL7A, and [[BCL9]], it has clinical significance in [[lymphoma]].
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = B-cell CLL/lymphoma 10
| HGNCid = 989
| Symbol = BCL10
| AltSymbols =; CARMEN; CIPER; CLAP; c-E10; mE10
| OMIM = 603517
| ECnumber = 
| Homologene = 2912
| MGIid = 1337994
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0019209 |text = kinase activator activity}} {{GNF_GO|id=GO:0031625 |text = ubiquitin protein ligase binding}} {{GNF_GO|id=GO:0043130 |text = ubiquitin binding}} {{GNF_GO|id=GO:0043422 |text = protein kinase B binding}} {{GNF_GO|id=GO:0043621 |text = protein self-association}} {{GNF_GO|id=GO:0051059 |text = NF-kappaB binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0032449 |text = CBM complex}} {{GNF_GO|id=GO:0042101 |text = T cell receptor complex}} {{GNF_GO|id=GO:0045121 |text = lipid raft}} {{GNF_GO|id=GO:0046696 |text = lipopolysaccharide receptor complex}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0002224 |text = toll-like receptor signaling pathway}} {{GNF_GO|id=GO:0002237 |text = response to molecule of bacterial origin}} {{GNF_GO|id=GO:0002250 |text = adaptive immune response}} {{GNF_GO|id=GO:0002906 |text = negative regulation of mature B cell apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007249 |text = I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0008219 |text = cell death}} {{GNF_GO|id=GO:0016064 |text = immunoglobulin mediated immune response}} {{GNF_GO|id=GO:0031398 |text = positive regulation of protein ubiquitination}} {{GNF_GO|id=GO:0032765 |text = positive regulation of mast cell cytokine production}} {{GNF_GO|id=GO:0042109 |text = lymphotoxin A biosynthetic process}} {{GNF_GO|id=GO:0042221 |text = response to chemical stimulus}} {{GNF_GO|id=GO:0042226 |text = interleukin-6 biosynthetic process}} {{GNF_GO|id=GO:0042327 |text = positive regulation of phosphorylation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0045087 |text = innate immune response}} {{GNF_GO|id=GO:0045416 |text = positive regulation of interleukin-8 biosynthetic process}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0050852 |text = T cell receptor signaling pathway}} {{GNF_GO|id=GO:0051092 |text = activation of NF-kappaB transcription factor}} {{GNF_GO|id=GO:0051260 |text = protein homooligomerization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8915
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_003912
    | Hs_RefseqmRNA = NM_003921
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 12042
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_009740
    | Mm_RefseqProtein = NP_033870
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''B-cell CLL/lymphoma 10''', also known as '''BCL10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BCL10 B-cell CLL/lymphoma 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8915| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene was identified by its translocation in a case of [[mucosa-associated lymphoid tissue (MALT) lymphoma]]. The protein encoded by this gene contains a [[CARD domain|caspase recruitment domain (CARD)]], and has been shown to induce apoptosis and to activate [[NF-kappaB]]. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with the [[paracaspase]] [[MALT1]], a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.<ref name="entrez"/> Bcl10 has been shown to be functionally conserved all the way back to [[zebrafish]]. <ref name = pmid25849213>{{cite journal | vauthors =  Mazzone P, Scudiero I, Ferravante A, Paolucci M, D'Andrea LE, Varricchio E, Telesio G, De Maio C, Pizzulo M, Zotti T, Reale C, Vito P, Stilo R| title = Functional characterization of zebrafish. (Danio rerio) Bcl10 | journal = PLOS ONE | volume = 10 | issue = 4 | pages = e0122365 | date = April 2015 | pmid = 25849213 | doi = 10.1371/journal.pone.0122365 | pmc=4388727}}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.<ref name="entrez">{{cite web | title = Entrez Gene: BCL10 B-cell CLL/lymphoma 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8915| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Bertoni F, Cavalli F, Cotter FE, Zucca E |title=Genetic alterations underlying the pathogenesis of MALT lymphoma. |journal=Hematol. J. |volume=3 |issue= 1 |pages= 10-3 |year= 2003 |pmid= 11960389 |doi= 10.1038/sj/thj/6200146 }}
*{{cite journal  | author=Lee WC, Balsara B, Liu Z, ''et al.'' |title=Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma. |journal=Cancer Res. |volume=56 |issue= 19 |pages= 4297-301 |year= 1996 |pmid= 8813110 |doi=  }}
*{{cite journal  | author=Willis TG, Jadayel DM, Du MQ, ''et al.'' |title=Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. |journal=Cell |volume=96 |issue= 1 |pages= 35-45 |year= 1999 |pmid= 9989495 |doi=  }}
*{{cite journal  | author=Koseki T, Inohara N, Chen S, ''et al.'' |title=CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 9955-61 |year= 1999 |pmid= 10187770 |doi=  }}
*{{cite journal  | author=Thome M, Martinon F, Hofmann K, ''et al.'' |title=Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 9962-8 |year= 1999 |pmid= 10187771 |doi=  }}
*{{cite journal  | author=Yan M, Lee J, Schilbach S, ''et al.'' |title=mE10, a novel caspase recruitment domain-containing proapoptotic molecule. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10287-92 |year= 1999 |pmid= 10187815 |doi=  }}
*{{cite journal  | author=Zhang Q, Siebert R, Yan M, ''et al.'' |title=Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32). |journal=Nat. Genet. |volume=22 |issue= 1 |pages= 63-8 |year= 1999 |pmid= 10319863 |doi= 10.1038/8767 }}
*{{cite journal  | author=Srinivasula SM, Ahmad M, Lin JH, ''et al.'' |title=CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17946-54 |year= 1999 |pmid= 10364242 |doi=  }}
*{{cite journal  | author=Apostolou S, De Rienzo A, Murthy SS, ''et al.'' |title=Absence of BCL10 mutations in human malignant mesothelioma. |journal=Cell |volume=97 |issue= 6 |pages= 684-6; discussion 686-8 |year= 1999 |pmid= 10380921 |doi=  }}
*{{cite journal  | author=Costanzo A, Guiet C, Vito P |title=c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20127-32 |year= 1999 |pmid= 10400625 |doi=  }}
*{{cite journal  | author=Yoneda T, Imaizumi K, Maeda M, ''et al.'' |title=Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11114-20 |year= 2000 |pmid= 10753917 |doi=  }}
*{{cite journal  | author=Ye H, Dogan A, Karran L, ''et al.'' |title=BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. |journal=Am. J. Pathol. |volume=157 |issue= 4 |pages= 1147-54 |year= 2000 |pmid= 11021819 |doi=  }}
*{{cite journal  | author=Bertin J, Guo Y, Wang L, ''et al.'' |title=CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. |journal=J. Biol. Chem. |volume=275 |issue= 52 |pages= 41082-6 |year= 2001 |pmid= 11053425 |doi= 10.1074/jbc.C000726200 }}
*{{cite journal  | author=Uren AG, O'Rourke K, Aravind LA, ''et al.'' |title=Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. |journal=Mol. Cell |volume=6 |issue= 4 |pages= 961-7 |year= 2000 |pmid= 11090634 |doi=  }}
*{{cite journal  | author=Poyet JL, Srinivasula SM, Alnemri ES |title=vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma. |journal=J. Biol. Chem. |volume=276 |issue= 5 |pages= 3183-7 |year= 2001 |pmid= 11113112 |doi= 10.1074/jbc.C000792200 }}
*{{cite journal  | author=Ruland J, Duncan GS, Elia A, ''et al.'' |title=Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. |journal=Cell |volume=104 |issue= 1 |pages= 33-42 |year= 2001 |pmid= 11163238 |doi=  }}
*{{cite journal  | author=Wang L, Guo Y, Huang WJ, ''et al.'' |title=Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21405-9 |year= 2001 |pmid= 11259443 |doi= 10.1074/jbc.M102488200 }}
*{{cite journal  | author=Lucas PC, Yonezumi M, Inohara N, ''et al.'' |title=Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19012-9 |year= 2001 |pmid= 11262391 |doi= 10.1074/jbc.M009984200 }}
*{{cite journal  | author=Bertin J, Wang L, Guo Y, ''et al.'' |title=CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B. |journal=J. Biol. Chem. |volume=276 |issue= 15 |pages= 11877-82 |year= 2001 |pmid= 11278692 |doi= 10.1074/jbc.M010512200 }}
*{{cite journal  | author=Gaide O, Martinon F, Micheau O, ''et al.'' |title=Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. |journal=FEBS Lett. |volume=496 |issue= 2-3 |pages= 121-7 |year= 2001 |pmid= 11356195 |doi=  }}
}}
{{refend}}


{{protein-stub}}
BCL10 has been shown to [[Protein-protein interaction|interact]] with:
{{WikiDoc Sources}}
{{div col|colwidth=20em}}
* [[CARD10]],<ref name = pmid11259443>{{cite journal | vauthors = Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J | title = Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 21405–9 | date = June 2001 | pmid = 11259443 | doi = 10.1074/jbc.M102488200 }}</ref>
* [[CARD11]],<ref name = pmid11278692>{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82 | date = April 2001 | pmid = 11278692 | doi = 10.1074/jbc.M010512200 }}</ref>
* [[CARD14]],<ref name="pmid11278692"/>
* [[CARD9]]<ref name = pmid11053425>{{cite journal | vauthors = Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES | title = CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B | journal = J. Biol. Chem. | volume = 275 | issue = 52 | pages = 41082–6 | date = Dec 2000 | pmid = 11053425 | doi = 10.1074/jbc.C000726200 }}</ref>
* [[CRADD]],<ref name="pmid22323537">{{cite journal | vauthors = Lin Q, Liu Y, Moore DJ, Elizer SK, Veach RA, Hawiger J, Ruley HE | title = Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes | journal = J. Immunol. | volume = 188 | issue = 6 | pages = 2493–7 | year = 2012 | pmid = 22323537 | pmc = 3294148 | doi = 10.4049/jimmunol.1101502 }}</ref>
* [[IKBKG]],<ref name = pmid18287044>{{cite journal | vauthors = Wu CJ, Ashwell JD | title = NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 105 | issue = 8 | pages = 3023–8 | date = February 2008 | pmid = 18287044 | pmc = 2268578 | doi = 10.1073/pnas.0712313105 }}</ref>
* [[MALT1]],<ref name = pmid11090634>{{cite journal | vauthors = Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, Dixit VM | title = Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma | journal = Mol. Cell | volume = 6 | issue = 4 | pages = 961–7 | date = October 2000 | pmid = 11090634 | doi = 10.1016/S1097-2765(05)00086-9 }}</ref>  and
* [[TRAF2]].<ref name = pmid10753917>{{cite journal | vauthors = Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M | title = Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein | journal = J. Biol. Chem. | volume = 275 | issue = 15 | pages = 11114–20 | date = April 2000 | pmid = 10753917 | doi = 10.1074/jbc.275.15.11114 }}</ref>
{{Div col end}}
{{Clear}}
 
== References ==
{{Reflist|35em}}
 
==External links==
* {{UCSC gene info|BCL10}}
 
== Further reading ==
{{Refbegin|35em}}
* {{cite journal | vauthors = Bertoni F, Cavalli F, Cotter FE, Zucca E | title = Genetic alterations underlying the pathogenesis of MALT lymphoma | journal = Hematol. J. | volume = 3 | issue = 1 | pages = 10–3 | year = 2003 | pmid = 11960389 | doi = 10.1038/sj/thj/6200146 }}
* {{cite journal | vauthors = Lee WC, Balsara B, Liu Z, Jhanwar SC, Testa JR | title = Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma | journal = Cancer Res. | volume = 56 | issue = 19 | pages = 4297–301 | year = 1996 | pmid = 8813110 | doi =  }}
* {{cite journal | vauthors = Koseki T, Inohara N, Chen S, Carrio R, Merino J, Hottiger MO, Nabel GJ, Núñez G | title = CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10 | journal = J. Biol. Chem. | volume = 274 | issue = 15 | pages = 9955–9961 | year = 1999 | pmid = 10187770 | doi = 10.1074/jbc.274.15.9955 }}
* {{cite journal | vauthors = Thome M, Martinon F, Hofmann K, Rubio V, Steiner V, Schneider P, Mattmann C, Tschopp J | title = Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase | journal = J. Biol. Chem. | volume = 274 | issue = 15 | pages = 9962–9968 | year = 1999 | pmid = 10187771 | doi = 10.1074/jbc.274.15.9962 }}
* {{cite journal | vauthors = Yan M, Lee J, Schilbach S, Goddard A, Dixit V | title = mE10, a novel caspase recruitment domain-containing proapoptotic molecule | journal = J. Biol. Chem. | volume = 274 | issue = 15 | pages = 10287–10292 | year = 1999 | pmid = 10187815 | doi = 10.1074/jbc.274.15.10287 }}
* {{cite journal | vauthors = Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, Xue L, Rakestraw KM, Naeve CW, Beckmann G, Weisenburger DD, Sanger WG, Nowotny H, Vesely M, Callet-Bauchu E, Salles G, Dixit VM, Rosenthal A, Schlegelberger B, Morris SW | title = Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32) | journal = Nat. Genet. | volume = 22 | issue = 1 | pages = 63–68 | year = 1999 | pmid = 10319863 | doi = 10.1038/8767 }}
* {{cite journal | vauthors = Srinivasula SM, Ahmad M, Lin JH, Poyet JL, Fernandes-Alnemri T, Tsichlis PN, Alnemri ES | title = CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis | journal = J. Biol. Chem. | volume = 274 | issue = 25 | pages = 17946–17954 | year = 1999 | pmid = 10364242 | doi = 10.1074/jbc.274.25.17946 }}
* {{cite journal | vauthors = Apostolou S, De Rienzo A, Murthy SS, Jhanwar SC, Testa JR | title = Absence of BCL10 mutations in human malignant mesothelioma | journal = Cell | volume = 97 | issue = 6 | pages = 684–686 | year = 1999 | pmid = 10380921 | doi = 10.1016/S0092-8674(02)09765-9 }}
* {{cite journal | vauthors = Costanzo A, Guiet C, Vito P | title = c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB | journal = J. Biol. Chem. | volume = 274 | issue = 29 | pages = 20127–20132 | year = 1999 | pmid = 10400625 | doi = 10.1074/jbc.274.29.20127 }}
* {{cite journal | vauthors = Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M | title = Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein | journal = J. Biol. Chem. | volume = 275 | issue = 15 | pages = 11114–11120 | year = 2000 | pmid = 10753917 | doi = 10.1074/jbc.275.15.11114 }}
* {{cite journal | vauthors = Ye H, Dogan A, Karran L, Willis TG, Chen L, Wlodarska I, Dyer MJ, Isaacson PG, Du MQ | title = BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma | journal = Am. J. Pathol. | volume = 157 | issue = 4 | pages = 1147–1154 | year = 2000 | pmid = 11021819 | pmc = 1850175 | doi = 10.1016/S0002-9440(10)64630-5 }}
* {{cite journal | vauthors = Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES | title = CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B | journal = J. Biol. Chem. | volume = 275 | issue = 52 | pages = 41082–41086 | year = 2001 | pmid = 11053425 | doi = 10.1074/jbc.C000726200 }}
* {{cite journal | vauthors = Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, Dixit VM | title = Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma | journal = Mol. Cell | volume = 6 | issue = 4 | pages = 961–967 | year = 2000 | pmid = 11090634 | doi = 10.1016/S1097-2765(05)00086-9 }}
* {{cite journal | vauthors = Poyet JL, Srinivasula SM, Alnemri ES | title = vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma | journal = J. Biol. Chem. | volume = 276 | issue = 5 | pages = 3183–3187 | year = 2001 | pmid = 11113112 | doi = 10.1074/jbc.C000792200 }}
* {{cite journal | vauthors = Ruland J, Duncan GS, Elia A, del Barco Barrantes I, Nguyen L, Plyte S, Millar DG, Bouchard D, Wakeham A, Ohashi PS, Mak TW | title = Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure | journal = Cell | volume = 104 | issue = 1 | pages = 33–42 | year = 2001 | pmid = 11163238 | doi = 10.1016/S0092-8674(01)00189-1 }}
* {{cite journal | vauthors = Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J | title = Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 21405–21409 | year = 2001 | pmid = 11259443 | doi = 10.1074/jbc.M102488200 }}
* {{cite journal | vauthors = Lucas PC, Yonezumi M, Inohara N, McAllister-Lucas LM, Abazeed ME, Chen FF, Yamaoka S, Seto M, Nunez G | title = Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19012–19019 | year = 2001 | pmid = 11262391 | doi = 10.1074/jbc.M009984200 }}
* {{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–11882 | year = 2001 | pmid = 11278692 | doi = 10.1074/jbc.M010512200 }}
* {{cite journal | vauthors = Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J | title = Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation | journal = FEBS Lett. | volume = 496 | issue = 2–3 | pages = 121–127 | year = 2001 | pmid = 11356195 | doi = 10.1016/S0014-5793(01)02414-0 }}
{{Refend}}
 
[[Category:Proteins]]
[[Category:Tumor_suppressor_genes]]

Revision as of 17:54, 5 December 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene.[1][2] Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL9, it has clinical significance in lymphoma.

Function

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with the paracaspase MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.[2] Bcl10 has been shown to be functionally conserved all the way back to zebrafish. [3]

Interactions

BCL10 has been shown to interact with:

References

  1. ↑ Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson PG, Dyer MJ (March 1999). "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types". Cell. 96 (1): 35–45. doi:10.1016/S0092-8674(00)80957-5. PMID 9989495.
  2. ↑ 2.0 2.1 "Entrez Gene: BCL10 B-cell CLL/lymphoma 10".
  3. ↑ Mazzone P, Scudiero I, Ferravante A, Paolucci M, D'Andrea LE, Varricchio E, Telesio G, De Maio C, Pizzulo M, Zotti T, Reale C, Vito P, Stilo R (April 2015). "Functional characterization of zebrafish. (Danio rerio) Bcl10". PLOS ONE. 10 (4): e0122365. doi:10.1371/journal.pone.0122365. PMC 4388727. PMID 25849213.
  4. ↑ Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
  5. ↑ 5.0 5.1 Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (April 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692.
  6. ↑ Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES (Dec 2000). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. Chem. 275 (52): 41082–6. doi:10.1074/jbc.C000726200. PMID 11053425.
  7. ↑ Lin Q, Liu Y, Moore DJ, Elizer SK, Veach RA, Hawiger J, Ruley HE (2012). "Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes". J. Immunol. 188 (6): 2493–7. doi:10.4049/jimmunol.1101502. PMC 3294148. PMID 22323537.
  8. ↑ Wu CJ, Ashwell JD (February 2008). "NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. 105 (8): 3023–8. doi:10.1073/pnas.0712313105. PMC 2268578. PMID 18287044.
  9. ↑ Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, Dixit VM (October 2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell. 6 (4): 961–7. doi:10.1016/S1097-2765(05)00086-9. PMID 11090634.
  10. ↑ Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. PMID 10753917.

External links

Further reading

  • Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). "Genetic alterations underlying the pathogenesis of MALT lymphoma". Hematol. J. 3 (1): 10–3. doi:10.1038/sj/thj/6200146. PMID 11960389.
  • Lee WC, Balsara B, Liu Z, Jhanwar SC, Testa JR (1996). "Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma". Cancer Res. 56 (19): 4297–301. PMID 8813110.
  • Koseki T, Inohara N, Chen S, Carrio R, Merino J, Hottiger MO, Nabel GJ, Núñez G (1999). "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10". J. Biol. Chem. 274 (15): 9955–9961. doi:10.1074/jbc.274.15.9955. PMID 10187770.
  • Thome M, Martinon F, Hofmann K, Rubio V, Steiner V, Schneider P, Mattmann C, Tschopp J (1999). "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase". J. Biol. Chem. 274 (15): 9962–9968. doi:10.1074/jbc.274.15.9962. PMID 10187771.
  • Yan M, Lee J, Schilbach S, Goddard A, Dixit V (1999). "mE10, a novel caspase recruitment domain-containing proapoptotic molecule". J. Biol. Chem. 274 (15): 10287–10292. doi:10.1074/jbc.274.15.10287. PMID 10187815.
  • Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, Xue L, Rakestraw KM, Naeve CW, Beckmann G, Weisenburger DD, Sanger WG, Nowotny H, Vesely M, Callet-Bauchu E, Salles G, Dixit VM, Rosenthal A, Schlegelberger B, Morris SW (1999). "Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)". Nat. Genet. 22 (1): 63–68. doi:10.1038/8767. PMID 10319863.
  • Srinivasula SM, Ahmad M, Lin JH, Poyet JL, Fernandes-Alnemri T, Tsichlis PN, Alnemri ES (1999). "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis". J. Biol. Chem. 274 (25): 17946–17954. doi:10.1074/jbc.274.25.17946. PMID 10364242.
  • Apostolou S, De Rienzo A, Murthy SS, Jhanwar SC, Testa JR (1999). "Absence of BCL10 mutations in human malignant mesothelioma". Cell. 97 (6): 684–686. doi:10.1016/S0092-8674(02)09765-9. PMID 10380921.
  • Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB". J. Biol. Chem. 274 (29): 20127–20132. doi:10.1074/jbc.274.29.20127. PMID 10400625.
  • Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–11120. doi:10.1074/jbc.275.15.11114. PMID 10753917.
  • Ye H, Dogan A, Karran L, Willis TG, Chen L, Wlodarska I, Dyer MJ, Isaacson PG, Du MQ (2000). "BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma". Am. J. Pathol. 157 (4): 1147–1154. doi:10.1016/S0002-9440(10)64630-5. PMC 1850175. PMID 11021819.
  • Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES (2001). "CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. Chem. 275 (52): 41082–41086. doi:10.1074/jbc.C000726200. PMID 11053425.
  • Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, Dixit VM (2000). "Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma". Mol. Cell. 6 (4): 961–967. doi:10.1016/S1097-2765(05)00086-9. PMID 11090634.
  • Poyet JL, Srinivasula SM, Alnemri ES (2001). "vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma". J. Biol. Chem. 276 (5): 3183–3187. doi:10.1074/jbc.C000792200. PMID 11113112.
  • Ruland J, Duncan GS, Elia A, del Barco Barrantes I, Nguyen L, Plyte S, Millar DG, Bouchard D, Wakeham A, Ohashi PS, Mak TW (2001). "Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure". Cell. 104 (1): 33–42. doi:10.1016/S0092-8674(01)00189-1. PMID 11163238.
  • Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–21409. doi:10.1074/jbc.M102488200. PMID 11259443.
  • Lucas PC, Yonezumi M, Inohara N, McAllister-Lucas LM, Abazeed ME, Chen FF, Yamaoka S, Seto M, Nunez G (2001). "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway". J. Biol. Chem. 276 (22): 19012–19019. doi:10.1074/jbc.M009984200. PMID 11262391.
  • Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–11882. doi:10.1074/jbc.M010512200. PMID 11278692.
  • Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–127. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195.
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