Aplastic anemia pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
=== Physiology === | |||
The normal physiology of bone marrow can be understood as follows:<ref name="pmid2406826">{{cite journal |vauthors=Hays K |title=Physiology of normal bone marrow |journal=Semin Oncol Nurs |volume=6 |issue=1 |pages=3–8 |date=February 1990 |pmid=2406826 |doi= |url=}}</ref> | |||
* '''Bone marrow''' is a spongy tissue, found within the spongy or cancellous portions of bones | |||
* It is higly vascularized and richly innervated | |||
* Bone marrow is the primary site of hematopoiesis | |||
* It is composed of hematopoietic cells, marrow adipose tissue, and stromal cells. | |||
* The hematopoiesis is controlled by a various regulatory mechanisms, including growth factors. | |||
* The normal bone marrow structure can be damaged or displaced by aplastic anemia, malignancies or infections. | |||
* This leads to decrease production of blood cells and blood platelets. | |||
. | |||
=== Pathogenesis === | |||
* The exact pathogenesis of [disease name] is not completely understood. | |||
OR | |||
* It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3]. | |||
* [Pathogen name] is usually transmitted via the [transmission route] route to the human host. | |||
* Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell. | |||
* [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells]. | |||
* The progression to [disease name] usually involves the [molecular pathway]. | |||
* The pathophysiology of [disease/malignancy] depends on the histological subtype. | |||
== Genetics == | |||
[Disease name] is transmitted in [mode of genetic transmission] pattern. | |||
OR | |||
Genes involved in the pathogenesis of [disease name] include: | |||
* [Gene1] | |||
* [Gene2] | |||
* [Gene3] | |||
OR | |||
The development of [disease name] is the result of multiple genetic mutations such as: | |||
* [Mutation 1] | |||
* [Mutation 2] | |||
* [Mutation 3] | |||
== Associated Conditions == | |||
== Gross Pathology == | |||
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name]. | |||
== Microscopic Pathology == | |||
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name] | |||
{| align="right" | |||
|[[File:Aplasticanemia.jpg |400px|thumb|right|Image yellow fat ladden marrow https://www.wikidoc.org/index.php/File:Aplasticanemia.jpg source:By Wmheric [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)] [Public domain], from Wikimedia Commons]]] | |||
|} | |||
==References== | ==References== | ||
Revision as of 15:02, 15 August 2018
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Aplastic anemia Microchapters |
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Case Studies |
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Aplastic anemia pathophysiology On the Web |
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American Roentgen Ray Society Images of Aplastic anemia pathophysiology |
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Risk calculators and risk factors for Aplastic anemia pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.
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Overview
Pathophysiology
Physiology
The normal physiology of bone marrow can be understood as follows:[1]
- Bone marrow is a spongy tissue, found within the spongy or cancellous portions of bones
- It is higly vascularized and richly innervated
- Bone marrow is the primary site of hematopoiesis
- It is composed of hematopoietic cells, marrow adipose tissue, and stromal cells.
- The hematopoiesis is controlled by a various regulatory mechanisms, including growth factors.
- The normal bone marrow structure can be damaged or displaced by aplastic anemia, malignancies or infections.
- This leads to decrease production of blood cells and blood platelets.
.
Pathogenesis
- The exact pathogenesis of [disease name] is not completely understood.
OR
- It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
- [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
- Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
- [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
- The progression to [disease name] usually involves the [molecular pathway].
- The pathophysiology of [disease/malignancy] depends on the histological subtype.
Genetics
[Disease name] is transmitted in [mode of genetic transmission] pattern.
OR
Genes involved in the pathogenesis of [disease name] include:
- [Gene1]
- [Gene2]
- [Gene3]
OR
The development of [disease name] is the result of multiple genetic mutations such as:
- [Mutation 1]
- [Mutation 2]
- [Mutation 3]
Associated Conditions
Gross Pathology
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name]
 |
