View source for Avoiding Cardiovascular Events Through Combination Therapy In Patients Living With Systolic Hypertension

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== Complete Title of Study ==
A Prospective, Multinational, Multicenter Trial to Compare the Effects of Amlodipine/Benazepril to Benazepril and Hydrochlorothiazide Combined on the Reduction of Cardiovascular Morbidity and Mortality in Patients With High Risk Hypertension

==Study Acronym <small>(The trial's abbreviation if there is one) </small>==
ACCOMPLISH

==Principal Investigator, Co-investigators, and Collaborating Institutions==
'''Study Chair:''' Novartis Pharmaceuticals

==Overview of Trial==
The goal of the ACCOMPLISH trial was to compare the effectiveness of two combination drugs (amlodipine/benazepril and benazepril/HCTZ) on reducing heart disease and death in 11,464 high risk hypertensive patients.

==Disease State(s) Studied <small>(e.g. acute MI, breast cancer, etc.)</small>==
*Hypertension

==Study Phase <small>(e.g. Phase I,II,III,IV) [[Study phase|Study Phases are defined here]]</small>==
Phase III

==Study Design <small>(e.g. multicenter, randomized, double blind, placebo controlled)</small>==
Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Safety/Efficacy Study

== Study Arms and How They Were Treated (Intervention) <small>[[Study arms|(Explanation here)]]</small>==
None reported

== Primary Pre-Specified Endpoint ==
* Time to having a cardiovascular or neurologic event, including: death from a cardiovascular event, heart attack,
* stroke, hospitalization for chest pain or heart failure, or
* procedure to open a blockage in an arterial blood vessel

== Secondary Endpoints ==
* Time to having a cardiovascular or neurologic event, including: death from a cardiovascular event, heart attack,
* stroke, or hospitalization for heart failure or or
* procedure to open a blockage in an arterial blood vessel
* Risk of developing diabetes
* Progression of kidney disease

== Inclusion Criteria ==
* At least 55 years of age.
* Have elevated blood pressure and at least one other cardiovascular disease or diabetes or evidence of damage to the kidneys, brain, blood vessels or heart as defined in the protocol

==Exclusion Criteria==
*Allergy to any of the drugs administered in this trial. Selected laboratory tests
*Other protocol-defined exclusion criteria may apply.

==Outcome: Primary endpoint <small>(Report both relative risk reduction and absolute risk reduction as well as number needed to treat if available)</small>==
None reported

==Outcome: Secondary endpoint <small>(Report both relative risk reduction and absolute risk reduction as well as number needed to treat if available)</small>==
None reported

==Outcome: Exploratory endpoints <small>(Report both relative risk reduction and absolute risk reduction as well as number needed to treat if available)</small>==
None reported

==Outcome: Safety endpoints <small>(Report both relative risk and absolute risk as well as number needed to harm if available)</small>==
None reported

==Conclusions of the Investigators <small>(Quote the investigators conclusions here)</small>==
None reported

==Commentary, Discussion and Limitations of the Trial<small> (Anyone can add comments)</small>==
None reported

==Slides==
None reported

==Video Commentary==
None reported

== References [[Help:Adding_References_to_Articles|(How to insert a reference)]]==
{{cite journal |author=Jamerson K, Weber MA, Bakris GL, ''et al.'' |title=Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients |journal=N. Engl. J. Med. |volume=359 |issue=23 |pages=2417–28 |year=2008 |month=December |pmid=19052124 |doi=10.1056/NEJMoa0806182 |url=}}

==External sites for further information <small>[[Help:Links|(How to insert links)]]</small>==
None reported

==Detailed information about the trial==
==Ages==
55 years and older

==Gender <small>(Indicate whether men, women or both were enrolled)</small>==
Both

==Accepts Healthy Volunteers <small>(Answer yes or no)</small>==
None reported

==Enrollment Period <small>(Study start and end date)</small>==
'''Study start date:''' October 2003

==Recruitment Status [[Recruitment status|(explanation)]]==
Completed

==Enrollment <small>(Total number of patients enrolled)</small>==
11,464

==Study Sponsor <small>(e.g. Investigator initiated or company name)</small>==
Novartis Pharmaceuticals

==Source of Data <small>(Where is this data on this page coming from: publication, principal investigator, or co-investigator)</small>==
Novartis


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[[Category:Clinical trials]]

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