Aplastic anemia laboratory findings: Difference between revisions
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{{Aplastic anemia}} | {{Aplastic anemia}} | ||
{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com] {{N.F}} | {{CMG}} {{shyam}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh13579@gmail.com] {{N.F}} | ||
==Overview== | ==Overview== | ||
Patients with [[aplastic anemia]] have a hypoplastic bone marrow (<20% cellularity), [[pancytopenia]] | Patients with [[aplastic anemia]] have a hypoplastic bone marrow (<20% cellularity), [[pancytopenia]], transfusion-dependent anemia, [[thrombocytopenia]], severe [[neutropenia]]), low [[reticulocyte count]], and normal maturation of all cell lines. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of aplastic anemia include:<ref>{{cite journal|doi=10.1111/j.1365}}</ref> | Laboratory findings consistent with the diagnosis of aplastic anemia include:<ref>{{cite journal|doi=10.1111/j.1365}}</ref> | ||
===Complete | ===Complete blood count (CBC)=== | ||
* Decreased [[hemoglobin]] | * Decreased [[hemoglobin]] | ||
* Decreased [[hematocrit]] | * Decreased [[hematocrit]] | ||
* [[ | * Decreased [[white blood cell]] count | ||
* Decreased [[platelet count]] | |||
===Reticulocyte | |||
* [[ | ===Reticulocyte count=== | ||
* Decreased reticulocyte count ([[reticulocytopenia]]) | |||
=== Peripheral blood smear === | === Peripheral blood smear === | ||
* [[Macrocytosis]] | * [[Macrocytosis]] | ||
* [[Poikilocytosis]] | * [[Poikilocytosis]] | ||
* Small | * Small-sized [[platelet|platelets]] | ||
===Other tests=== | ===Other tests=== | ||
| Line 29: | Line 31: | ||
* [[Thyroid]] function tests | * [[Thyroid]] function tests | ||
* Viral studies | * Viral studies | ||
* [[Vitamin B12]] and [[folic acid]] levels | * [[Vitamin B12]] and [[folic acid]] levels | ||
==Definitive Diagnosis== | ==Definitive Diagnosis== | ||
===Bone | ===Bone marrow aspiration and biopsy=== | ||
* Hypocellular bone marrow with increased [[adipose tissue]] and decreased [[ | * Hypocellular bone marrow with increased [[adipose tissue]] and decreased [[hematopoietic cell|hematopoietic cells]] in the marrow space | ||
* | * Normal maturation of all [[cell]] lines. | ||
==References== | ==References== | ||
Revision as of 02:33, 3 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [3] Nazia Fuad M.D.
Overview
Patients with aplastic anemia have a hypoplastic bone marrow (<20% cellularity), pancytopenia, transfusion-dependent anemia, thrombocytopenia, severe neutropenia), low reticulocyte count, and normal maturation of all cell lines.
Laboratory Findings
Laboratory findings consistent with the diagnosis of aplastic anemia include:[1]
Complete blood count (CBC)
- Decreased hemoglobin
- Decreased hematocrit
- Decreased white blood cell count
- Decreased platelet count
Reticulocyte count
- Decreased reticulocyte count (reticulocytopenia)
Peripheral blood smear
- Macrocytosis
- Poikilocytosis
- Small-sized platelets
Other tests
The following tests should be performed to rule out other conditions:
- Renal function
- Basic metabolic panel
- Liver enzymes
- Thyroid function tests
- Viral studies
- Vitamin B12 and folic acid levels
Definitive Diagnosis
Bone marrow aspiration and biopsy
- Hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space
- Normal maturation of all cell lines.
References
- ↑ . doi:10.1111/j.1365. Missing or empty
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