View source for Apoptosis-antagonizing transcription factor

{{Infobox_gene}}
'''Protein AATF''' is a [[protein]] that in humans is encoded by the ''AATF'' [[gene]].<ref name="pmid11027528">{{cite journal | vauthors = Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Mäki M, Kainulainen H | title = Identification of novel transcription factor-like gene from human intestinal cells | journal = Biochemical and Biophysical Research Communications | volume = 276 | issue = 2 | pages = 660–6 | date = Sep 2000 | pmid = 11027528 | pmc =  | doi = 10.1006/bbrc.2000.3480 }}</ref><ref name="pmid10783144">{{cite journal | vauthors = Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C | title = Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb | journal = FASEB Journal | volume = 14 | issue = 7 | pages = 904–12 | date = May 2000 | pmid = 10783144 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AATF apoptosis antagonizing transcription factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26574| accessdate = }}</ref>

== Function ==

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.<ref name="entrez"/>

== Interactions ==

Apoptosis-antagonizing transcription factor has been shown to [[Protein-protein interaction|interact]] with:
* [[PAWR]],<ref name = pmid14627703>{{cite journal | vauthors = Guo Q, Xie J | title = AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4596–603 | date = Feb 2004 | pmid = 14627703 | doi = 10.1074/jbc.M309811200 }}</ref> 
* [[POLR2J]],<ref name = pmid10783144/>
* [[Retinoblastoma protein]],<ref name = pmid10783144/><ref name = pmid12450794>{{cite journal | vauthors = Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M | title = Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb | journal = Cancer Cell | volume = 2 | issue = 5 | pages = 387–99 | date = Nov 2002 | pmid = 12450794 | doi =  10.1016/s1535-6108(02)00182-4| author14 = Fanciulli Maurizio | author13 = Passananti Claudio }}</ref> and
* [[Sp1 transcription factor]].<ref name = pmid12847090>{{cite journal | vauthors = Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M | title = Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36496–504 | date = Sep 2003 | pmid = 12847090 | doi = 10.1074/jbc.M306694200 }}</ref> 

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Page G, Lödige I, Kögel D, Scheidtmann KH | title = AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis | journal = FEBS Letters | volume = 462 | issue = 1-2 | pages = 187–91 | date = Nov 1999 | pmid = 10580117 | doi = 10.1016/S0014-5793(99)01529-X }}
* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
* {{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4100–9 | date = Nov 2002 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}
* {{cite journal | vauthors = Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M | title = Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb | journal = Cancer Cell | volume = 2 | issue = 5 | pages = 387–99 | date = Nov 2002 | pmid = 12450794 | doi = 10.1016/S1535-6108(02)00182-4 }}
* {{cite journal | vauthors = Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M | title = Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36496–504 | date = Sep 2003 | pmid = 12847090 | doi = 10.1074/jbc.M306694200 }}
* {{cite journal | vauthors = Guo Q, Xie J | title = AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4596–603 | date = Feb 2004 | pmid = 14627703 | doi = 10.1074/jbc.M309811200 }}
* {{cite journal | vauthors = Barbato C, Corbi N, Canu N, Fanciulli M, Serafino A, Ciotti M, Libri V, Bruno T, Amadoro G, De Angelis R, Calissano P, Passananti C | title = Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis | journal = Molecular and Cellular Neurosciences | volume = 24 | issue = 4 | pages = 1038–50 | date = Dec 2003 | pmid = 14697667 | doi = 10.1016/j.mcn.2003.08.002 }}
* {{cite journal | vauthors = Burgdorf S, Leister P, Scheidtmann KH | title = TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination | journal = The Journal of Biological Chemistry | volume = 279 | issue = 17 | pages = 17524–34 | date = Apr 2004 | pmid = 14761944 | doi = 10.1074/jbc.M313703200 }}
* {{cite journal | vauthors = Xie J, Guo Q | title = AATF protects neural cells against oxidative damage induced by amyloid beta-peptide | journal = Neurobiology of Disease | volume = 16 | issue = 1 | pages = 150–7 | date = Jun 2004 | pmid = 15207272 | doi = 10.1016/j.nbd.2004.02.003 }}
* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = Jan 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = Apr 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
* {{cite journal | vauthors = Kaul D, Mehrotra A | title = Functional characterization of AATF transcriptome in human leukemic cells | journal = Molecular and Cellular Biochemistry | volume = 297 | issue = 1-2 | pages = 215–20 | date = Mar 2007 | pmid = 17006618 | doi = 10.1007/s11010-006-9317-1 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
{{refend}}

== External links ==
*{{MeshName|AATF+protein,+human}}
* {{UCSC genome browser|AATF}}  
* {{UCSC gene details|AATF}}

{{NLM content}}
{{Transcription factors|g1}}


[[Category:Transcription factors]]

{{gene-17-stub}}