Aplastic anemia diagnostic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Nazia Fuad M.D.

Overview

The bone marrow biopsy is the gold standard test for the diagnosis of aplastic anemia. A hematopathologist will review the bone marrow biopsy findings, and confirmatory results for aplastic anemia include hypoplasia with <20% cellularity, normal maturation of all cell lines, presence of fat cells and stroma in bone marrow space. Residual hematopoietic cells are morphologically normal. Hematopoiesis is not megaloblastic.

Diagnostic Study of Choice

Study of choice

The bone marrow biopsy is the gold standard test for the diagnosis of aplastic anemia[1]

Diagnostic results

The following findings on performing bone marrow biopsy are confirmatory for aplastic anemia:

Sequence of diagnostic studies

References

  1. Dezern AE, Brodsky RA (April 2011). "Clinical management of aplastic anemia". Expert Rev Hematol. 4 (2): 221–30. doi:10.1586/ehm.11.11. PMC 3138728. PMID 21495931.
  2. D'Andrea AD, Grompe M (January 2003). "The Fanconi anaemia/BRCA pathway". Nat. Rev. Cancer. 3 (1): 23–34. doi:10.1038/nrc970. PMID 12509764.

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