Aplastic anemia history and symptoms

Jump to navigation Jump to search

Aplastic anemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Aplastic anemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Aplastic anemia history and symptoms On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Aplastic anemia history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Aplastic anemia history and symptoms

CDC on Aplastic anemia history and symptoms

Aplastic anemia history and symptoms in the news

Blogs on Aplastic anemia history and symptoms

Directions to Hospitals Treating Aplastic anemia

Risk calculators and risk factors for Aplastic anemia history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [2] Nazia Fuad M.D.

Overview

Aplastic anemia is seen as a result of hypoplastic bone marrow causing pancytopenia (anemia, neutropenia, thrombocytopenia). The history and symptoms seen are secondary to these abnormalities.

History

The hallmark of aplastic anemia is past history of anemia (shortness of breath, dizziness, headaches, or other signs and symptoms of anemia), exposure to certain toxins or medicines, radiation or chemotherapy, infections or signs of infections, such as fever, bruises or tendency to bleed easily. Family history of anemia or other blood disorders should also be sought.

Symptoms

Decrease numbers of red blood cells, white blood cells, and platelets cause most of the signs and symptoms of aplastic anemia.[1]

Red Blood Cells

White Blood Cells

  • Fever
  • Frequent infections
  • Flu-like illnesses

Platelets

Other Symptoms

Aplastic anemia can cause signs and symptoms that aren't directly related to low blood cell counts. Examples include

Paroxysmal Nocturnal Hemoglobinuria

If symptoms do occur, they may include:

In people who have aplastic anemia and PNH, either condition can develop first.

Diagnosis and management of aplastic anemia [2] (DONOT EDIT)

Diagnosis and Evaluation of aplastic anemia

  • Careful history and clinical examination
  • Detailed drug and occupational exposure history
  • Patients presenting with aplastic anaemia should be assessed to:
  • Multidisciplinary approach
  • Referral to specialist if necessary

References

  1. Shallis RM, Ahmad R, Zeidan AM (July 2018). "Aplastic anemia: etiology, molecular pathogenesis and emerging concepts". Eur. J. Haematol. doi:10.1111/ejh.13153. PMID 30055055.
  2. Marsh JC, Ball SE, Cavenagh J, Darbyshire P, Dokal I, Gordon-Smith EC; et al. (2009). "Guidelines for the diagnosis and management of aplastic anaemia". Br J Haematol. 147 (1): 43–70. doi:10.1111/j.1365-2141.2009.07842.x. PMID 19673883.